Goodpasture Syndrome Questions & Answers

Updated: Dec 16, 2018
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

When was Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM) first identified?

What is the pathophysiology of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of base membranes in the pathophysiology of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of the alveolar endothelium in the pathogenesis of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of genetics to the pathophysiology of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What causes Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the prevalence of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Which patient groups have the highest prevalence of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the prognosis of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Presentation

Which clinical history findings are characteristic of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What are the signs and symptoms of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Which physical findings are characteristic of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

DDX

Which conditions are included in the differential diagnoses of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What are the differential diagnoses for Goodpasture Syndrome?

Workup

How is Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM) diagnosed?

What is the role of urinalysis and blood studies in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of anti–GBM antibody testing in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of ANCA antibody testing in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of chest radiograph in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of pulmonary function testing in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of biopsy in the workup of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Treatment

How is Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM) treated?

What is the role of plasmapheresis in the treatment of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of immunosuppressive therapy in the treatment of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What are the risk factors for relapse of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

What is the role of renal transplantation in the treatment of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Which specialist consultations are beneficial to patients with Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Medications

What is the role of drug treatment for Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Which medications in the drug class Antibiotics are used in the treatment of Goodpasture Syndrome?

Which medications in the drug class Alkylating Agents (Cytotoxic Agents) are used in the treatment of Goodpasture Syndrome?

Which medications in the drug class Immunosuppressive agents are used in the treatment of Goodpasture Syndrome?