Hyperchloremic Acidosis Differential Diagnoses

Updated: Jan 04, 2023
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Diagnostic Considerations

Conditions to consider in the differential diagnosis of hyperchloremic acidosis are as follows:

  • Nonanion gap metabolic acidosis

  • Renal tubular acidosis

  • Vitamin D deficiency

  • Chronic hypocalcemia

  • Vitamin D resistance

  • Secondary hyperparathyroidism

  • Monoclonal gammopathy and myeloma

  • Lowe syndrome

  • Metachromatic leukodystrophy

  • Methylmalonic acidemia

  • Sickle cell disease

  • Obstructive uropathy

  • Fabry disease

  • Chronic diarrhea or other extrarenal loss of bicarbonate

Differential Diagnoses