Hyperphosphatemia Differential Diagnoses

Updated: Oct 23, 2023
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Diagnostic Considerations

Pseudohyperphosphatemia is most commonly due to paraproteinemia from the following:

  • Waldenström macroglobulinemia
  • Multiple myeloma
  • Monoclonal gammopathy of unknown significance

Other differentials to be considered include the following:

  • Vitamin D intoxication
  • Oral saline laxative (Phospho-soda) abuse
  • Pseudohyperphosphatemia
  • Pseudohypoparathyroidism
  • Rhabdomyolysis

Differential Diagnoses