Hyperphosphatemia Questions & Answers

Updated: Dec 02, 2020
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Questions & Answers

Overview

What causes hyperphosphatemia?

What are the signs and symptoms of hyperphosphatemia?

What are the signs and symptoms of acute hyperphosphatemia?

What is the role of a full chemistry profile in the evaluation of hyperphosphatemia?

What may cause hyperphosphatemia if renal function is normal?

What is the role of urinary phosphate measurement in the evaluation of hyperphosphatemia?

How is hyperphosphatemia treated?

What is the clinical background of hyperphosphatemia?

What is the role of phosphate in hyperphosphatemia?

What is the role of intracellular phosphate in hyperphosphatemia?

What is the role of type 1 sodium-phosphate transporters in hyperphosphatemia?

Where are type 2 sodium-phosphate transporters expressed in hyperphosphatemia?

Where are type 2a sodium-phosphate transporters expressed in hyperphosphatemia?

Where are type 2b sodium-phosphate transporters expressed in hyperphosphatemia?

Where are type 2c sodium-phosphate transporters expressed in hyperphosphatemia?

What is the role of type 3 sodium-phosphate transporters in hyperphosphatemia?

Which factors affect serum phosphate concentration in hyperphosphatemia?

What is phosphate homeostasis?

What is the role of parathyroid hormone (PTH) and vitamin D in hyperphosphatemia?

What is the role of genetics in hyperphosphatemia?

What is the role of fibroblast growth factor 23 (FGF23) in hyperphosphatemia?

What is the role of stanniocalcins (STC1 and STC2) in hyperphosphatemia?

What is the role of hypoparathyroidism in the pathophysiology of hyperphosphatemia?

What are the pathogenic mechanisms in hyperphosphatemia?

What is the role of excessive phosphate intake in the pathogenesis of hyperphosphatemia?

What is the role of renal failure in the pathogenesis of hyperphosphatemia?

What is the role of tumoral calcinosis in the pathophysiology of hyperphosphatemia?

What is the role of vitamin D intoxication in the pathophysiology of hyperphosphatemia?

What causes a shift from intracellular to extracellular space in the pathogenesis of hyperphosphatemia?

How does hyperphosphatemia cause hypocalcemia?

Hyperphosphatemia increases the risk for which disorders?

What are the cardiovascular effects of hyperphosphatemia?

What are the osseocartilaginous effects of hyperphosphatemia?

How does hyperphosphatemia cause soft-tissue calcification?

What is the role of vascular calcification in the pathophysiology of hyperphosphatemia?

What causes hyperphosphatemia?

What causes an increased intake pathogenesis of hyperphosphatemia?

What causes a decreased excretion pathogenesis of hyperphosphatemia?

What causes the shift of phosphate from intracellular to extracellular space in hyperphosphatemia?

What causes false-positive indication of hyperphosphatemia?

What is the prevalence of hyperphosphatemia in the US?

What is the global prevalence of hyperphosphatemia?

What are the racial predilections of hyperphosphatemia?

How does the prevalence of hyperphosphatemia vary by sex?

How does the prevalence of hyperphosphatemia vary by age?

What is the prognosis of hyperphosphatemia?

What is the prognosis of hyperphosphatemia in renal disease?

What is included in patient education for hyperphosphatemia?

Presentation

What should be the focus of medication history in the evaluation for hyperphosphatemia?

What are the signs and symptoms of hyperphosphatemia?

What should be the focus of history in the evaluation of hyperphosphatemia?

What are the physical findings characteristic of hyperphosphatemia?

DDX

What should be included in the differential diagnoses for hyperphosphatemia?

What are the differential diagnoses for Hyperphosphatemia?

Workup

Which studies should be performed in the evaluation of hyperphosphatemia?

What is the role of a full chemistry profile in the workup of hyperphosphatemia?

What is the role of urinalysis in the evaluation of hyperphosphatemia?

What is the role of imaging studies in the workup of hyperphosphatemia?

Treatment

What is the focus of treatment for hyperphosphatemia?

How is hyperphosphatemia managed in patients on dialysis?

What is the role of surgery in the treatment of hyperphosphatemia?

Which specialist consultations may be beneficial in the treatment of hyperphosphatemia?

How are patients with hyperphosphatemia monitored?

What is the role of tenapanor in the treatment of hyperphosphatemia?

What is the role of phosphate binders in the treatment of hyperphosphatemia?

What is the role of aluminum-containing binders in the treatment of hyperphosphatemia?

What is the role of calcium-containing binders in the treatment of hyperphosphatemia?

Which phosphate binders are used in the treatment of hyperphosphatemia?

What is the role of sucroferric oxyhydroxide (Velphoro) in the treatment of hyperphosphatemia?

What is the role of sevelamer for the treatment of hyperphosphatemia?

What is the role of lanthanum in the treatment of hyperphosphatemia?

What is the role of ferric citrate in the treatment of hyperphosphatemia?

What are the benefits of non-calcium phosphate binders for treatment of hyperphosphatemia?

How is hyperphosphatemia managed in patients with normal renal function?

How is secondary hyperparathyroidism managed in hyperphosphatemia?

How is hypoparathyroidism managed in hyperphosphatemia?

Medications

What is the role of drug treatment for hyperphosphatemia?

Which medications in the drug class Phosphate Binders are used in the treatment of Hyperphosphatemia?

Which medications in the drug class Diuretics are used in the treatment of Hyperphosphatemia?