Metabolic Alkalosis Questions & Answers

1. Brinkman JE, Sharma S. Physiology, Metabolic Alkalosis. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Gillion V, Jadoul M, Devuyst O, Pochet JM. The patient with metabolic alkalosis. Acta Clin Belg. 2018 Oct 27. 1-7. [QxMD MEDLINE Link].

3. Emmett M. Metabolic Alkalosis: A Brief Pathophysiologic Review. Clin J Am Soc Nephrol. 2020 Dec 7. 15 (12):1848-1856. [QxMD MEDLINE Link].

4. Mehler PS, Walsh K. Electrolyte and acid-base abnormalities associated with purging behaviors. Int J Eat Disord. 2016 Mar. 49 (3):311-8. [QxMD MEDLINE Link].

5. Vaidya A, Mulatero P, Baudrand R, Adler GK. The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment. Endocr Rev. 2018 Aug 15. [QxMD MEDLINE Link].

6. Gollasch B, Anistan YM, Canaan-Kühl S, Gollasch M. Late-onset Bartter syndrome type II. Clin Kidney J. 2017 Oct. 10 (5):594-599. [QxMD MEDLINE Link]. [Full Text].

7. Patel AM, Adeseun GA, Goldfarb S. Calcium-alkali syndrome in the modern era. Nutrients. 2013 Nov 27. 5 (12):4880-93. [QxMD MEDLINE Link]. [Full Text].

8. Tentori F, Karaboyas A, Robinson BM, Morgenstern H, Zhang J, Sen A, et al. Association of dialysate bicarbonate concentration with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2013 Oct. 62(4):738-46. [QxMD MEDLINE Link]. [Full Text].

9. Alfano G, Fontana F, Mori G, et al. Acid base disorders in patients with COVID-19. Int Urol Nephrol. 2022 Feb. 54 (2):405-410. [QxMD MEDLINE Link]. [Full Text].

10. Chiumello D, Pozzi T, Fratti I, Modafferi L, Montante M, Papa GFS, et al. Acid-Base Disorders in COVID-19 Patients with Acute Respiratory Distress Syndrome. J Clin Med. 2022 Apr 8. 11 (8):[QxMD MEDLINE Link]. [Full Text].

11. Gennari FJ, Weise WJ. Acid-base disturbances in gastrointestinal disease. Clin J Am Soc Nephrol. 2008 Nov. 3(6):1861-8. [QxMD MEDLINE Link].

12. Weise WJ, Serrano FA, Fought J, Gennari FJ. Acute electrolyte and acid-base disorders in patients with ileostomies: a case series. Am J Kidney Dis. 2008 Sep. 52(3):494-500. [QxMD MEDLINE Link].

13. Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol. 2007 Jan. 2(1):162-74. [QxMD MEDLINE Link]. [Full Text].

14. Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol. 1983 Dec. 61 (12):1444-61. [QxMD MEDLINE Link].

15. Kaplan LJ, Cheung NH, Maerz L, et al. A physicochemical approach to acid-base balance in critically ill trauma patients minimizes errors and reduces inappropriate plasma volume expansion. J Trauma. 2009 Apr. 66(4):1045-51. [QxMD MEDLINE Link].

16. Fontana V, Santinelli S, Internullo M, Marinelli P, Sardo L, Alessandrini G, et al. Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients. Eur Rev Med Pharmacol Sci. 2016. 20 (1):37-43. [QxMD MEDLINE Link].

17. Faisy C, Meziani F, Planquette B, Clavel M, Gacouin A, Bornstain C, et al. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. JAMA. 2016 Feb 2. 315 (5):480-8. [QxMD MEDLINE Link].

18. Rialp Cervera G, Raurich Puigdevall JM, Morán Chorro I, Martín Delgado MC, Heras la Calle G, Mas Serra A, et al. Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial. Pulm Pharmacol Ther. 2017 Jun. 44:30-37. [QxMD MEDLINE Link].

19. Tanios BY, Omran MO, Noujeim C, Lotfi T, Mallat SS, Bou-Khalil PK, et al. Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2018 Oct 29. 22 (1):275. [QxMD MEDLINE Link]. [Full Text].

20. Nuñez-Gonzalez L, Carrera N, Garcia-Gonzalez MA. Molecular Basis, Diagnostic Challenges and Therapeutic Approaches of Bartter and Gitelman Syndromes: A Primer for Clinicians. Int J Mol Sci. 2021 Oct 22. 22 (21):[QxMD MEDLINE Link]. [Full Text].

21. Guffey JD, Haas CE, Crowley A, Connor KA, Kaufman DC. Hydrochloric Acid Infusion for the Treatment of Metabolic Alkalosis in Surgical Intensive Care Unit Patients. Ann Pharmacother. 2018 Jun. 52 (6):522-526. [QxMD MEDLINE Link].

22. Gennari FJ. Pathophysiology of metabolic alkalosis: a new classification based on the centrality of stimulated collecting duct ion transport. Am J Kidney Dis. 2011 Oct. 58(4):626-36. [QxMD MEDLINE Link].

Christie P Thomas, MBBS, FRCP, FASN, FAHA Professor, Department of Internal Medicine, Division of Nephrology, Departments of Pediatrics and Obstetrics and Gynecology, Medical Director, Kidney and Kidney/Pancreas Transplant Program, University of Iowa Hospitals and Clinics

Christie P Thomas, MBBS, FRCP, FASN, FAHA is a member of the following medical societies: American College of Physicians, American Heart Association, American Society of Nephrology, Royal College of Physicians

Disclosure: Nothing to disclose.

Sameer Yaseen, MD Staff Nephrologist, Department of Internal Medicine, Division of Nephrology, Mercy Hospital of Des Moines

Sameer Yaseen, MD is a member of the following medical societies: Renal Physicians Association, American Society of Nephrology

Disclosure: Nothing to disclose.

Vecihi Batuman, MD, FASN Professor of Medicine, Section of Nephrology-Hypertension, Deming Department of Medicine, Tulane University School of Medicine

Vecihi Batuman, MD, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Eleanor Lederer, MD Professor of Medicine, Chief, Nephrology Division, Director, Nephrology Training Program, Director, Metabolic Stone Clinic, Kidney Disease Program, University of Louisville School of Medicine; Consulting Staff, Louisville Veterans Affairs Hospital

Eleanor Lederer, MD is a member of the following medical societies: American Association for the Advancement of Science, American Federation for Medical Research, American Society for Biochemistry and Molecular Biology, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Transplantation, International Society of Nephrology, Kentucky Medical Association, National Kidney Foundation, and Phi Beta Kappa

Disclosure: Dept of Veterans Affairs Grant/research funds Research

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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