Tubulointerstitial Nephritis Differential Diagnoses

Updated: Apr 30, 2020
  • Author: A Brent Alper, Jr, MD, MPH; Chief Editor: Vecihi Batuman, MD, FASN  more...
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DDx

Diagnostic Considerations

When evaluating patients with suspected tubulointerstitial nephritis, other problems to be considered include the following:

  • Tubular necrosis
  • Gomerulonephritis
  • Vasculitis
  • Atheroembolic disease
  • Radiation nephritis
  • Toxic nephropathies.

Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare disorder characterized by the combination of tubulointerstitial nephritis with bilateral anterior uveitis of sudden onset. In approximately 65% of cases the nephritis precedes the uveitis; in 20% the uveitiis occurs first, and in 15% the two conditions occur simultaneously. Patients are typically younger than 20 years old; many are girls. [17] TINU is thought to be an autoimmune process. It may be precipitated by drugs or infections, but many cases are idiopathic. A human leukocyte antigen (HLA)–related genetic predisposition has been reported. [18, 19]

 

Differential Diagnoses