Tubulointerstitial Nephritis Questions & Answers

Updated: Sep 23, 2018
  • Author: A Brent Alper, Jr, MD, MPH; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is tubulointerstitial nephritis?

What is the pathophysiology of tubulointerstitial nephritis?

What causes tubulointerstitial nephritis?

What causes acute tubulointerstitial nephritis?

What causes chronic tubulointerstitial nephritis?

What is the role of lead in the etiology of tubulointerstitial nephritis?

What causes obstructive uropathy in tubulointerstitial nephritis?

What is the role of Sjögren syndrome in the etiology of tubulointerstitial nephritis?

What is the role of Balkan endemic nephropathy, in the etiology of tubulointerstitial nephritis?

What is the role of aristolochic acid in the etiology of tubulointerstitial nephritis?

What is the prevalence of tubulointerstitial nephritis?

What is the prognosis of tubulointerstitial nephritis?

Presentation

Which clinical history findings are characteristic of tubulointerstitial nephritis?

What are the signs and symptoms of acute tubulointerstitial nephritis?

Which drugs may induce acute tubulointerstitial nephritis?

What are the signs and symptoms of NSAID-related acute tubulointerstitial nephritis?

What are the signs and symptoms of antibiotic-induced acute tubulointerstitial nephritis?

What are the infectious causes of acute tubulointerstitial nephritis?

What are the signs and symptoms of chronic tubulointerstitial nephritis?

What is analgesic nephropathy?

What is lithium nephropathy?

What are cyclosporine- and tacrolimus-induced nephropathy?

What are the signs and symptoms of lead nephropathy in tubulointerstitial nephritis?

What are the signs and symptoms of obstructive uropathy in tubulointerstitial nephritis?

What are atherosclerotic kidney diseases in patients with tubulointerstitial nephritis?

What is cholesterol microembolic disease in tubulointerstitial nephritis?

Which metabolic disorders are associated with tubulointerstitial nephritis?

What is Balkan endemic nephropathy?

DDX

Which conditions should be included in the differential diagnoses of tubulointerstitial nephritis?

What are the differential diagnoses for Tubulointerstitial Nephritis?

Workup

How is tubulointerstitial nephritis diagnosed?

What is the role of a complete blood count (CBC) with differential in the workup of tubulointerstitial nephritis?

What is the role of a chemistry panel in the workup of tubulointerstitial nephritis?

What is the role of urine studies in the workup of tubulointerstitial nephritis?

What is the role of ultrasonography in the workup of tubulointerstitial nephritis?

What is the role of IV pyelography in the workup of tubulointerstitial nephritis?

What is the role of CT scanning in the workup of tubulointerstitial nephritis?

What is the role of an EDTA lead mobilization test in the workup of tubulointerstitial nephritis?

What is the role of kidney biopsy in the workup of tubulointerstitial nephritis?

Which histologic findings are characteristic of tubulointerstitial nephritis?

Treatment

How is tubulointerstitial nephritis treated?

How is acute tubulointerstitial nephritis treated?

How is chronic tubulointerstitial nephritis treated?

How is analgesic nephropathy treated in tubulointerstitial nephritis?

How is cyclosporine/tacrolimus–induced renal failure treated in tubulointerstitial nephritis?

How is lead nephropathy treated in tubulointerstitial nephritis?

How are atherosclerotic kidney disease and cholesterol microembolic disease treated in patients with tubulointerstitial nephritis?

How is immunoglobulin G (IgG)-4–related disease treated in patients with tubulointerstitial nephritis?

Medications

What is the role of steroid therapy in the treatment of tubulointerstitial nephritis?

Which medications in the drug class Chelating agents are used in the treatment of Tubulointerstitial Nephritis?

Which medications in the drug class Glucocorticoids are used in the treatment of Tubulointerstitial Nephritis?