Light Chain-Associated Renal Disorders Questions & Answers

Updated: Sep 10, 2019
  • Author: Malvinder S Parmar, MBBS, MS, FRCPC, FACP, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is light chain nephropathy?

How is light chain nephropathy classified?

What is the pathophysiology of light chain nephropathy?

What is the pathophysiology of Fanconi syndrome (proximal tubular dysfunction)?

What is the pathophysiology of light chain deposition disease (LCDD)?

What is the pathophysiology of myeloma kidney (cast nephropathy)?

What is the pathophysiology of amyloidosis?

Which disorders are associated with light chain nephropathy?

Which patient groups have the highest prevalence of light chain nephropathy?

What is the prognosis of light chain nephropathy?

What is included in patient education about light chain nephropathy?

Presentation

Which clinical history findings are characteristic of light chain nephropathy?

Which physical findings are characteristic of light chain nephropathy?

DDX

What are the differential diagnoses for Light Chain-Associated Renal Disorders?

Workup

What is the role of urinalysis in the workup of light chain nephropathy?

What is the role of urine immunoelectrophoresis in the workup of light chain nephropathy?

What is the role of CBC count in the workup of light chain nephropathy?

What is the role of electrolyte panels in the workup of light chain nephropathy?

What is the role of a peripheral smear in the workup of light chain nephropathy?

What is the role of serum calcium measurement in the workup of light chain nephropathy?

What is the role of serum protein electrophoresis and immunoelectrophoresis in the workup of light chain nephropathy?

What is the role of serum free-light chain assay in the workup of light chain nephropathy?

Which lab findings are characteristic of tubular dysfunction in light chain nephropathy?

What is the role of urine glucose testing in the workup of light chain nephropathy?

What does a finding of nephrotic-range proteinuria suggest in the workup of light chain nephropathy?

What is the role of serum albumin testing in the workup of light chain nephropathy?

What is the role of an erythrocyte sedimentation rate in the workup of light chain nephropathy?

What is the role of a hepatic profile in the workup of light chain nephropathy?

What is the role of serum creatinine testing in the workup of light chain nephropathy?

What is the role of renal ultrasound in the workup of light chain nephropathy?

What is the role of bone imaging in the workup of light chain nephropathy?

What is the role of biopsy in the workup of light chain nephropathy?

Which histologic findings are characteristic of Fanconi syndrome (proximal tubular dysfunction)?

Which histologic findings are characteristic of myeloma kidney (cast nephropathy)?

Which histologic findings are characteristic of light-chain deposition disease (LCDD)?

Which histologic findings are characteristic of immunoglobulin light-chain amyloidosis (AL)?

Treatment

How is light chain nephropathy treated?

How is light chain nephropathy treated in patients with Fanconi syndrome (proximal tubular dysfunction)?

How is distal tubular dysfunction treated in patients with light chain nephropathy?

How is amyloidosis treated in patients with light chain nephropathy?

How is light chain nephropathy treated in patients with multiple myeloma?

What is the role of stem cell transplantation in the treatment of light chain nephropathy?

How is tumor lysis syndrome treated in patients with light chain nephropathy?

How are urinary tract infections treated in patients with light chain nephropathy?

How is hyperviscosity treated in patients with light chain nephropathy?

How is myeloma cell infiltration treated in patients with light chain nephropathy?

How is renal failure treated in patients with light chain nephropathy?

What is the role of plasmapheresis in the treatment of light chain nephropathy?

What is the role of high-cutoff dialyzers in the treatment of light chain nephropathy?

What is the role of kidney transplantation in the treatment of light chain nephropathy?

How are the complications of light chain nephropathy treated?

Which specialist consultations are beneficial to patients with light chain nephropathy?

Which dietary modifications are used in the treatment of light chain nephropathy?

How is light chain nephropathy prevented?

Medications

What is the role of medications in the treatment of light chain nephropathy?

Which medications in the drug class Corticosteroids are used in the treatment of Light Chain-Associated Renal Disorders?

Which medications in the drug class Antineoplastic agents are used in the treatment of Light Chain-Associated Renal Disorders?