Polycystic Kidney Disease Questions & Answers

Updated: Apr 26, 2018
  • Author: Roser Torra, MD, PhD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is autosomal dominant polycystic kidney disease (ADPKD)?

What are the signs and symptoms of autosomal dominant polycystic kidney disease (ADPKD)?

What is included in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

What causes pain in autosomal dominant polycystic kidney disease (ADPKD)?

Which physical findings suggest autosomal dominant polycystic kidney disease (ADPKD)?

Which tests are performed in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of genetic testing in the diagnosis of autosomal dominant polycystic kidney disease (ADPKD)?

What are the stages of renal failure in autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of radiologic studies in the evaluation of autosomal dominant polycystic kidney disease (ADPKD)?

What are the ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease type 1(ADPKD1)?

What are the ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease (ADPKD) in patients with a family history but unknown genotype?

When can autosomal dominant polycystic kidney disease (ADPKD) be ruled out in at risk individuals older than 40 years?

What are the indications for MRA in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of surgery in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Which procedures may be required for the treatment of autosomal dominant polycystic kidney disease (ADPKD) with end-stage renal failure?

What is autosomal dominant polycystic kidney disease (ADPKD)?

How is autosomal dominant polycystic kidney disease (ADPKD) characterized?

What is the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of genetics in the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of urine-concentration in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of renal bleeding in the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD)?

What causes autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of polycystin 1 in the etiology of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of polycystin 2 in the etiology of autosomal dominant polycystic kidney disease (ADPKD)?

Where are polycystin 1 and polycystin 2 located in the kidneys?

What are the structures of polycystin 1 and polycystin 2 in autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of polycystin 1 and polycystin 2 interaction in the etiology of autosomal dominant polycystic kidney disease (ADPKD)?

Which genetic factor affects the severity of autosomal dominant polycystic kidney disease (ADPKD)?

How does the clinical manifestations of ADPKD1 differ from ADPKD2?

What is the prevalence of autosomal dominant polycystic kidney disease (ADPKD)?

How does the incidence of autosomal dominant polycystic kidney disease (ADPKD) vary among patient groups?

What is the prognosis of autosomal dominant polycystic kidney disease (ADPKD)?

What are the risk factors for progression of autosomal dominant polycystic kidney disease (ADPKD)?

What increases the risk for end-stage renal disease (ESRD) in autosomal dominant polycystic kidney disease (ADPKD)?

What is the difference in prognosis for ADPKD1 and ADPKD2?

What causes mortality in autosomal dominant polycystic kidney disease (ADPKD)?

What are the common cardiovascular causes of death in autosomal dominant polycystic kidney disease (ADPKD)?

What should be included in patient education for autosomal dominant polycystic kidney disease (ADPKD)?

What are screening recommendations for family members of patients with autosomal dominant polycystic kidney disease (ADPKD?)

Presentation

What are the signs and symptoms of autosomal dominant polycystic kidney disease (ADPKD)?

Which comorbid conditions may cause abdominal pain in patients with autosomal dominant polycystic kidney disease (ADPKD)?

What is the increased risk for aneurysm in autosomal dominant polycystic kidney disease (ADPKD)?

Why is abdominal pain a diagnostic challenge autosomal dominant polycystic kidney disease (ADPKD)?

Other than pain, what are the symptoms of early-stage autosomal dominant polycystic kidney disease (ADPKD)?

How is hematuria and hemorrhage characterized in autosomal dominant polycystic kidney disease (ADPKD)?

What is the prevalence of hypertension in autosomal dominant polycystic kidney disease (ADPKD)?

Which physical findings are characteristic of advanced or severe autosomal dominant polycystic kidney disease (ADPKD)?

Which physical findings are rare in autosomal dominant polycystic kidney disease (ADPKD)?

What is the most frequent complication autosomal dominant polycystic kidney disease (ADPKD)?

What are common extrarenal manifestations of autosomal dominant polycystic kidney disease (ADPKD)?

How is polycystic liver disease characterized in autosomal dominant polycystic kidney disease (ADPKD)?

Which patient groups are at highest risk for polycystic liver disease in autosomal dominant polycystic kidney disease (ADPKD)?

What causes portal hypertension in autosomal dominant polycystic kidney disease (ADPKD)?

What is the prevalence of cerebral aneurysms in autosomal dominant polycystic kidney disease (ADPKD)?

What is the cause of cerebral aneurysms rupture autosomal dominant polycystic kidney disease (ADPKD)?

What are the signs and symptoms of nephrolithiasis in autosomal dominant polycystic kidney disease (ADPKD)?

How is nephrolithiasis diagnosed in autosomal dominant polycystic kidney disease (ADPKD)?

DDX

Which conditions should be included in the differential diagnoses of autosomal dominant polycystic kidney disease (ADPKD)?

What are the differential diagnoses for Polycystic Kidney Disease?

Workup

What is the role of imaging in the diagnosis of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of lab studies in the diagnosis of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of urinary proteomic biomarkers in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of genetic testing in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

How is renal failure staged in autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of IV urography in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of barium enema in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

When should patients with autosomal dominant polycystic kidney disease (ADPKD) be screened for intracranial aneurysms?

What is the role of ultrasonography in the diagnosis of autosomal dominant polycystic kidney disease (ADPKD)?

How are the extrarenal features of autosomal dominant polycystic kidney disease (ADPKD) assessed?

What are the ultrasonographic diagnostic criteria for ADPKD1?

What are the ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease (ADPKD) in patients with a family history but unknown genotype?

What is the role of CT scanning in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of MRI in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of magnetic resonance angiography (MRA) in the workup of autosomal dominant polycystic kidney disease (ADPKD)?

Treatment

What is the role of pharmacologic therapy in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

What are the treatment options for end-stage renal disease in autosomal dominant polycystic kidney disease (ADPKD)?

When is antibiotic prophylaxis indicated in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Which metabolic conditions need to be managed in autosomal dominant polycystic kidney disease (ADPKD)?

How are intracranial aneurysms managed in autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of tolvaptan in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Which dietary modifications are beneficial in autosomal dominant polycystic kidney disease (ADPKD)?

What activity restrictions are beneficial in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

How is blood pressure managed in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

Which drugs are used to treat blood pressure in autosomal dominant polycystic kidney disease (ADPKD?)

What are considerations with the use of ACE inhibitors and ARBs in patients with autosomal dominant polycystic kidney disease (ADPKD)?

What is the prevalence of urinary tract infections (UTIs) in autosomal dominant polycystic kidney disease (ADPKD)?

Why must infections of the bladder, renal parenchyma, and cysts be differentiated in autosomal dominant polycystic kidney disease (ADPKD)?

How is hematuria treated in autosomal dominant polycystic kidney disease (ADPKD)?

How is abdominal pain treated in autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of surgery in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

What is the role of nephrectomy in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

How is hepatomegaly treated in patient with autosomal dominant polycystic kidney disease (ADPKD)?

How should a polycystic liver be treated in autosomal dominant polycystic kidney disease (ADPKD)?

What are possible complications of bilateral nephrectomy in autosomal dominant polycystic kidney disease (ADPKD)?

Which specialist consultations are needed for the management of autosomal dominant polycystic kidney disease (ADPKD)?

What are the long-term monitoring protocols for autosomal dominant polycystic kidney disease (ADPKD)?

Medications

What are the indications for use of tolvaptan in the treatment of autosomal dominant polycystic kidney disease (ADPKD)?

What is the drug of choice for managing hypertension in autosomal dominant polycystic kidney disease (ADPKD)?

What are the medications used to manage cyst infections in autosomal dominant polycystic kidney disease (ADPKD)?

Which medications are used to maintain electrolyte levels in autosomal dominant polycystic kidney disease (ADPKD)?

Which medications in the drug class Phosphate Binders are used in the treatment of Polycystic Kidney Disease?

Which medications in the drug class Antibiotics are used in the treatment of Polycystic Kidney Disease?

Which medications in the drug class Angiotensin II Receptor Antagonists are used in the treatment of Polycystic Kidney Disease?

Which medications in the drug class Angiotensin-Converting Enzyme Inhibitors are used in the treatment of Polycystic Kidney Disease?

Which medications in the drug class Vasopressin Antagonists are used in the treatment of Polycystic Kidney Disease?