Focal Segmental Glomerulosclerosis Differential Diagnoses

Updated: Oct 06, 2017
  • Author: Sreepada TK Rao, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Diagnostic Considerations

Distinguishing FSGS from minimal-change disease, mesangial proliferative glomerulonephritis, membranoproliferative glomerulonephritis, or membranous glomerulonephritis may be clinically difficult. Rarely, nephrotic syndrome may be the initial manifestation in patients with systemic lupus erythematosus. Young patients presenting with nephrotic syndrome due to amyloidosis of the kidneys (except in rare familial forms) is very uncommon. Although hematuria is the most common presentation in whites with IgA nephropathy, nephrotic syndrome and renal insufficiency may also be present.