Focal Segmental Glomerulosclerosis Questions & Answers

Updated: Dec 07, 2020
  • Author: Sreepada TK Rao, MD, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Questions & Answers

Overview

What is focal segmental glomerulosclerosis (FSGS)?

What are the signs and symptoms of focal segmental glomerulosclerosis (FSGS)?

How is focal segmental glomerulosclerosis (FSGS) diagnosed?

Which lab test results support a diagnosis of focal segmental glomerulosclerosis (FSGS)?

Which imaging findings support a diagnosis of focal segmental glomerulosclerosis (FSGS)?

How is a diagnosis of focal segmental glomerulosclerosis (FSGS) confirmed?

How is focal segmental glomerulosclerosis (FSGS) treated?

What is the pathophysiology of focal segmental glomerulosclerosis (FSGS)?

What is the pathologic classification of focal segmental glomerulosclerosis (FSGS)?

What is the role of genetics in the pathophysiology of focal segmental glomerulosclerosis (FSGS)?

What causes primary focal segmental glomerulosclerosis (FSGS)?

What causes secondary focal segmental glomerulosclerosis (FSGS)?

What is the prevalence of focal segmental glomerulosclerosis (FSGS)?

What mortality and morbidity is associated with focal segmental glomerulosclerosis (FSGS)?

What are the racial predilections for focal segmental glomerulosclerosis (FSGS)?

What are the sexual predilections for focal segmental glomerulosclerosis (FSGS)?

Which age groups have the highest prevalence of focal segmental glomerulosclerosis (FSGS)?

Presentation

Which clinical history findings are characteristic of focal segmental glomerulosclerosis (FSGS)?

What is the focus of the clinical history in the evaluation of secondary focal segmental glomerulosclerosis (FSGS)?

Which physical exam findings are characteristic of focal segmental glomerulosclerosis (FSGS)?

DDX

How is focal segmental glomerulosclerosis (FSGS) differentiated from other glomerular diseases in patients with nephrotic syndrome?

What is the role of serologic studies and biomarkers in the diagnosis of focal segmental glomerulosclerosis (FSGS)?

Which conditions are included in the differential diagnoses of focal segmental glomerulosclerosis (FSGS)?

Workup

What is the role of lab tests in the workup of focal segmental glomerulosclerosis (FSGS)?

Which histologic findings are characteristic of focal segmental glomerulosclerosis (FSGS)?

What is the role of ultrasonography in the workup of focal segmental glomerulosclerosis (FSGS)?

Treatment

How are primary and non-nephrotic secondary focal segmental glomerulosclerosis (FSGS) treated?

How is nephrotic secondary focal segmental glomerulosclerosis (FSGS) treated?

Which nonspecific therapies are used in the treatment of focal segmental glomerulosclerosis (FSGS)?

How is idiopathic focal segmental glomerulosclerosis (FSGS) treated?

What is the role of steroids in the treatment of focal segmental glomerulosclerosis (FSGS)?

How is refractory focal segmental glomerulosclerosis (FSGS) treated?

What is the role of calcineurin inhibitors in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of mycophenolate mofetil (MMF) in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of tacrolimus and sirolimus in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of rituximab in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of kidney transplantation in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of the Liposorber LA-15 System in the treatment of focal segmental glomerulosclerosis (FSGS)?

Which medications may be beneficial in the treatment of focal segmental glomerulosclerosis (FSGS)?

What is the role of adrenocorticotropic hormone (ACTH) gel in the treatment of focal segmental glomerulosclerosis (FSGS)?

How is focal segmental glomerulosclerosis (FSGS) treated in HIV-positive patients?

Which dietary modifications are used in the treatment of focal segmental glomerulosclerosis (FSGS)?

Medications

What is the role of medications in the treatment of focal segmental glomerulosclerosis (FSGS)?

Which medications in the drug class Immunosuppressants are used in the treatment of Focal Segmental Glomerulosclerosis?

Follow-up

What is included in the long-term monitoring of patients with focal segmental glomerulosclerosis (FSGS)?

What are the possible complications of focal segmental glomerulosclerosis (FSGS) treatments?

What is the prognosis for focal segmental glomerulosclerosis (FSGS)?

What is included in the patient education about focal segmental glomerulosclerosis (FSGS)?