Contrast-Induced Nephropathy Questions & Answers

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8. Lakhal K, Ehrmann S, Chaari A, et al. Acute Kidney Injury Network definition of contrast-induced nephropathy in the critically ill: incidence and outcome. J Crit Care. 2011 Dec. 26(6):593-9. [QxMD MEDLINE Link].

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10. Droppa M, Desch S, Blase P, et al. Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty. Clin Res Cardiol. 2011 Nov. 100(11):1037-43. [QxMD MEDLINE Link].

11. Ren L, Ji J, Fang Y, et al. Assessment of urinary N-acetyl-β-glucosaminidase as an early marker of contrast-induced nephropathy. J Int Med Res. 2011. 39(2):647-53. [QxMD MEDLINE Link].

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28. Wu MY, Lo WC, Wu YC, Lin TC, Lin CH, Wu MS, et al. The Incidence of Contrast-Induced Nephropathy and the Need of Dialysis in Patients Receiving Angiography: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2022. 9:862534. [QxMD MEDLINE Link]. [Full Text].

29. Powell SP, Chawla R, Bottinor W, Turlington J, Hopkinson DA, Patel K, et al. Race, contrast-induced nephropathy and long-term outcomes after coronary and peripheral angiography and intervention. Cardiovasc Revasc Med. 2018 Sep. 19 (6S):31-35. [QxMD MEDLINE Link].

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31. Abe M, Morimoto T, Akao M, et al. Relation of contrast-induced nephropathy to long-term mortality after percutaneous coronary intervention. Am J Cardiol. 2014 Aug 1. 114(3):362-8. [QxMD MEDLINE Link].

32. Briguori C, Colombo A, Airoldi F, et al. Gadolinium-based contrast agents and nephrotoxicity in patients undergoing coronary artery procedures. Catheter Cardiovasc Interv. 2006 Feb. 67(2):175-80. [QxMD MEDLINE Link].

33. Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004 Oct 6. 44(7):1393-9. [QxMD MEDLINE Link].

34. Bartholomew BA, Harjai KJ, Dukkipati S, et al. Impact of nephropathy after percutaneous coronary intervention and a method for risk stratification. Am J Cardiol. 2004 Jun 15. 93(12):1515-9. [QxMD MEDLINE Link].

35. Lin KY, Zheng WP, Bei WJ, et al. A novel risk score model for prediction of contrast-induced nephropathy after emergent percutaneous coronary intervention. Int J Cardiol. 2017 Mar 1. 230:402-12. [QxMD MEDLINE Link].

36. Yuksel Y, Kose S. Prognostic Nutritional Index Predicts Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome. Angiology. 2023 Sep. 74 (8):736-744. [QxMD MEDLINE Link].

37. Chang WT, Sun CK, Wu JY, Huang PY, Liu TH, Chang YJ, et al. Association of prognostic nutritional index with risk of contrast induced nephropathy: A meta-analysis. Front Nutr. 2023. 10:1154409. [QxMD MEDLINE Link]. [Full Text].

38. Moreau JF, Noel LH, Droz D. Proximal renal tubular vacuolization induced by iodinated contrast media, or so-called "osmotic nephrosis". Invest Radiol. 1993 Feb. 28(2):187-90. [QxMD MEDLINE Link].

39. Xu Y, Zheng X, Liang B, Gao J, Gu Z. Vitamins for prevention of contrast-induced acute kidney injury: a systematic review and trial sequential analysis. Am J Cardiovasc Drugs. 2018 Oct. 18(5):373-86. [QxMD MEDLINE Link].

40. Liu X, Hang Y, Shen L, et al. Prevention of contrast-induced nephropathy with prostaglandin E1 in patients undergoing percutaneous coronary procedures: A meta-analysis of 24 randomized controlled trials
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41. Subramaniam RM, Suarez-Cuervo C, Wilson RF, et al. Effectiveness of prevention strategies for contrast-induced nephropathy: a systematic review and meta-analysis. Ann Intern Med. 2016 Mar 15. 164(6):406-16. [QxMD MEDLINE Link].

42. Zaki HA, Bashir K, Iftikhar H, Alhatemi M, Elmoheen A. Evaluating the Effectiveness of Pretreatment With Intravenous Fluid in Reducing the Risk of Developing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis. Cureus. 2022 May. 14 (5):e24825. [QxMD MEDLINE Link]. [Full Text].

43. Solomon R. Radiocontrast-induced nephropathy. Semin Nephrol. 1998 Sep. 18(5):551-7. [QxMD MEDLINE Link].

44. Mueller C. Prevention of contrast-induced nephropathy with volume supplementation. Kidney Int Suppl. 2006 Apr. S16-9. [QxMD MEDLINE Link].

45. Pannu N, Wiebe N, Tonelli M. Prophylaxis strategies for contrast-induced nephropathy. JAMA. 2006 Jun 21. 295(23):2765-79. [QxMD MEDLINE Link].

46. Nijssen EC, Rennenberg RJ, Nelemans PJ, et al. Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet. 2017 Apr 1. 389(10076):1312-22. [QxMD MEDLINE Link].

47. Putzu A, Boscolo Berto M, Belletti A, et al. Prevention of contrast-induced acute kidney injury by furosemide with matched hydration in patients undergoing interventional procedures: a systematic review and meta-analysis of randomized trials. JACC Cardiovasc Interv. 2017 Feb 27. 10(4):355-63. [QxMD MEDLINE Link].

48. Friedewald VE, Goldfarb S, Laskey WK, et al. The editor's roundtable: contrast-induced nephropathy. Am J Cardiol. 2007 Aug 1. 100(3):544-51. [QxMD MEDLINE Link].

49. Qian G, Liu CF, Guo J, Dong W, Wang J, Chen YD. Prevention of contrast-induced nephropathy by adequate hydration combined with isosorbide dinitrate for patients with renal insufficiency and Congestive Heart Failure. Clin Cardiol. 2018 Jul 27. [QxMD MEDLINE Link]. [Full Text].

50. Yan Y, Ye M, Dong X, Chen Q, Hong H, Chen L, et al. Prevention of Contrast-Induced Nephropathy by Inferior Vena Cava Ultrasonography-Guided Hydration in Chronic Heart Failure Patients. Cardiology. 2021. 146 (2):187-194. [QxMD MEDLINE Link].

51. Pappy R, Stavrakis S, Hennebry TA, Abu-Fadel MS. Effect of statin therapy on contrast-induced nephropathy after coronary angiography: a meta-analysis. Int J Cardiol. 2011 Sep 15. 151(3):348-53. [QxMD MEDLINE Link].

52. Briasoulis A, Mallikethi-Reddy S, Sharma S, Briasouli AA, Afonso L. 3-Hydroxy-3-methylglutaryl-CoA reductase enzyme inhibitors for prevention of contrast-induced nephropathy: a meta-analysis of prospective randomized controlled studies. Am J Ther. 2015 Nov-Dec. 22(6):e158-66. [QxMD MEDLINE Link].

53. Barbieri L, Verdoia M, Schaffer A, Nardin M, Marino P, De Luca G. The role of statins in the prevention of contrast induced nephropathy: a meta-analysis of 8 randomized trials. J Thromb Thrombolysis. 2014 Nov. 38(4):493-502. [QxMD MEDLINE Link].

54. Yang Y, Wu YX, Hu YZ. Rosuvastatin treatment for preventing contrast-induced acute kidney injury after cardiac catheterization: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2015 Jul. 94(30):e1226. [QxMD MEDLINE Link].

55. From AM, Bartholmai BJ, Williams AW, et al. Sodium bicarbonate is associated with an increased incidence of contrast nephropathy: a retrospective cohort study of 7977 patients at Mayo Clinic. Clin J Am Soc Nephrol. 2008 Jan. 3(1):10-8. [QxMD MEDLINE Link].

56. Solomon R, Gordon P, Manoukian SV, et al for the BOSS Trial Investigators. Randomized trial of bicarbonate or saline study for the prevention of contrast-induced nephropathy in patients with CKD. Clin J Am Soc Nephrol. 2015 Sep 4. 10(9):1519-24. [QxMD MEDLINE Link].

57. Ali-Hassan-Sayegh S, Mirhosseini SJ, Rahimizadeh E, et al. Current status of sodium bicarbonate in coronary angiography: an updated comprehensive meta-analysis and systematic review. Cardiol Res Pract. 2015. 2015:690308. [QxMD MEDLINE Link]. [Full Text].

58. Timal RJ, Kooiman J, Sijpkens YWJ, de Vries JPM, Verberk-Jonkers IJAM, Brulez HFH, et al. Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease: The Kompas Randomized Clinical Trial. JAMA Intern Med. 2020 Feb 17. [QxMD MEDLINE Link].

59. Xu R, Tao A, Bai Y, Deng Y, Chen G. Effectiveness of N-acetylcysteine for the prevention of contrast-induced nephropathy: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2016 Sep 23. 5(9):[QxMD MEDLINE Link]. [Full Text].

60. Van Praet JT, De Vriese AS. Prevention of contrast-induced nephropathy: a critical review. Curr Opin Nephrol Hypertens. 2007 Jul. 16(4):336-47. [QxMD MEDLINE Link].

61. Hoffmann U, Fischereder M, Kruger B, et al. The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. J Am Soc Nephrol. 2004 Feb. 15(2):407-10. [QxMD MEDLINE Link].

62. Haase M, Haase-Fielitz A, Ratnaike S, et al. N-Acetylcysteine does not artifactually lower plasma creatinine concentration. Nephrol Dial Transplant. 2008 May. 23(5):1581-7. [QxMD MEDLINE Link].

63. Rodby RA. Preventing complications of radiographic contrast media: is there a role for dialysis?. Semin Dial. 2007 Jan-Feb. 20(1):19-23. [QxMD MEDLINE Link].

64. Cruz DN, Perazella MA, Bellomo R, et al. Extracorporeal blood purification therapies for prevention of radiocontrast-induced nephropathy: a systematic review. Am J Kidney Dis. 2006 Sep. 48(3):361-71. [QxMD MEDLINE Link].

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66. Marenzi G, Lauri G, Campodonico J, et al. Comparison of two hemofiltration protocols for prevention of contrast-induced nephropathy in high-risk patients. Am J Med. 2006 Feb. 119(2):155-62. [QxMD MEDLINE Link].

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Anita Basu, MD, FACP Assistant Professor of Medicine, University of Mississippi School of Medicine; Staff Nephrologist, GV (Sonny) Montgomery Veterans Affairs Medical Center

Anita Basu, MD, FACP is a member of the following medical societies: American College of Physicians, National Kidney Foundation

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Eleanor Lederer, MD, FASN Professor of Medicine, Chief, Nephrology Division, Director, Nephrology Training Program, Director, Metabolic Stone Clinic, Kidney Disease Program, University of Louisville School of Medicine; Consulting Staff, Louisville Veterans Affairs Hospital

Eleanor Lederer, MD, FASN is a member of the following medical societies: American Association for the Advancement of Science, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Transplantation, International Society of Nephrology, Kentucky Medical Association, National Kidney Foundation

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: American Society of Nephrology<br/>Received income in an amount equal to or greater than $250 from: Healthcare Quality Strategies, Inc.

Vecihi Batuman, MD, FASN Professor of Medicine, Section of Nephrology-Hypertension, Deming Department of Medicine, Tulane University School of Medicine

Vecihi Batuman, MD, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Renu Bansal, MD Resident Physician, Department of Internal Medicine, University of Connecticut School of Medicine

Disclosure: Nothing to disclose.

Andre A Kaplan, MD, FACP, FASN Professor of Medicine, University of Connecticut School of Medicine; Director of Dialysis Program, Chief of Blood Purification, John Dempsey Hospital; Medical Director, UConn Dialysis Center; Medical Director, McDougal Correctional Institution Dialysis Unit

Andre A Kaplan, MD, FACP, FASN is a member of the following medical societies: American College of Physicians, American Society for Artificial Internal Organs, American Society of Nephrology, International Society of Nephrology, National Kidney Foundation, New York Academy of Medicine, American Society for Apheresis, Renal Physicians Association

Disclosure: Nothing to disclose.

Fabio Aglieco, DO Nephrologist and Internal Medicine Primary Care Provider, Nephrology Leaders and Associates; Medical Director, Brazoria County Dialysis Center

Fabio Aglieco, DO is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

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