Small-Incision Lenticule Extraction (ReLEx SMILE) Medication

Updated: Jun 26, 2017
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: Michael Taravella, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.


Corticosteroids, Ophthalmic

Class Summary

Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. In addition, these agents modify the body's immune response to diverse stimuli.

Prednisolone ophthalmic (Omnipred, Pred Forte, Pred MIld)

Prednisolone is used to treat acute inflammation following eye surgery or other insults to the eye. It decreases inflammation and corneal neovascularization, suppresses migration of polymorphonuclear leukocytes, and reverses increased capillary permeability.

Dexamethasone ophthalmic (Maridex)

Dexamethasone is used for various allergic and inflammatory diseases. It decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.


Antibiotics, Ophthalmic

Class Summary

Antimicrobial therapy must be comprehensive and cover all likely pathogens in the context of this clinical setting.

Moxifloxacin ophthalmic (Moxeza, Vigamox)

Moxifloxacin is indicated for treating bacterial conjunctivitis. It inhibits topoisomerase II (DNA gyrase) and IV enzymes. DNA gyrase is essential in bacterial DNA replication, transcription, and repair. Topoisomerase IV plays a key role in chromosomal DNA portioning during bacterial cell division.

Ofloxacin ophthalmic (Ocuflox)

Ofloxacin is a pyridine carboxylic acid derivative with broad-spectrum bactericidal effect. It inhibits bacterial growth by inhibiting DNA gyrase. It is indicated for superficial ocular infections of conjunctiva or cornea due to susceptible microorganisms.

Trimethoprim/polymyxin B ophthalmic (Polytrim Ophthalmic Solution)

This combination is used for ocular infection of the cornea or conjunctiva caused by susceptible microorganisms.

Ciprofloxacin ophthalmic (Ciloxan)

Ciprofloxacin has activity against Pseudomonas and Streptococcus species, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, and most gram-negative organisms; it has no activity against anaerobes.


Ophthalmic Lubricants

Class Summary

Sodium hyaluronate