Macrocephaly Medication

Updated: Aug 23, 2021
  • Author: Sumaira Nabi, MBBS, FCPS; Chief Editor: George I Jallo, MD  more...
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Medication Summary

Pharmacotherapy may be necessary to address other symptoms that may be seen in conditions involving macrocephaly, with goals of reducing morbidity and preventing complications. For instance, antiseizure medication may be required in children with macrocephaly and seizures. The choice of medication depends on the seizure type. 


Anticonvulsants, Other

Class Summary

These agents prevent seizure recurrence and terminate clinical and electrical seizure activity.

Valproic acid (Depacon, Depakene, Stavzor)

Valproic acid can be instituted in macrocephalic children with recurrent generalized seizures. It is easily available, inexpensive, and often confers good seizure control. Other drugs which are "broad-spectrum," effective in treating primary generalized or focal-onset seizures, include levetiracetam, topiramate, lamotrigine. 

Levetiracetam (Keppra, Keppra XR, Spritam, Roweepra)

The mechanism of action of levetiracetam is unknown. It is indicated for primary generalized tonic-clonic seizures in adults and children aged 6 years or older, as well as for use in juvenile myoclonic epilepsy and for partial seizures.

Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Tegretol-XR)

Carbamazepine is a tricyclic compound extensively metabolized to its active metabolite, carbamazepine-epoxide. This agent markedly induces its own metabolism and is highly bound to plasma proteins. It is effective towards preventing focal-onset seizures, and may exacerbate primary generalized seizures.

Topiramate (Qudexy XR, Topamax, Trokendi XR)

An antiepileptic drug with a broad spectrum of antiepileptic activity, topiramate is approved for generalized tonic-clonic seizures. It has multiple mechanisms of action, including state-dependent sodium channel blocking action; it also potentiates inhibitory activity of the neurotransmitter GABA. It may block glutamate activity and also is a carbonic anhydrase inhibitor.