Hydatidiform Mole Medication

Updated: Apr 08, 2021
  • Author: Lisa E Moore, MD, MS, FACOG, RDMS; Chief Editor: Leslie M Randall, MD, MAS, FACS  more...
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Medication Summary

Prophylactic chemotherapy after evacuation of a hydatidiform mole is not routinely recommended. [54] Only 20% of women with hydatidiform mole will develop malignant sequelae (ie, Gestational Trophoblastic Neoplasia). Prophylactic chemotherapy may be considered in patients who will not adhere to the required close follow-up.

A study by Zhao et al that included 171 patients with complete hydatidiform mole reported that prophylactic total hysterectomy had the lowest incidence of post-molar gestational trophoblastic neoplasia (11.4%) compared to expectant management (37.1%) and prophylactic chemotherapy (41.7%). [55]