Ovarian Cysts Medication

Updated: Dec 20, 2018
  • Author: Shannon M Grabosch, MD; Chief Editor: Nicole W Karjane, MD  more...
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Medication

Medication Summary

Narcotic analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs) can be used for pain relief in patients with ovarian cysts. NSAIDs, including ibuprofen and ketorolac, can be used to treat mild to moderate pain, while narcotic medications, such as morphine sulfate and oxycodone, are useful against moderate to severe pain.

As previously discussed, oral contraceptive pills (OCPs) protect against the development of functional ovarian cysts but cannot be used to resolve existing ones.

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Opioid Analgesics

Class Summary

These agents are used to relieve moderate to severe pain. Pain relief is of paramount concern, but it must be remedied with agents chosen for the given clinical situation.

A review of opioid equivalents and conversions may be found in the following reference article:

 http://emedicine.medscape.com/article/2138678-overview

Morphine sulfate (Astramorph, MS Contin, Avinza, Kadian, Duramorph, Infumorph, MorphaBond, Arymo ER)

Morphine sulfate is the drug of choice (DOC) for analgesia, owing to the drug's reliable and predictable effects, safety profile, and ease of reversibility with naloxone. Various intravenous (IV) doses are used; the drug is commonly titrated until the desired effect is obtained.

For chronic severe pain unremitting to alternative therapy, oral immediate–release and extended-release morphine sulfate may be warranted.  Arymo ER is a morphine sulfate abuse-deterrent derivative.

Oxycodone (OxyContin, Oxecta, Roxicodone, Oxaydo, Xtampza ER)

Oxycodone is indicated for the relief of moderate to severe pain. It inhibits ascending pain pathways by binding to the opiate receptor. It alters the response to and perception of pain. It produces generalized CNS depression.

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Analgesic Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Class Summary

These agents are used for the relief of mild to moderate pain. They inhibit inflammatory reactions and pain by decreasing the activity of cyclo-oxygenase (COX), which results in decreased prostaglandin synthesis.

Ibuprofen (Advil, Motrin, Caldolor, Addaprin, Children's Motrin Jr Strength, EnovaRX-Ibuprofen, Genpril, Goodsense Ibuprofen Children's, I-Prin, IBU-200, Ibuprofen Comfort Pac, KS Ibuprofen, Neoprofen, Provil)

Ibuprofen is the DOC for patients with mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Indomethacin (Indocin,Tivorbex)

It is used for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of COX, which results in a decrease of prostaglandin synthesis.

Naproxen (Naprosyn, Naprelan, Aleve, Anaprox, All Day Pain Relief, EC-Naprosyn, Equipto-Naproxen, Flanax Pain Relief, Goodsense Naproxen Sodium, Mediproxen, Naprelan, Naproderm)

Naproxen is used for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of COX, which results in a decrease of prostaglandin synthesis.

Diclofenac (Voltaren, Cataflam XR, Zipsor, Cambia, Dyloject, Zorvolex)

Diclofenac inhibits prostaglandin synthesis by decreasing COX activity, which, in turn, decreases formation of prostaglandin precursors.

Ketoprofen (Active-Ketoprofen, Ketophene Radidpaq)

Ketoprofen is used for relief of mild to moderate pain and inflammation. Small dosages are indicated initially in small patients, elderly patients, and patients with renal or liver disease. Doses higher than 75 mg do not increase the therapeutic effects. Administer high doses with caution, and closely observe the patient's response.

Ketorolac (ReadySharp Ketorolac)

Ketorolac inhibits prostaglandin synthesis by decreasing the activity of COX, which results in decreased formation of prostaglandin precursors.

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