Twin-to-Twin Transfusion Syndrome Differential Diagnoses

Updated: Aug 03, 2018
  • Author: Terence Zach, MD; Chief Editor: Ronald M Ramus, MD  more...
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Diagnostic Considerations

Important considerations

Monochorionic twin pregnancies are considered high-risk situations and require very close obstetrical monitoring. Newborns with twin-to-twin transfusion syndrome (TTTS) may be critically ill at birth and require specialized care in neonatal intensive care units. These infants are at significant risk for neurologic sequelae.

Other problems to be considered

The following conditions should also be considered in the differential diagnosis in cases of suspected TTTS:

  • Hydrops fetalis

  • Polycythemia

  • Polycythemia of the newborn

  • Polyhydramnios

  • Oligohydramnios

  • Anemia of the newborn