Fibrolamellar Carcinoma Differential Diagnoses

Updated: Jan 08, 2020
  • Author: Michael A Choti, MD, MBA, FACS; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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DDx

Diagnostic Considerations

All hepatic tumors that may demonstrate a scar are as follows [35] :

  • Focal nodular hyperplasia (FNH)

  • Hepatocellular adenoma

  • Hepatocellular carcinoma (HCC)

  • Intrahepatic cholangiocarcinoma (ICC)

  • Giant hemangioma

  • Hepatic metastasis

Case reports of synchronous or metachronous liver tumors in patients with fibrolamellar carcinoma (FLC) are as follows:

  • Focal nodular hyperplasia [36, 37, 38, 39]

  • Hepatic adenoma

  • Typical hepatocellular carcinoma, synchronous [40, 41, 42, 43, 44] or metachronous (initially thought to be fibrolamellar carcinoma recurrence) [45, 46]

  • Intrahepatic cholangiocarcinoma [47]

Differential Diagnoses