Fibrolamellar Carcinoma Differential Diagnoses

Updated: Sep 17, 2015
  • Author: Michael A Choti, MD, MBA, FACS; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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DDx

Diagnostic Considerations

All hepatic tumors that may demonstrate a scar are as follows [33] :

  • Focal nodular hyperplasia (FNH)
  • Hepatocellular adenoma
  • Hepatocellular carcinoma (HCC)
  • Intrahepatic cholangiocarcinoma (ICC)
  • Giant hemangioma
  • Hepatic metastasis

Case reports of synchronous or metachronous liver tumors in patients with fibrolamellar carcinoma (FLC) are as follows:

  • Focal nodular hyperplasia [11, 12, 13, 14]
  • Hepatic adenoma
  • Typical hepatocellular carcinoma, synchronous [34, 35, 36, 37, 38] or metachronous (initially thought to be fibrolamellar carcinoma recurrence) [39, 40]
  • Intrahepatic cholangiocarcinoma [41]

Differential Diagnoses