Fibrolamellar Carcinoma Questions & Answers

Updated: Jan 08, 2020
  • Author: Michael A Choti, MD, MBA, FACS; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Questions & Answers

Overview

What is fibrolamellar carcinoma (FLC)?

What distinguishes fibrolamellar carcinoma (FLC) from hepatocellular carcinoma?

What other names have been used to describe fibrolamellar carcinoma (FLC)?

What is the pathophysiology of fibrolamellar carcinoma (FLC)?

What causes fibrolamellar carcinoma (FLC)?

What is the US prevalence of fibrolamellar carcinoma (FLC)?

Which patient groups have the highest prevalence of fibrolamellar carcinoma (FLC)?

What is the prognosis of fibrolamellar carcinoma (FLC)?

Presentation

What are the signs and symptoms of fibrolamellar carcinoma (FLC)?

Which physical findings are characteristic of fibrolamellar carcinoma (FLC)?

DDX

Which conditions are included in the differential diagnoses of fibrolamellar carcinoma (FLC)?

What are the differential diagnoses for Fibrolamellar Carcinoma?

Workup

What is the role of hepatic enzyme tests in the workup of fibrolamellar carcinoma (FLC)?

Which circulating tumor markers are used in the diagnosis of fibrolamellar carcinoma (FLC)?

Omit

What is the role of abdominal radiographs in the workup of fibrolamellar carcinoma (FLC)?

What is the role of CT scans in the workup of fibrolamellar carcinoma (FLC)?

What is the role of MRI in the workup of fibrolamellar carcinoma (FLC)?

What is the role of ultrasonography in the workup of fibrolamellar carcinoma (FLC)?

What is the role of angiography in the workup of fibrolamellar carcinoma (FLC)?

What is the role of PET scans in the workup of fibrolamellar carcinoma (FLC)?

What is the role of FNAB in the workup of fibrolamellar carcinoma (FLC)?

What is the role of core needle biopsy in the workup of fibrolamellar carcinoma (FLC)?

Which histologic findings are characteristic of fibrolamellar carcinoma (FLC)?

How is fibrolamellar carcinoma (FLC) staged?

Treatment

How is fibrolamellar carcinoma (FLC) treated?

What is the role of chemotherapy in the treatment of fibrolamellar carcinoma (FLC)?

What is the role of surgery in the treatment of fibrolamellar carcinoma (FLC)?

What is the role of hepatic resection in the treatment of fibrolamellar carcinoma (FLC)?

What is the role of liver transplantation in the treatment of fibrolamellar carcinoma (FLC)?