Gastric Cancer Questions & Answers

Updated: May 21, 2019
  • Author: Elwyn C Cabebe, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Questions & Answers

Overview

What is gastric cancer?

Which histologic findings are characteristic of gastric cancer?

What are the signs and symptoms of gastric cancer?

What are late complications of gastric cancer?

Which lab tests are performed in the diagnosis of gastric cancer?

What is the role of imaging studies in the diagnosis of gastric cancer?

What are the surgical options for the treatment of gastric cancer?

Which medications are used in the management of gastric cancer?

What are treatment options for gastric cancer?

What is gastric cancer?

What is the anatomy of the stomach relative to gastric cancer?

What are the most common stomach sites of gastric cancer?

What is the pathophysiology of gastric cancer?

What is the pathophysiology of the hematogenous and lymphatic spread of gastric cancer?

What is the incidence of gastric cancer in the US?

What is the global incidence of epidemiology of gastric cancer?

What is the mortality rate of gastric cancer in the US?

What are the racial predilections of gastric cancer?

How does the incidence of gastric cancer vary by sex?

How does the incidence of gastric cancer vary by age?

What is the prognosis of gastric cancer?

Presentation

At what disease stage is gastric cancer usually diagnosed?

What are the signs and symptoms of gastric cancer?

What are late complications of gastric cancer?

What are the physical findings suggestive of gastric cancer?

Which environmental factors implicated in the development of gastric cancer?

What is the role of diet in the etiology of gastric cancer?

What is the role of smoking in the etiology of gastric cancer?

What is the role of Helicobacter pylori infection in the etiology of gastric cancer?

What is the role of proton pump inhibitors (PPIs) in the etiology of gastric cancer?

What is the role of a previous gastric surgery in the etiology of gastric cancer?

What is the role of genetics in the etiology of gastric cancer?

What are risk factors for the development of gastric cancer?

What is the role of bisphosphonates in the etiology of gastric cancer?

What are complications of gastric cancer?

DDX

What are the differential diagnoses for Gastric Cancer?

Workup

Which studies are performed in the workup of gastric cancer?

What is the role of imaging studies in the workup of gastric cancer?

Which histologic findings indicate gastric cancer?

How is the primary tumor of gastric cancer staged in the TNM classification system?

How are regional lymph nodes in gastric cancer staged?

How are distant metastasis in gastric cancer staged?

What are the prognostic features of gastric cancer?

What are the stages of gastric cancer?

What are the survival rates for gastric cancer by stage?

What are the features of spread patterns in gastric cancer?

What is the role of lab studies in the management of gastric cancer?

What is the role of serum glycan in the workup of gastric cancer?

Treatment

What are the treatment options for gastric cancer?

What is the role of total gastrectomy in the management of gastric cancer?

What is the role of lymph node dissection in the management of gastric cancer?

What is the role of neoadjuvant chemotherapy in the management of gastric cancer?

What is the role of intraoperative radiotherapy in the management of gastric cancer?

What is the role of adjuvant radiotherapy in the management of gastric cancer?

What is the efficacy of combined treatments for gastric cancer?

What are treatment options for advanced unresectable gastric cancer?

What is the role of pembrolizumab (Keytruda) in the treatment of unresectable gastric cancer?

What is the role of genetic markers in the treatment of gastric cancer?

What is the role of trastuzumab in treatment of advanced unresectable gastric cancer?

What is the role of combined capecitabine and oxaliplatin (XELOX) in treatment of advanced unresectable gastric cancer?

What is the role of bevacizumab in treatment of advanced unresectable gastric cancer?

Which medical personnel provide consultation to patients with gastric cancer?

How is gastric cancer prevented?

Guidelines

What are guidelines for routine screening for gastric cancer in the US?

Which organizations have issued treatment guidelines for Helicobacter pylori infection for prevention of gastric cancer?

What are environmental risk factors for gastric cancer?

What are the treatment guidelines for precancerous conditions associated with gastric cancer?

What are the College of Gastroenterology (ACOG) treatment guidelines for H pylori infection?

What European Helicobacter Study Group guidelines for H pylori eradication to prevent gastric cancer?

What are the Canadian Association of Gastroenterology (CAG) guidelines for H pylori eradication to prevent gastric cancer?

What are hereditary syndromes with a predisposition for gastric cancer?

Which organizations have released guidelines for the evaluation and management of gastric cancer hereditary cancer predisposition syndromes?

What are NCCN guidelines for evaluation and management hereditary diffuse gastric cancer (HDGC)?

What are the International Gastric Cancer Linkage Consortium guidelines for the clinical management of hereditary diffuse gastric cancer (HDGC)?

What are the NCCN guidelines for gastric cancer screening in patients with Lynch syndrome (hereditary non-polyposis colorectal cancer)?

What are the US Multi-Society Task Force on Colorectal Cancer guidelines for the genetic evaluation and management of Lynch syndrome (hereditary non-polyposis colorectal cancer) with regard to gastric cancer?

What are the NCCN guidelines for gastric cancer screening in patients with familial adenomatous polyposis?

What are the NCCN guidelines for gastric cancer screening in patients with juvenile polyposis syndrome and Peutz-Jeghers syndrome?

What are the NCCN diagnostic guidelines for gastric cancer?

What are the major staging systems used for gastric cancer?

What are the NCCN treatment guidelines for early-stage (Tis, or T1a) gastric cancer?

What are the NCCN treatment guidelines for resectable cT1b and cT2 gastric cancer?

What are the NCCN treatment guidelines for surgically unresectable locoregional gastric cancer?

What are the ESMO/ESSO/ESTRO treatment guidelines for gastric cancer?

Medications

What are the goals of drug treatment for gastric cancer?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, VEGF Inhibitor are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Anti-HER2 are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Antimicrotubular (Taxanes) are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Topoisomerase Inhibitors are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Anthracycline are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Platinum Analog are used in the treatment of Gastric Cancer?

Which medications in the drug class Antineoplastics, Antimetabolite are used in the treatment of Gastric Cancer?

Which medications in the drug class Thymidine Analog are used in the treatment of Gastric Cancer?