Hurthle Cell Carcinoma (Oncocytic Carcinoma) Differential Diagnoses

Updated: Feb 07, 2023
  • Author: Serhat Aytug, MD, FACE; Chief Editor: Julie E Hallanger Johnson, MD, FACP, ECNU  more...
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Diagnostic Considerations

Hürthle cell adenoma is the principal consideration in the differential diagnosis of Hürthle cell carcinoma. Other problems to consider include the following:

  • Follicular adenoma
  • Metastatic tumors to the thyroid
  • Thyroid cysts
  • Thyrotoxicosis

Metastatic tumors to the thyroid are particularly likely to result from renal cell carcinoma, but may also originate from Hürthle cell tumors in other organs that harbor Hürthle cells, such as the following:

  • Salivary glands
  • Pharynx
  • Larynx
  • Trachea
  • Parathyroid gland
  • Esophagus
  • Pituitary
  • Liver

Differential Diagnoses