Hurthle Cell Carcinoma Questions & Answers

Updated: Jan 29, 2018
  • Author: Serhat Aytug, MD; Chief Editor: Neetu Radhakrishnan, MD  more...
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Questions & Answers

Overview

What is Hürthle cell carcinoma?

Which factors are prognostic indicators in Hürthle cell carcinoma?

What is the pathophysiology of Hürthle cell carcinoma?

What is the role of genetics in the pathophysiology of Hürthle cell carcinoma?

What is the prevalence of Hürthle cell carcinoma in the US?

What is the mortality and morbidity associated with Hürthle cell carcinoma?

What is the global prevalence of Hürthle cell carcinoma?

Which patient groups have the highest prevalence of Hürthle cell carcinoma?

Presentation

Which clinical features of Hürthle cell carcinoma increase the risk for malignancy?

Which clinical history findings are characteristic of Hürthle cell carcinoma?

Which thyroid and parathyroid conditions are associated with Hürthle cell carcinoma?

Which physical findings are characteristic of Hürthle cell carcinoma?

What causes Hürthle cell carcinoma?

DDX

Which conditions should be included in the differential diagnoses of Hürthle cell carcinoma?

What are the differential diagnoses for Hurthle Cell Carcinoma?

Workup

Which lab tests are performed in the workup of Hürthle cell carcinoma?

What is the role of imaging studies in the workup of Hürthle cell carcinoma?

What is the role of FNA in the workup of Hürthle cell carcinoma?

Which cytological features are characteristic of Hürthle cell carcinoma?

What is the role of a microRNA expression array in the workup of Hürthle cell carcinoma?

What is the role of gene-expression classifier testing in the workup of Hürthle cell carcinoma?

What are potential cytological markers of malignancy in Hürthle cell carcinoma?

How are cytologically diagnosed Hürthle cell carcinoma managed?

Which histologic findings are characteristic of Hürthle cell carcinoma?

How is Hürthle cell carcinoma staged?

Treatment

What is the role of external radiotherapy in the treatment of Hürthle cell carcinoma?

How is Hürthle cell carcinoma treated?

What is the role of radioactive iodine-131 in the treatment of Hürthle cell carcinoma?

What is the role of levothyroxine in the treatment of Hürthle cell carcinoma?

What is the role of chemotherapy in the treatment of Hürthle cell carcinoma?

What is the role of surgery in the treatment of Hürthle cell carcinoma?

What are the limitations of intraoperative frozen section exam for the diagnosis of Hürthle cell carcinoma?

What is included in postoperative care following surgery for Hürthle cell carcinoma?

Which specialist consultations are beneficial to patients with Hürthle cell carcinoma?

Which dietary and activity modifications are used in the treatment of Hürthle cell carcinoma?

Guidelines

What organizations have released guidelines for the diagnosis and treatment of Hürthle cell carcinoma?

What are the diagnostic guidelines for Hürthle cell carcinoma?

What are the AACE/AME/ETA guidelines for FNAB to diagnose Hürthle cell carcinoma?

What are the ATA and NCCN guidelines for FNAB to diagnose Hürthle cell carcinoma?

What the guidelines for use of serum calcitonin assays in the diagnosis of Hürthle cell carcinoma?

How common is Hürthle cell carcinoma compared to the other subtypes of thyroid cancer?

What are American Thyroid Associations (ATA) diagnostic guidelines for differentiated thyroid cancers?

How is malignancy risk assessed in Hürthle cell carcinoma?

What are the NCCN diagnostic guidelines for differentiated thyroid cancer?

What are the ATA treatment guidelines for Hürthle cell carcinoma?

What are the NCCN treatment guidelines for Hürthle cell carcinoma?

What are the NCCN guidelines for use of radioiodine therapy in the treatment of Hürthle cell carcinoma?

What are the ATA guidelines for us of radioiodine therapy in the treatment of Hürthle cell carcinoma?

What are the guidelines for use of levothyroxine for the treatment of Hürthle cell carcinoma?

Medications

What is the role of medications in the treatment of Hürthle cell carcinoma?

Which medications in the drug class Thyroid hormones are used in the treatment of Hurthle Cell Carcinoma?

Follow-up

What is included in long-term monitoring of Hürthle cell carcinoma?

When is a decrease in levothyroxine (T4) indicated in the treatment of Hürthle cell carcinoma?

What is the role of ultrasonography in the long-term monitoring of Hürthle cell carcinoma?

What is the role of thyroglobulin measurement in the long-term monitoring of Hürthle cell carcinoma?

What is the role of chest x-ray in the long-term monitoring of Hürthle cell carcinoma?

What is the role of iodine-131 total body scanning in the long-term monitoring of Hürthle cell carcinoma?

What is included in inpatient care for Hürthle cell carcinoma?

How is Hürthle cell carcinoma prevented?

What are the possible complications following surgery for Hürthle cell carcinoma?

What are the possible complications of Hürthle cell carcinoma?

What are possible genetic defects and infertility complications in patients with Hürthle cell carcinoma?

What is the prognosis of Hürthle cell carcinoma?

What should be included in patient education about Hürthle cell carcinoma?