Non-Small Cell Lung Cancer Questions & Answers

Updated: Nov 09, 2018
  • Author: Winston W Tan, MD, FACP; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Questions & Answers

Overview

What is non–small cell lung cancer (NSCLC)?

How frequently is non–small cell lung cancer (NSCLC) diagnosed with metastasis?

What are the most common signs and symptoms of non–small cell lung cancer (NSCLC)?

What are the metastatic signs and symptoms of non–small cell lung cancer (NSCLC)?

Which chest radiography findings suggest non–small cell lung cancer (NSCLC)?

How is the diagnosis of non–small cell lung cancer (NSCLC) confirmed?

What is the TNM (tumor-node-metastasis) staging system for non–small cell lung cancer (NSCLC)?

How is primary tumor (T) involvement in non–small cell lung cancer (NSCLC) staged?

How is lymph node (N) involvement in non–small cell lung cancer (NSCLC) staged?

How is metastatic (M) involvement in non–small cell lung cancer (NSCLC) staged?

What are the treatment options for non–small cell lung cancer (NSCLC)?

What is the role of surgery in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of radiation therapy in the treatment of non–small cell lung cancer (NSCLC)?

How is non–small cell lung cancer (NSCLC) categorized?

What is the prevalence of lung cancer in the US?

What is the mortality associated with non–small cell lung cancer (NSCLC)?

Why is the prognosis of non–small cell lung cancer (NSCLC) generally poor?

How frequently is non–small cell lung cancer (NSCLC) diagnosed in asymptomatic patients?

Why should a staging workup be performed in non–small cell lung cancer (NSCLC)?

What are the treatment options for non–small cell lung cancer (NSCLC)?

What treatment guidelines are available for non–small cell lung cancer (NSCLC)?

What are the major risk factors for non–small cell lung cancer (NSCLC)?

What is the role of the exposure to carcinogens in the pathophysiology of non–small cell lung cancer (NSCLC)?

What is the role of genetics in the pathophysiology of non–small cell lung cancer (NSCLC)?

What genetic factor may explain why non–small cell lung cancer (NSCLC) often fails to respond to treatment?

What is the prevalence of non–small cell lung cancer (NSCLC) among lung cancers?

How is the adenocarcinoma subtype of non–small cell lung cancer (NSCLC) characterized?

How is squamous cell carcinoma (SCC) subtype of non–small cell lung cancer (NSCLC) characterized?

How is large-cell carcinoma subtype of non–small cell lung cancer (NSCLC) characterized?

What are the causes of non–small cell lung cancer (NSCLC)?

How frequently is tobacco smoking the cause of non–small cell lung cancer (NSCLC)?

Other than smoking, what are the risk factors for non–small cell lung cancer (NSCLC)?

What is the global prevalence of smoking?

How does the incidence of non–small cell lung cancer (NSCLC) vary between smokers and nonsmokers?

What are the differences in non–small cell lung cancer (NSCLC) susceptibility between males and females?

How quickly does the risk for non–small cell lung cancer (NSCLC) decline after smoking cessation?

What genetic differences are seen in non–small cell lung cancer (NSCLC) of persons who have never smoked?

What is the role of asbestos exposure in the etiology of non–small cell lung cancer (NSCLC)?

What is the role of radon exposure in the etiology of non–small cell lung cancer (NSCLC)?

What is the role of HIV infection in the etiology of non–small cell lung cancer (NSCLC)?

Which metals and chemical elements may have an etiologic role in the development of non–small cell lung cancer (NSCLC)?

What is the role of diet in the etiology of non–small cell lung cancer (NSCLC)?

What is the prevalence of non–small cell lung cancer (NSCLC) in the US?

What is the global prevalence of non–small cell lung cancer (NSCLC)?

Which patient groups are at highest risk for non–small cell lung cancer (NSCLC)?

What is the racial predilections of non–small cell lung cancer (NSCLC)?

What are the survival rates for non–small cell lung cancer (NSCLC)?

What are prognostic factors for non–small cell lung cancer (NSCLC)?

What is the prognosis of in situ and stage I non–small cell lung cancer (NSCLC)?

What is the prognostic significance of oncogenic pathway in non–small cell lung cancer (NSCLC)?

What are the benefits of smoking cessation after the diagnosis of early-stage non–small cell lung cancer (NSCLC)?

What is the effect of hormone therapy on the prognosis of non–small cell lung cancer (NSCLC) in women?

What are the effect of daily aspirin on the mortality rates for non–small cell lung cancer (NSCLC)?

How does detection of circulating tumor cells (CTCs) affect the prognosis of non–small cell lung cancer (NSCLC)?

What is the risk of recurrence in patients treated for non–small cell lung cancer (NSCLC)?

What is included in patient education about non–small cell lung cancer (NSCLC)?

Presentation

What are the respiratory signs and symptoms of non–small cell lung cancer (NSCLC)?

How do the symptoms of non–small cell lung cancer (NSCLC) vary by subtype?

What are the symptoms of non–small cell lung cancer (NSCLC) due to locoregional spread?

What is the symptoms of endobronchial non–small cell lung cancer (NSCLC)?

What are the symptoms of mediastinal non–small cell lung cancer (NSCLC)?

What are the symptoms of pleural non–small cell lung cancer (NSCLC)?

What are the neurologic symptoms of non–small cell lung cancer (NSCLC)?

What are the symptoms of metastatic non–small cell lung cancer (NSCLC)?

What are the CNS signs and symptoms of non–small cell lung cancer (NSCLC)?

What are the vascular symptoms of non–small cell lung cancer (NSCLC)?

What are the musculoskeletal symptoms of non–small cell lung cancer (NSCLC)?

Which paraneoplastic syndromes may occur in non–small cell lung cancer (NSCLC)?

Which physical findings are characteristic of non–small cell lung cancer (NSCLC)?

What are common sites of distant metastasis in non–small cell lung cancer (NSCLC)?

Which physical findings in the head and neck regions are characteristic of non–small cell lung cancer (NSCLC)?

What are the signs of superior vena cava syndrome (SVCS) in non–small cell lung cancer (NSCLC)?

Which respiratory system findings are characteristic of non–small cell lung cancer (NSCLC)?

Which cardiovascular findings are characteristic of non–small cell lung cancer (NSCLC)?

Which GI findings are characteristic of non–small cell lung cancer (NSCLC)?

Which musculoskeletal findings are characteristic of non–small cell lung cancer (NSCLC)?

Which neurologic findings are characteristic of non–small cell lung cancer (NSCLC)?

Which physical findings are characteristic of paraneoplastic syndromes in non–small cell lung cancer (NSCLC)?

DDX

Which conditions should be included in the differential diagnoses of non–small cell lung cancer (NSCLC)?

What are the differential diagnoses for Non-Small Cell Lung Cancer?

Workup

How is a diagnosis of non–small cell lung cancer (NSCLC) confirmed?

What is included in a staging workup for non–small cell lung cancer (NSCLC)?

What is the role of ECG and pulmonary function testing in the workup of non–small cell lung cancer (NSCLC)?

Which lab studies are indicated in the workup of non–small cell lung cancer (NSCLC)?

Which electrolyte abnormalities are commonly identified during the workup for non–small cell lung cancer (NSCLC)?

What is the role of liver function tests in the workup of non–small cell lung cancer (NSCLC)?

What is the role of arterial blood gas (ABG) testing in the workup of non–small cell lung cancer (NSCLC)?

What is the role of chest radiography in the workup of non–small cell lung cancer (NSCLC)?

Which chest radiograph findings are characteristic of non–small cell lung cancer (NSCLC)?

What is the role of CT scanning in the workup of non–small cell lung cancer (NSCLC)?

What is the role of MRI in the workup of non–small cell lung cancer (NSCLC)?

What is the role of bone scintigraphy in the workup of non–small cell lung cancer (NSCLC)?

What is the role of positron emission tomography (PET) scanning in the workup of non–small cell lung cancer (NSCLC)?

What is the role of sputum cytologic studies in the workup of non–small cell lung cancer (NSCLC)?

What is the role of bronchoscopy in the workup of non–small cell lung cancer (NSCLC)?

What is the role of biopsy in the workup of non–small cell lung cancer (NSCLC)?

What is the role of needle thoracentesis in the workup of non–small cell lung cancer (NSCLC)?

What is the role of thoracoscopy in the workup of non–small cell lung cancer (NSCLC)?

What is the role of mediastinoscopy in the workup of non–small cell lung cancer (NSCLC)?

What is the role of molecular testing in the workup of non–small cell lung cancer (NSCLC)?

What are the guidelines for molecular testing in the workup of non–small cell lung cancer (NSCLC)?

How are molecular testing results used to guide treatment for non–small cell lung cancer (NSCLC)?

Which histologic findings indicate the squamous cell carcinoma (SCC) subtype of non–small cell lung cancer (NSCLC)?

Which histologic findings indicate the adenocarcinoma subtype of non–small cell lung cancer (NSCLC)?

What are preinvasive lesions of epithelial lung tumors in non–small cell lung cancer (NSCLC)?

What are invasive malignant lesions of epithelial lung tumors in non–small cell lung cancer (NSCLC)?

What is the most important prognostic indicator non–small cell lung cancer (NSCLC)?

What is the staging for primary tumor (T) involvement in non–small cell lung cancer (NSCLC)?

What is the staging for lymph node (N) involvement in non–small cell lung cancer (NSCLC)?

What is the staging for metastatic (M) involvement in non–small cell lung cancer (NSCLC)?

What is the stage grouping of the tumor-node-metastasis (TNM) staging system for non–small cell lung cancer (NSCLC)?

Which patient groups may require additional workup for non–small cell lung cancer (NSCLC)?

What is included in the workup of non–small cell lung cancer (NSCLC) in patients with CNS metastasis and known cancer?

What is included in the workup of non–small cell lung cancer (NSCLC) in patients with immunosuppression?

What is included in the workup of non–small cell lung cancer (NSCLC) in patients with Pancoast tumor?

What is included in the workup of non–small cell lung cancer (NSCLC) in patients with superior vena cava syndrome (SVCS)?

What is included in the workup of non–small cell lung cancer (NSCLC) in patients with Ogilvie intestinal pseudo-obstruction?

Who should be screened for non–small cell lung cancer (NSCLC)?

What are the National Comprehensive Cancer Network (NCCN) guidelines for non–small cell lung cancer (NSCLC) screening?

What are USPSTF guidelines for non–small cell lung cancer (NSCLC) screening?

What are the limitations of non–small cell lung cancer (NSCLC) screening?

Which risk models are preferred by the NCI and ACS for non–small cell lung cancer (NSCLC) screening?

Treatment

What are the treatment options for non–small cell lung cancer (NSCLC)?

When should palliative care be considered in the treatment of non–small cell lung cancer (NSCLC)?

What is included in emergency treatment for non–small cell lung cancer (NSCLC)?

What is the role of surgery in the treatment of non–small cell lung cancer (NSCLC)?

What is involved in preoperative evaluation of non–small cell lung cancer (NSCLC)?

What is the standard surgical approach for treatment of non–small cell lung cancer (NSCLC)?

What is the role of wedge resection/segmentectomy in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of video-assisted thoracoscopic surgery (VATS) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of mediastinal lymphadenectomy in the treatment of non–small cell lung cancer (NSCLC)?

What is included in the postoperative evaluation of non–small cell lung cancer (NSCLC), and what are the potential complications following surgery?

What is the role of radiation therapy in the treatment of non–small cell lung cancer (NSCLC)?

What are prognostic indicators of better outcome for hyperfractionated radiation therapy treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of radiotherapy for the treatment of unresectable stage III non–small cell lung cancer (NSCLC)?

What is stereotactic body radiotherapy (SBRT) for the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of stereotactic body radiotherapy (SBRT) for the treatment of non–small cell lung cancer (NSCLC)?

What is the role of radiofrequency ablation (RFA) for the treatment of non–small cell lung cancer (NSCLC)?

What is the role of 4-dimensional computed tomography (4DCT) scans in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of adjuvant radiation therapy in the treatment of non–small cell lung cancer (NSCLC)?

What has caused a paradigm shift in the approach to treatment of non–small cell lung cancer (NSCLC)?

How frequently is chemotherapy utilized in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of neoadjuvant chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

When is chemotherapy considered in the treatment of locally advanced non–small cell lung cancer (NSCLC)?

What are the advantages of chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

What are the response rates to chemotherapy in non–small cell lung cancer (NSCLC)?

What are the benefits of adjuvant chemotherapy for non–small cell lung cancer (NSCLC)?

What is the role of cisplatin in the treatment of advanced non–small cell lung cancer (NSCLC)?

What is recommended by ASCO as first-line treatment for non–small cell lung cancer (NSCLC)?

Which platinum-containing combination therapy is preferred in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of paclitaxel in the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of paclitaxel (Abraxane) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of platinum-based doublet chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

Which histologic factors affect chemotherapy responsiveness in patients with non–small cell lung cancer (NSCLC)?

What is the role of genetics in resistance to platinum-based chemotherapy for the treatment of non–small cell lung cancer (NSCLC)?

What are the indications for second-line chemotherapy for non–small cell lung cancer (NSCLC)?

What is the role of ramucirumab (Cyramza) in the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of second-line chemotherapy in the treatment of non–small cell lung cancer (NSCLC)?

What are possible adverse effects of chemotherapy for non–small cell lung cancer (NSCLC)?

What is the role of combination chemoradiation therapy for the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of combined chemoradiation therapy for the treatment of non–small cell lung cancer (NSCLC)?

Which chemotherapy regimens have been used in combination with radiation therapy for non–small cell lung cancer (NSCLC)?

What is the role of consolidation chemotherapy after chemoradiation in the treatment of non–small cell lung cancer (NSCLC)?

What is an effective combination therapy for the treatment of stage III non–small cell lung cancer (NSCLC)?

What is the role of durvalumab in the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of chemoradiation followed by surgical resection for the treatment of non–small cell lung cancer (NSCLC)?

What are the treatment options for non–small cell lung cancer (NSCLC) in patients with vascular endothelial growth factor (VEGF) mutations?

What are the treatment options for non–small cell lung cancer (NSCLC) in patients with ROS-1 mutations?

What is the role of osimertinib (Tagrisso) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of ceritinib in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of molecular-targeted therapy in the treatment of non–small cell lung cancer (NSCLC)?

What are options for targeted therapy in patients with non–small cell lung cancer (NSCLC) adenocarcinoma and endothelial growth factor receptor (EGFR) mutations?

What are first-line therapy options for patients with non–small cell lung cancer (NSCLC) adenocarcinoma and anaplastic lymphoma kinase (ALK) rearrangements?

How is non–small cell lung cancer (NSCLC) treated in patients with BRAF mutation?

What are the treatment options for non–small cell lung cancer (NSCLC) in patients with PD-1 ligand (PDL-1)?

What is the role of pembrolizumab (Keytruda) in the treatment of non–small cell lung cancer (NSCLC)?

How does overexpression of endothelial growth factor receptor (EGFR) affect the prognosis of non–small cell lung cancer (NSCLC)?

How common are endothelial growth factor receptor (EGFR) mutations in patients with advanced non–small cell lung cancer (NSCLC)?

What is the role of afatinib (Gilotrif) in the treatment of non–small cell lung cancer (NSCLC)?

What are serious adverse events of afatinib (Gilotrif) for treatment of non–small cell lung cancer (NSCLC)?

What is the method of action of gefitinib in the treatment of non–small cell lung cancer (NSCLC)?

When is gefitinib indicated in the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of gefitinib for the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of gefitinib versus docetaxel as second-line therapy for non–small cell lung cancer (NSCLC)?

What is the efficacy of gefitinib versus carboplatin-paclitaxel as first-line therapy for non–small cell lung cancer (NSCLC)?

What is the strongest predictor of progression-free survival and response to gefitinib in non–small cell lung cancer (NSCLC)?

What is the role of erlotinib in the treatment of non–small cell lung cancer (NSCLC)?

What are the benefits of erlotinib combined with chemotherapy for the treatment of non–small cell lung cancer (NSCLC)?

What is the efficacy of first-line treatment with erlotinib followed by cisplatin-gemcitabine in non–small cell lung cancer (NSCLC)?

What are the benefits of erlotinib combined with bevacizumab for the treatment of non–small cell lung cancer (NSCLC)?

What is the role of cetuximab in the treatment of non–small cell lung cancer (NSCLC)?

What are the treatment options for squamous cell non–small cell lung cancer (NSCLC) in patients with EGFR mutations?

What is the role of necitumumab in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of vandetanib in the treatment of non–small cell lung cancer (NSCLC)?

What are treatment options for adenocarcinoma and large cell lung cancer?

What is the role of bevacizumab (Avastin) in the treatment of non–small cell lung cancer (NSCLC)?

What are the response rates for bevacizumab in combination with cisplatin-gemcitabine as first-line therapy for nonsquamous non–small cell lung cancer (NSCLC)?

What is the efficacy of adding bevacizumab to platinum-based chemotherapy as first-line treatment of non–small cell lung cancer (NSCLC)?

What is the role of bevacizumab-awwb (Mvasi) in the treatment of non-squamous non–small cell lung cancer (NSCLC)?

What is the role of ramucirumab in the treatment of non–small cell lung cancer (NSCLC)?

How common are anaplastic lymphoma kinase (ALK) mutations in non–small cell lung cancer (NSCLC)?

What is the role of crizotinib (Xalkori) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of brigatinib (Alunbrig) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of alectinib in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of crizotinib in the treatment of non–small cell lung cancer (NSCLC)?

When are third-generation endothelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) indicated for the treatment of non–small cell lung cancer (NSCLC)?

What is the role of osimertinib in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of programmed cell death (PD-1) inhibitors in the treatment of non–small cell lung cancer (NSCLC) therapy?

What is the role of nivolumab (Opdivo) in the treatment of non–small cell lung cancer (NSCLC)?

What is the role of pembrolizumab (Keytruda) in the treatment of metastatic non–small cell lung cancer (NSCLC)?

What is the efficacy of pembrolizumab for the treatment of metastatic non–small cell lung cancer (NSCLC)?

What is the role of atezolizumab (Tecentriq) in the treatment of metastatic non–small cell lung cancer (NSCLC)?

What is the role of durvalumab in the treatment of stage III non–small cell lung cancer (NSCLC)?

What is the role of combination figitumumab, paclitaxel and carboplatin in the treatment of non–small cell lung cancer (NSCLC)?

What is BRAF-directed therapy for non–small cell lung cancer (NSCLC)?

What is the role of combined dabrafenib and trametinib in the treatment of non–small cell lung cancer (NSCLC)?

What are the ASCO recommendations for maintenance therapy for stage IV non–small cell lung cancer (NSCLC)?

What is the treatment of choice for stage I non–small cell lung cancer (NSCLC)?

How is non–small cell lung cancer (NSCLC) treated in patients who cannot undergo resection?

What is the role of postoperative radiation therapy in stage I and II non–small cell lung cancer (NSCLC)?

What is the role of adjuvant chemotherapy in non–small cell lung cancer (NSCLC)?

What is the treatment of choice for stage II non–small cell lung cancer (NSCLC)?

What are treatment options for stage IIIA non–small cell lung cancer (NSCLC)?

Which patients with stage IIIA non–small cell lung cancer (NSCLC) should be considered for definitive chemoradiation therapy?

What are the advantages of surgery versus radiation therapy following neoadjuvant chemotherapy for the treatment of stage IIIA non–small cell lung cancer (NSCLC)?

What is the role of adjuvant chemotherapy in the treatment of stage IIIA non–small cell lung cancer (NSCLC)?

What is the role of postoperative radiation therapy in patients with stage IIIA non–small cell lung cancer (NSCLC)?

What is the role of neoadjuvant cisplatin-based chemotherapy for the treatment of stage IIIA non–small cell lung cancer (NSCLC)?

What is the role of prophylactic cranial irradiation (PCI) in the treatment of non–small cell lung cancer (NSCLC)?

What is the treatment options for stage IIIB non–small cell lung cancer (NSCLC)?

What is the efficacy of treatments for stage IIIB non–small cell lung cancer (NSCLC)?

What are the treatment options for stage IIIB non–small cell lung cancer (NSCLC) and poor performance status?

What are the treatment options for advanced non–small cell lung cancer (NSCLC)?

What is the efficacy of treatments for stage IV non–small cell lung cancer (NSCLC)?

Which patients with stage IV non–small cell lung cancer (NSCLC) may be candidates for treatment with bevacizumab?

What is the role of maintenance non–cross-resistant chemotherapy in the treatment of stage IV non–small cell lung cancer (NSCLC)?

Which patients with stage IV non–small cell lung cancer (NSCLC) may benefit from treatment with gefitinib or erlotinib?

Which patients with stage IV non–small cell lung cancer (NSCLC) may be candidates for treatment with cytotoxic drugs?

Which patients with stage IV non–small cell lung cancer (NSCLC) should be considered for palliative care?

What are the ASCO recommendations for first-line therapy for stage IV non–small cell lung cancer (NSCLC)?

What are the ASCO recommendations for second-line therapy for stage IV non–small cell lung cancer (NSCLC)?

What are the ASCO recommendations for third-line therapy for stage IV non–small cell lung cancer (NSCLC)?

How is stage IV non–small cell lung cancer (NSCLC) treated in patients with large-cell neuroendocrine carcinoma?

How is activity level used in the prognosis of non–small cell lung cancer (NSCLC)?

How is non–small cell lung cancer (NSCLC) prevented?

What measures can be taken to decrease occupational exposure to carcinogens causing non–small cell lung cancer (NSCLC)?

Which patients should receive non–small cell lung cancer (NSCLC) screening?

Which specialist consultations are recommended for the management of non–small cell lung cancer (NSCLC)?

Which specialist consultations are recommended to address complications caused by spread of non–small cell lung cancer (NSCLC)?

What are the NCCN recommendations for cancer surveillance in survivors of non–small cell lung cancer (NSCLC)?

What are the NCCN recommendations for long-term monitoring of non–small cell lung cancer (NSCLC)?

Guidelines

Which organizations have issued guidelines for lung cancer screening?

What are recommendations for lung cancer screening?

What is included in the American College of Chest Physicians (ACCP) lung cancer guidelines?

What are the ACCP diagnostic guidelines for pleural abnormalities in non–small cell lung cancer (NSCLC)?

What are the ACCP recommendations for the diagnosis of primary tumor in lung cancer?

What are the ACCP recommendations for treatment of clinical stage I and II non–small cell lung cancer (NSCLC)?

What are ACCP recommendations for treatment of clinical stage III non–small cell lung cancer (NSCLC)?

What are the ACCP recommendations for treatment of stage IV non–small cell lung cancer (NSCLC)?

What are ACCP recommendations for palliative and end-of-life care for non–small cell lung cancer (NSCLC)?

What are NCCN recommendations for video-assisted thoracoscopy surgery (VATS) in non–small cell lung cancer (NSCLC)?

What are the ASCO recommendations for first-line therapy for negative or unknown tumor EGFR-sensitizing mutation, ALK or ROS1 gene rearrangement status in non–small cell lung cancer (NSCLC)?

What are the ASCO guidelines for chemotherapy for stage IV non–small cell lung cancer (NSCLC)?

What are cisplatin-based two-drug combinations for stage IV non–small cell lung cancer (NSCLC)?

What are carboplatin-based two-drug combinations for stage IV non–small cell lung cancer (NSCLC)?

What are ASCO recommendations for stage IV non–small cell lung cancer (NSCLC) receiving carboplatin plus paclitaxel?

What are the ASCO recommendations for treatment of stage IV non–small cell lung cancer (NSCLC) in patients with PS 2, non-SCC, and negative or unknown tumor EGFR-sensitizing mutation and ALK or ROS1 gene rearrangement status?

What are the ASCO recommendations for stage IV squamous cell carcinoma (SCC) non–small cell lung cancer (NSCLC)?

What are cisplatin-based two-drug combinations for stage IV squamous cell carcinoma (SCC) non–small cell lung cancer (NSCLC)?

What are carboplatin-based two-drug combinations for stage IV squamous cell carcinoma (SCC) non–small cell lung cancer (NSCLC)?

What are first-line options for treatment of stage IV squamous cell carcinoma (SCC) non–small cell lung cancer (NSCLC) in patients with a sensitizing endothelial growth factor receptor (EGFR) mutation?

What are ASCO recommendations for second-line therapy for patients with stage IV squamous cell carcinoma (SCC) and non-squamous cell carcinoma (SCC) non–small cell lung cancer (NSCLC)?

What are ASCO recommendations for second-line therapy for stage IV non–small cell lung cancer (NSCLC) in patients with sensitizing endothelial growth factor receptor (EGFR) mutation?

What are ASCO recommendations for second-line therapy of stage IV non–small cell lung cancer (NSCLC) in patients with ROS1 rearrangement?

What are ASCO recommendations for second-line therapy of stage IV non–small cell lung cancer (NSCLC) in patients with BRAF mutations?

What are ASCO recommendations for third-line therapy of stage IV non–small cell lung cancer (NSCLC)?

What is included in the American Society for Radiation Oncology (ASTRO) guidelines for radiation therapy for non–small cell lung cancer (NSCLC)?

What are ASTRO recommendations for curative-intent radiation therapy for locally advanced non–small cell lung cancer (NSCLC)?

What are ASTRO recommendations for adjunctive radiation therapy for non–small cell lung cancer (NSCLC)?

What are CAP/IASLC/AMP recommendations for endothelial growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) molecular testing in patients with non–small cell lung cancer (NSCLC)?

Medications

What is the role of drug treatment for non–small cell lung cancer (NSCLC)?

Which medications in the drug class Antineoplastics, MEK Inhibitors are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class Antineoplastics, BRAF Kinase Inhibitor are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class Antiemetic Agents are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class Antineoplastics, EGFR Inhibitor are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class PD-1/PD-L1 Inhibitors are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class Antineoplastics, Anaplastic Lymphoma Kinase Inhibitor are used in the treatment of Non-Small Cell Lung Cancer?

Which medications in the drug class Antineoplastic Agents are used in the treatment of Non-Small Cell Lung Cancer?