Pancreatic Cancer Questions & Answers

Updated: Mar 07, 2019
  • Author: Tomislav Dragovich, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Questions & Answers

Overview

How common is pancreatic cancer?

What are the signs and symptoms of pancreatic cancer?

What is the role of lab testing in the diagnosis of pancreatic cancer?

Which imaging studies are performed in the workup of pancreatic cancer?

How is pancreatic cancer treated?

Which surgical interventions are used in the treatment of pancreatic cancer?

Which chemotherapy agents are used in the treatment of pancreatic cancer?

Which neoadjuvant therapy regimens are used in the treatment of pancreatic cancer?

What is the role of palliative therapy in the treatment of pancreatic cancer?

What is the life-time risk for pancreatic cancer?

What are the survival rates for pancreatic cancer?

What are the types of pancreatic cancer?

What is the pathophysiology of pancreatic cancer?

What causes pancreatic cancer?

What is the role of smoking in the etiology of pancreatic cancer?

What is the role of obesity in the etiology of pancreatic cancer?

What is the role of diet in the etiology of pancreatic cancer?

What is the risk of diabetes mellitus (DM) in the etiology of pancreatic cancer?

What is the role of chronic pancreatitis in the etiology of pancreatic cancer?

What is the role of genetics in the etiology of pancreatic cancer?

Which patient groups are at highest risk for pancreatic cancer?

What is the incidence of pancreatic cancer in the US?

What is the global incidence of pancreatic cancer?

What is the racial predilection of pancreatic cancer?

Which age groups have the highest prevalence of pancreatic cancer by age?

What are the mortality rates for pancreatic cancer?

What is the prognosis of pancreatic cancer?

What is included in patient education about pancreatic cancer?

Presentation

Which clinical history findings are characteristic of pancreatic cancer?

What are the signs and symptoms of pancreatic cancer?

Which physical findings are characteristic of pancreatic cancer?

DDX

In which patients should a diagnosis of pancreatic cancer be considered?

How prevalent is regional spread or distant disease at diagnosis of pancreatic cancer?

Which disorders should be considered in the differential diagnoses of pancreatic cancer?

What are the differential diagnoses for Pancreatic Cancer?

Workup

Which tests are performed in the workup of pancreatic cancer?

How is chronic pancreatitis differentiated from pancreatic cancer?

What is the role of lab testing in the workup of pancreatic cancer?

What is the role of carbohydrate antigen 19-9 testing in the evaluation of pancreatic cancer?

What is the role of carcinoembryonic antigen testing in the evaluation of pancreatic cancer?

What is the role of tumor markers in the diagnosis of pancreatic cancer?

What is the role of CT scanning in the workup of pancreatic cancer?

What is the role of transcutaneous ultrasonography (TUS) in the workup of pancreatic cancer?

What is the role of endoscopic ultrasonography (EUS) in the workup of pancreatic cancer?

What is the role of endoscopic retrograde cholangiopancreatography in the workup of pancreatic cancer?

What is the role of MRI in the workup of pancreatic cancer?

What is the role of PET scanning in the workup of pancreatic cancer?

What is the role of fine needle aspiration (FNA) in the workup of pancreatic cancer?

Which morphologic characteristics are associated with pancreatic cancer?

Which histologic findings are characteristic of pancreatic cancer?

How are pancreatic masses characterized by surgeons?

How is pancreatic cancer staged?

What are stages of tumor (T) in pancreatic cancer?

What are stages of regional lymph nodes (N) in pancreatic cancer?

What are stages of distant metastasis (M) in pancreatic cancer?

What are the stages of pancreatic cancer?

Which imaging studies are used for staging of pancreatic cancer?

What is the role of preoperative staging laparoscopy in the management of pancreatic cancer?

What are the indications of staging laparoscopy in the management of pancreatic cancer?

What is the evaluation and treatment algorithm for pancreatic cancer?

Treatment

How is pancreatic cancer treated?

What are the NCCN guidelines for treatment selection in pancreatic cancer?

What are the ESMO treatment guidelines for pancreatic cancer?

What is the role of local ablation in the treatment of pancreatic cancer?

What is the role of chemotherapy in the treatment of pancreatic cancer?

What is the role of adjuvant therapy in the treatment of pancreatic cancer?

What is the role of neoadjuvant therapy in the treatment of pancreatic cancer?

What are the NCCN guidelines for neoadjuvant therapy for pancreatic cancer?

What is the efficacy of neoadjuvant therapy for the treatment of pancreatic cancer?

What is the role of pancreaticoduodenectomy (Whipple procedure) in the treatment of pancreatic cancer?

What are the ESMO guidelines for the use of pancreaticoduodenectomy (Whipple procedure) for the treatment of pancreatic cancer?

What is the role of distal pancreatectomy in the treatment of pancreatic cancer?

What is the role of total pancreatectomy in the treatment of pancreatic cancer?

How is pain managed in pancreatic cancer?

How is jaundice treated in pancreatic cancer?

How is duodenal obstruction treated in pancreatic cancer?

Which dietary modifications are used in the treatment of pancreatic cancer?

Which specialist consultations are beneficial to patients with pancreatic cancer?

Guidelines

Which organizations provide guidelines on pancreatic cancer screening?

What are the USPSTF and AAFP guidelines for pancreatic cancer screening?

What are international CAPS consortium guidelines for pancreatic cancer screening?

What are the guidelines for the use of tumor markers in pancreatic cancer?

According to NCCN guidelines, when should pancreatic cancer be considered in patients with diabetes mellitus?

What are the ESMO diagnostic guidelines for pancreatic cancer?

What are the NCCN diagnostic guidelines for pancreatic cancer?

What are the NCCN guidelines for staging laparoscopy in patients with pancreatic cancer?

What are the criteria for defining resectability status in pancreatic cancer?

What are the criteria for borderline resectable tumors in pancreatic cancer?

What are the ASCO recommendations for primary surgical resection in pancreatic cancer?

What are ASCO treatment guidelines for potentially curable pancreatic cancer?

What are the ASCO criteria for preoperative therapy of pancreatic cancer?

What are the ASCO guidelines for postoperative treatment of pancreatic cancer?

What are the ESMO treatment guidelines for pancreatic cancer?

What are the ESMO treatment guidelines for resectable pancreatic cancer?

What are the NCCN treatment guidelines for localized pancreatic cancer?

What are the NCCN guidelines for neoadjuvant therapy for pancreatic cancer?

What are the NCCN recommended neoadjuvant regimens for pancreatic cancer?

What are the ASCO treatment guidelines for locally advanced, unresectable pancreatic cancer?

What are the ESMO recommendations for treatment of locally advanced pancreatic cancer?

What are the NCCN treatment guidelines for locally advanced pancreatic cancer?

What are the ASCO treatment guidelines for metastatic pancreatic cancer?

What are the ESMO treatment guidelines for metastatic pancreatic cancer?

What are the NCCN treatment guidelines for metastatic pancreatic cancer?

What are the NCCN guidelines for the palliative care in pancreatic cancer?

What are the ACS guidelines for nutrition and physical activity in the treatment of pancreatic cancer?

Medications

Which medications are the most active in against pancreatic cancer?

Which medications in the drug class Antineoplastic agents are used in the treatment of Pancreatic Cancer?