Central Nervous System Germinoma Differential Diagnoses

Updated: May 04, 2015
  • Author: Amani A Al Kofide, MD; Chief Editor: Jules E Harris, MD, FACP, FRCPC  more...
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Diagnostic Considerations

Delay in diagnosis is a significant concern in central nervous system (CNS) germ cell tumors (GCTs). Sethi et al reported that diagnosis was delayed for 6 months or longer in 38 of 70 children with CNS GCTs. [34] Endocrine symptoms are very common in young patients with CNS GCTs and can appear long before neuroimaging verification is possible. [48] Delay in diagnosis has major implications on the prognosis and the risk of dissemination of disease.

Other problems to consider in the differential diagnosis include the following:

  • Glial Tumors - Astrocytomas, gangliomas
  • Granular cell tumor
  • Hamartomas
  • Meningiomas
  • Xanthogranuloma

Differential Diagnoses