Overview
What is tumor lysis syndrome (TLS)?
When does tumor lysis syndrome (TLS) arise?
Which tumors are associated with tumor lysis syndrome (TLS)?
What is the approach to management of tumor lysis syndrome (TLS)?
What is the pathophysiology of tumor lysis syndrome (TLS)?
What is the pathogenesis of hyperuricemia in tumor lysis syndrome (TLS)?
What is the pathogenesis of acute kidney injury (AKI) in tumor lysis syndrome (TLS)?
What causes tumor lysis syndrome (TLS)?
Which patients are at the highest risk for tumor lysis syndrome (TLS)?
What is the classification of cancers for the risk of tumor lysis syndrome (TLS)?
Which agents may cause tumor lysis syndrome (TLS)?
Which clinical conditions are rare causes of tumor lysis syndrome (TLS)?
What is the global incidence of tumor lysis syndrome (TLS)?
How does the incidence of tumor lysis syndrome (TLS) vary by age?
How is tumor lysis syndrome (TLS) prevented?
What are potential complications of tumor lysis syndrome (TLS)?
What causes cardiac arrhythmia and seizures in tumor lysis syndrome (TLS)?
What iatrogenic complications may occur with tumor lysis syndrome (TLS)?
What is the prognosis of acute kidney injury (AKI) in tumor lysis syndrome (TLS)?
What is the prognosis of cardiac arrhythmia in tumor lysis syndrome (TLS)?
What is the prognosis of metabolic acidosis in tumor lysis syndrome (TLS)?
Presentation
What should be the focus of clinical history in the evaluation of tumor lysis syndrome (TLS)?
What are manifestations of tumor lysis syndrome?
What are symptoms of hyperkalemia in tumor lysis syndrome (TLS)?
What are the signs and symptoms of severe hypocalcemia in tumor lysis syndrome (TLS)?
What are the signs and symptoms of calcium phosphate deposition in tumor lysis syndrome (TLS)?
What are the signs and symptoms of uremia relative to in tumor lysis syndrome (TLS)?
DDX
What are diagnostic considerations for tumor lysis syndrome (TLS)?
What are the differential diagnoses for Tumor Lysis Syndrome?
Workup
How can patients at risk for tumor lysis syndrome be identified?
What is the role of urine pH and output monitoring in the evaluation of tumor lysis syndrome (TLS)?
What is the role of imaging studies in the workup of tumor lysis syndrome (TLS)?
What is the role of cardiac monitoring in the workup of tumor lysis syndrome (TLS)?
Which histologic findings are characteristic of tumor lysis syndrome (TLS)?
What is the role of blood chemistry in the workup of tumor lysis syndrome (TLS)?
Treatment
How is tumor lysis syndrome (TLS) managed?
What is the role of dietary restrictions in the management of tumor lysis syndrome?
What consultations are recommended for the treatment of tumor lysis syndrome (TLS)?
What is included in surveillance for the prevention of tumor lysis syndrome (SLS)?
What should be monitored on a daily basis in patients with tumor lysis syndrome (TLS)?
What is the role of allopurinol in the management of tumor lysis syndrome (TLS)?
What is the role of febuxostat (Uloric) in the management of tumor lysis syndrome (TLS)?
How is hydration maintained in the prevention of tumor lysis syndrome (TLS)?
What is the role of diuresis for the treatment of tumor lysis syndrome?
What is the role of alkaline therapy in the treatment of tumor lysis syndrome (TLS)?
How is hyperkalemia managed in tumor lysis syndrome (TLS)?
How are hyperphosphatemia and hypocalcemia managed in tumor lysis syndrome (TLS)?
What is the role of dialysis in the treatment of tumor lysis syndrome (TLS)?
Medications
How are medications used in the management of tumor lysis syndrome (TLS)?
Which medications are used in the treatment of tumor lysis syndrome (TLS)?
Which medications in the drug class Electrolytes are used in the treatment of Tumor Lysis Syndrome?