Papillary Thyroid Carcinoma Medication

Updated: Feb 06, 2018
  • Author: Ponnandai S Somasundar, MD, MPH, FACS; Chief Editor: Neetu Radhakrishnan, MD  more...
  • Print
Medication

Medication Summary

The most useful drugs for the treatment of papillary thyroid carcinomas (a relatively common well-differentiated thyroid cancer) after surgery are levothyroxine and radioiodine.For metastases, palliation with antineoplastic agents (eg, doxorubicin) may be useful.

Next:

Thyroid products

Class Summary

These drugs are useful to prevent hypothyroidism and to stop TSH stimulation.

Levothyroxine (Synthroid)

In active form, influences growth and maturation of tissues. Involved in normal growth, metabolism, and development.

Previous
Next:

Antithyroid agents

Class Summary

These agents reduce serum thyroid hormone levels.

Sodium iodide I 131 (Iodotope)

Radioiodine is taken up by thyroid tissue and cannot be used in metabolic pathways. Emits beta and gamma radiation that causes destruction of thyroid tissue along a diameter of 400-2000 µm. Results in destruction of all residual thyroid tissues, either pathologic or normal.

Previous
Next:

Antineoplastic agents

Class Summary

These medications inhibit cell growth and proliferation and may be helpful in palliating symptoms in metastatic disease.

Cisplatin (Platinol)

Inhibits DNA synthesis and, thus, cell proliferation by causing DNA crosslinks and denaturation of double helix. Dose is related to body surface area.

Doxorubicin (Adriamycin)

Inhibits topoisomerase II and produces free radicals, which may cause destruction of DNA. Combination of these 2 events, in turn, can inhibit growth of neoplastic cells.

Previous
Next: