Carcinoma of the Ampulla of Vater Medication

Updated: May 08, 2018
  • Author: Nafisa K Kuwajerwala, MD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Medication Summary

Prophylactic and postoperative antibiotics are given according to hospital protocol.


Chemotherapeutic Agents

Class Summary

Fluorouracil can be used as a radiosensitizer for high-risk tumors of the ampulla of Vater.

Fluorouracil (Adrucil)

Fluorinated pyrimidine antimetabolite that inhibits thymidylate synthase and interferes with RNA synthesis and function. Has some effect on DNA. Useful in symptom palliation for patients with progressive disease.



Class Summary

Initial empiric antimicrobial therapy must be comprehensive and should cover both aerobic and anaerobic gram-negative organisms.

Cefoxitin (Mefoxin)

Second-generation cephalosporin indicated for gram-positive cocci and gram-negative rod infections. Infections caused by cephalosporin- or penicillin-resistant gram-negative bacteria may respond to cefoxitin.

Any second-generation cephalosporin may be used instead of cefoxitin.