Glioblastoma Multiforme Questions & Answers

Updated: Jul 28, 2021
  • Author: Jeffrey N Bruce, MD; Chief Editor: Herbert H Engelhard, III, MD, PhD, FACS, FAANS  more...
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Questions & Answers

Overview

What is glioblastoma multiforme (GBM)?

What are common symptoms of glioblastoma multiforme (GBM)?

What are the neurologic signs and symptoms of glioblastoma multiforme (GBM)?

What causes glioblastoma multiforme (GBM)?

How is glioblastoma multiforme (GBM) diagnosed?

How is glioblastoma multiforme (GBM) treated?

What are surgical options for the treatment of glioblastoma multiforme (GBM)?

What is the role of radiotherapy in the treatment of glioblastoma multiforme (GBM)?

What is the efficacy of chemotherapy for the treatment of glioblastoma multiforme (GBM)?

Which medications are used in the treatment of glioblastoma multiforme (GBM)?

What is glioblastoma multiforme (GBM)?

What is the pathophysiology of glioblastoma multiforme (GBM)?

What is the role of genetics in the pathophysiology of glioblastoma multiforme (GBM)?

Which genetic tumor markers have been used to classify glioblastoma multiforme (GBM)?

Which genetic abnormalities result in more malignant glioblastomas?

Which genetic alterations are associated with primary glioblastomas?

What is the pathophysiology of glioblastoma multiforme (GBM) in cerebral hemispheres?

What is the etiology of glioblastoma multiforme (GBM)?

What is the prevalence of glioblastoma multiforme (GBM)?

What is the prognosis of glioblastoma multiforme (GBM)?

What is included in patient education about glioblastoma multiforme (GBM)?

Presentation

Which clinical history findings are characteristic of glioblastoma multiforme (GBM)?

What are physical findings characteristic of glioblastoma multiforme (GBM)?

DDX

Which conditions should be considered in the differential diagnosis of glioblastoma multiforme (GBM)?

Workup

What is the role of lab studies in the workup of glioblastoma multiforme (GBM)?

What is the role of imaging studies in the diagnosis of glioblastoma multiforme (GBM)?

What is the role of MRI in the diagnosis of glioblastoma multiforme (GBM)?

What is the role of positron emission tomography (PET) scans and magnetic resonance (MR) spectroscopy in the diagnosis of glioblastoma multiforme (GBM)?

What is the role of EEG in the workup of glioblastoma multiforme (GBM)?

What is the role of lumbar puncture and CSF studies in the workup of glioblastoma multiforme (GBM)?

Which histologic findings are characteristic of glioblastoma multiforme (GBM)?

How is glioblastoma multiforme (GBM) staged?

Treatment

What are the treatment options for glioblastoma multiforme (GBM)?

What is included in standard treatment of glioblastoma multiforme (GBM)?

What is the role of temozolomide in the treatment of glioblastoma multiforme (GBM)?

What are the goals for surgery in glioblastoma multiforme (GBM)?

Which factors have prognostic significance in glioblastoma multiforme (GBM)?

What are survival rates for surgery for glioblastoma multiforme (GBM)?

What aids are used to visualize glioblastoma multiforme (GBM) during surgery?

What are the AANS/CNS clinical practice guidelines for use of cytotoxic chemotherapy in the treatment of glioblastoma multiforme (GBM)?

What is standard-of-care therapy for the treatment of glioblastoma multiforme (GBM)?

What is the role of radiation therapy in the treatment of glioblastoma multiforme (GBM)?

What is the role of interstitial brachytherapy in the treatment of glioblastoma multiforme (GBM)?

Which radiation therapies for glioblastoma multiforme (GBM) are under investigation?

What is the efficacy of radiotherapy for the treatment of recurrent glioblastoma multiforme (GBM)?

What are the benfits of concomitant threatment with bevacizumab for patients undergoing re-irradiation for recurrent glioblastoma?

What is the role of antineoplastic chemotherapy in the treatment of glioblastoma multiforme (GBM)?

What are the preferred chemotherapy agents for the treatment of glioblastoma multiforme (GBM)?

What is the role of carmustine-polymer wafers (Gliadel) in the treatment of recurrent glioblastoma multiforme (GBM)?

What is the role of bevacizumab the treatment of glioblastoma multiforme (GBM)?

What is the role of electric-field therapy for the treatment of glioblastoma multiforme (GBM)?

Which complications of glioblastoma multiforme (GBM) may require supportive care?

How is vasogenic edema managed in patients with glioblastoma multiforme (GBM)?

How are seizures managed in patients with glioblastoma multiforme (GBM)?

How is VTE managed in patients with glioblastoma multiforme (GBM)?

Which specialist consultations are needed for the treatment of glioblastoma multiforme (GBM)?

Which therapeutic approaches are under investigation for the treatment of glioblastoma multiforme (GBM)?

What is the role of vaccine therapy in the treatment of glioblastoma multiforme (GBM)?

What is the role of tyrosine kinase inhibitors in the treatment of glioblastoma multiforme (GBM)?

What is the role of checkpoint inhibitor therapy in the treatment of glioblastoma multiforme (GBM)?

What is the role of convection-enhanced delivery (CED) in the treatment of glioblastoma multiforme (GBM)?

Which activity modifications are used in the treatment of glioblastoma multiforme (GBM)?

Guidelines

What are the NCCN guidelines on diagnosis and treatment of glioblastoma multiforme (GBM)?

What are the EANO guidelines for the palliative care of patients with glioblastoma multiforme (GBM)?

Medications

Which medications are used in the treatment of glioblastoma multiforme (GBM)?

Which medications in the drug class Corticosteroids are used in the treatment of Glioblastoma Multiforme?

Which medications in the drug class Anticonvulsants are used in the treatment of Glioblastoma Multiforme?

Which medications in the drug class Antineoplastic agents are used in the treatment of Glioblastoma Multiforme?