Posttraumatic Stress Disorder Differential Diagnoses

1. American Psychiatric Association. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Arlington, VA: 2013.

2. National Institute of Mental Health. Helping Children and Adolescents Cope with Violence and Disasters. NIH Publication No. 01-3518. Bethesda, Md:. National Institute of Mental Health; 2001. [Full Text].

3. Rothbaum, B. O., Price, M., Jovanovic, T., et al. A randomized, double-blind evaluation of d-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War Veterans. American Journal of Psychiatry, 171, 640-648. American Journal of Psychiatry. 2014. 171:640-648.

4. Goldstein S & Brooks R. Handbook of Resilience in Children. Springer.; 2013.

5. McLaughlin, K, Fairbank, J, Gruber, M. Trends in Serious Emotional Disturbance among Youths Exposed to Hurricane Katrina. J of the Am Academy of Child Adolesc Psychiatry. 2010. 49(10):990-1000.

6. Carr CP1, Martins CM, Stingel AM, Lemgruber VB, Juruena MF. The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis. 2013. 201(12):1007-20.

7. Kasai K, Yamasue H, Gilbertson MW, Shenton ME, Rauch SL, Pitman RK. Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biol Psychiatry. 2008 Mar 15. 63(6):550-6. [QxMD MEDLINE Link]. [Full Text].

8. LISA M. SHIN,SCOTT L. RAUCH,ROGER K. PITMAN. Amygdala, Medial Prefrontal Cortex, and Hippocampal Function in PTSD. Annals of the NY Academy of Sciences. 2006.

9. Giacomo Ronzoni, Alberto del Arco1, Francisco Mora, Gregorio Segovia. nhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD. Psychoneuroendocrinology. 2016. 70:1-9.

10. Bremner JD, Elzinga B, Schmahl C, & Vermetten E. Structural and functional plasticity of the human brain in posttraumatic stress disorder. . Progress in brain research. 2008. 167:171-86.

11. Brewin CR, Dalgleish T and Joseph S. A dual representation theory of post-traumatic stress disorder. Psychological Review. 1996. 103:670-686.

12. Brewin, Chris; Holmes, Emily. Psychological theories of posttraumatic stress disorder. Clinical Psychology Review. 2003. 23:339–376.

13. Roth, S.; Newman, E.; Pelcovitz, D.; Van Der Kolk, B.; Mandel, F. S. Complex PTSD in victims exposed to sexual and physical abuse: Results from the DSM-IV Field Trial for Posttraumatic Stress Disorder". Journal of traumatic stress. Journal of traumatic stress. 1997. 10 (4):539–55.

14. Freyd J & P Birrell. Blind to Betrayal. Hoboken: Wiley.; 2013.

15. Freyd JJ, Klest B, Allard CB. Betrayal trauma: relationship to physical health, psychological distress, and a written disclosure intervention. J Trauma Dissociation. 2005. 6(3):.:83-104.

16. Olsson KA, Kenardy JA, De Young AC, Spence SH. Predicting children's post-traumatic stress symptoms following hospitalization for accidental injury: combining the Child Trauma Screening Questionnaire and heart rate. J Anxiety Disord. 2008 Dec. 22(8):1447-53. [QxMD MEDLINE Link].

17. Sonne SC, Back SE, Diaz Zuniga C, Randall CL, Brady KT. Gender differences in individuals with comorbid alcohol dependence and post-traumatic stress disorder. Am J Addict. 2003 Oct-Dec. 12(5):412-23. [QxMD MEDLINE Link].

18. Schwartz AC, Bradley R, Penza KM, Sexton M, Jay D, Haggard PJ, et al. Pain medication use among patients with posttraumatic stress disorder. Psychosomatics. 2006 Mar-Apr. 47(2):136-42. [QxMD MEDLINE Link]. [Full Text].

19. Brooks M. Heavy drinking, PTSD in college students linked. Medscape Medical News. January 23, 2014. [Full Text].

20. Read JP, Wardell JD, Colder CR. Reciprocal associations between PTSD symptoms and alcohol involvement in college: a three-year trait-state-error analysis. J Abnorm Psychol. 2013 Nov. 122(4):984-97. [QxMD MEDLINE Link].

21. Yaffe K, Vittinghoff E, Lindquist K, Barnes D, Covinsky KE, Neylan T, et al. Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry. 2010 Jun. 67(6):608-13. [QxMD MEDLINE Link]. [Full Text].

22. Rodriguez BF, Weisberg RB, Pagano ME, Machan JT, Culpepper L, Keller MB. Mental health treatment received by primary care patients with posttraumatic stress disorder. J Clin Psychiatry. 2003 Oct. 64(10):1230-6. [QxMD MEDLINE Link].

23. Connor KM, Davidson JR. Further psychometric assessment of the TOP-8: a brief interview-based measure of PTSD. Depress Anxiety. 1999. 9(3):135-7. [QxMD MEDLINE Link].

24. Hamilton A. Diagnosis and rating of anxiety. Special Publication: Br J Psychiatry; 1969. 3:76-79.

25. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967 Dec. 6(4):278-96. [QxMD MEDLINE Link].

26. Brunet A, Saumier D, Liu A, Streiner DL, Tremblay J, Pitman RK. Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial. Am J Psychiatry. 2018 Jan 12. appiajp201717050481. [QxMD MEDLINE Link].

27. Hogberg G, Pagani M, Sundin O, Soares J, Aberg-Wistedt A, Tarnell B, et al. Treatment of post-traumatic stress disorder with eye movement desensitization and reprocessing: outcome is stable in 35-month follow-up. Psychiatry Res. 2008 May 30. 159(1-2):101-8. [QxMD MEDLINE Link].

28. Ponniah K, Hollon SD. Empirically supported psychological treatments for adult acute stress disorder and posttraumatic stress disorder: a review. Depress Anxiety. 2009. 26(12):1086-109. [QxMD MEDLINE Link].

29. Bronson D, Franco K, Budur K. Posttraumatic stress disorder in primary care patients. Compr Ther. 2007 Winter. 33(4):208-15. [QxMD MEDLINE Link].

30. Nijdam MJ, Gersons BP, Reitsma JB, de Jongh A, Olff M. Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: randomised controlled trial. Br J Psychiatry. 2012 Mar. 200(3):224-31. [QxMD MEDLINE Link].

31. Harrison P. Evidence Supports Psychological Therapies for PTSD Kids. Medscape Medical News. December 11, 2012. [Full Text].

32. Gillies D, Taylor F, Gray C, O'Brien L, D'Abrew N. Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents. Cochrane Database Syst Rev. 2012 Dec 12. 12:CD006726. [QxMD MEDLINE Link].

33. Davis LL, Frazier EC, Williford RB, Newell JM. Long-term pharmacotherapy for post-traumatic stress disorder. CNS Drugs. 2006. 20(6):465-76. [QxMD MEDLINE Link].

34. Bisson JI, Ehlers A, Matthews R, Pilling S, Richards D, Turner S. Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis. Br J Psychiatry. 2007 Feb. 190:97-104. [QxMD MEDLINE Link].

35. Germain A, Shear MK, Hall M, Buysse DJ. Effects of a brief behavioral treatment for PTSD-related sleep disturbances: a pilot study. Behav Res Ther. 2007 Mar. 45(3):627-32. [QxMD MEDLINE Link].

36. Raskind MA, Peskind ER, Hoff DJ, Hart KL, Holmes HA, Warren D, et al. A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007 Apr 15. 61(8):928-34. [QxMD MEDLINE Link].

37. Brooks M. New WHO Guideline on Mental Health Care After Trauma. Medscape Medical News. Available at http://www.medscape.com/viewarticle/809185. Accessed: August 14, 2013.

38. Tol WA, Barbui C, van Ommeren M. Management of acute stress, PTSD, and bereavement: WHO recommendations. JAMA. 2013 Aug 7. 310(5):477-8. [QxMD MEDLINE Link].

39. Litz BT, Engel CC, Bryant RA, Papa A. A randomized, controlled proof-of-concept trial of an Internet-based, therapist-assisted self-management treatment for posttraumatic stress disorder. Am J Psychiatry. 2007 Nov. 164(11):1676-83. [QxMD MEDLINE Link].

40. Shalev AY, Ankri Y, Gilad M,. Long-Term Outcome of Early Interventions to Prevent Posttraumatic Stress Disorder. J Clin Psychiatry. 2016. 77(5):580-587.

41. Ot'alora G M, Grigsby J, Poulter B, Van Derveer JW 3rd, Giron SG, Jerome L, et al. 3,4-Methylenedioxymethamphetamine-assisted psychotherapy for treatment of chronic posttraumatic stress disorder: A randomized phase 2 controlled trial. J Psychopharmacol. 2018 Oct 29. 269881118806297. [QxMD MEDLINE Link].

42. Bisson, J. Post Traumatic Stress Disorder. Occupational Medicine. 2007. 57 Issue 6:399-403.

43. Matthew J. Friedman MD PhD. Handbook of PTSD. 2. Guilford; 2014.

44. Hoskins, M., Pearce, J., Bethell, A., et al. Pharmacotherapy for post-traumatic stress disorder: Systematic review and meta-analysis. The. British Journal of Psychiatry : The Journal of Mental Science,. 2015. 206 (2):93-100.

45. Haagen, JF; Smid, GE; Knipscheer, JW; Kleber, RJ. "The efficacy of recommended treatments for veterans with PTSD: A metaregression analysis.". Clinical Psychology Review. 2015. 40:184–94.

46. Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Johnes, KM, et al. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD. JAMA. Aug 2011. 306(5):461-568.

47. Davenport L. Add-on Antipsychotic Promising for PTSD, Anxiety. Medscape Medical News. Available at https://www.medscape.com/viewarticle/893386. March 5, 2018; Accessed: March 7, 2018.

48. Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK. Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2008 May. 42(6):503-6. [QxMD MEDLINE Link].

49. Hoge CW, Auchterlonie JL, Milliken CS. Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan. JAMA. 2006 Mar 1. 295(9):1023-32. [QxMD MEDLINE Link].

50. Hoge CW, Castro CA, Messer SC, McGurk D, Cotting DI, Koffman RL. Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. N Engl J Med. 2004 Jul 1. 351(1):13-22. [QxMD MEDLINE Link].

51. Turner JH, Neylan TC, Schiller NB, Li Y, Cohen BE. Objective evidence of myocardial ischemia in patients with posttraumatic stress disorder. Biol Psychiatry. 2013 Dec 1. 74(11):861-6. [QxMD MEDLINE Link].

52. Vaccarino V, Bremner JD. Traumatic stress is heartbreaking. Biol Psychiatry. 2013 Dec 1. 74(11):790-2. [QxMD MEDLINE Link].

53. Cassels C. PTSD Independently Linked to Ischemic Heart Disease. Medscape [serial online]. Available at http://www.medscape.com/viewarticle/814375. Accessed: December 2, 2013.

T Allen Gore, MD, MBA, CMCM, DFAPA Volunteer Associate Professor, Department of Psychiatry, Howard University School of Medicine; Senior Psychiatrist and Director, Medical Education, Comprehensive Psychiatric Emergency Program, District of Columbia Department of Mental Health

T Allen Gore, MD, MBA, CMCM, DFAPA is a member of the following medical societies: American Psychiatric Association, National Association of Managed Care Physicians, National Medical Association

Disclosure: Nothing to disclose.

Joel Z Lucas, MD Senior Medical Writer, Reckitt Benckiser Pharmaceuticals, Inc

Joel Z Lucas, MD is a member of the following medical societies: American College of Physicians, American Medical Student Association/Foundation, Student National Medical Association

Disclosure: Received salary from Johnson & Johnson for employment.

Roy H Lubit, MD, PhD Private Practice

Roy H Lubit, MD, PhD is a member of the following medical societies: American Academy of Child and Adolescent Psychiatry

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

David Bienenfeld, MD Professor, Departments of Psychiatry and Geriatric Medicine, Wright State University, Boonshoft School of Medicine

David Bienenfeld, MD is a member of the following medical societies: American Medical Association, American Psychiatric Association, Association for Academic Psychiatry

Disclosure: Nothing to disclose.

The authors would like to thank all colleagues and students who contributed to this article. We are especially grateful to the following individuals:

Georgianna M Richards-Reid, MD, Staff Physician, Department of Neurology, Howard University Hospital, Howard University College of Medicine

Zachary Osborne, MD; Ross University School of Medicine

Bobbi Adams, BS; University of Alabama

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