Wernicke-Korsakoff Syndrome Questions & Answers

Updated: May 16, 2018
  • Author: Glen L Xiong, MD; Chief Editor: David Bienenfeld, MD  more...
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Questions & Answers

Overview

What is Wernicke-Korsakoff Syndrome (WKS)?

What causes the symptom complex of Wernicke-Korsakoff Syndrome (WKS)?

What causes Wernicke-Korsakoff Syndrome (WKS)?

What role does thiamine have in the pathophysiology of Wernicke-Korsakoff Syndrome (WKS)?

What is the pathophysiology of Wernicke-Korsakoff syndrome (WKS)?

What is the role of norepinephrine (3-methoxy-4-hydroxyphenolglycol, or MHPG) in the pathophysiology of Wernicke-Korsakoff syndrome (WKS)?

What is the role of genetics in the pathophysiology of Wernicke-Korsakoff syndrome (WKS)?

What is the prevalence of Wernicke-Korsakoff syndrome (WKS) in the US?

What is the global prevalence of Wernicke-Korsakoff syndrome (WKS)?

Which patient groups are at highest risk for Wernicke-Korsakoff syndrome (WKS)?

What is the prognosis of Wernicke-Korsakoff syndrome (WKS)?

What are ocular complications of Wernicke-Korsakoff syndrome (WKS)?

What are ataxic complications of Wernicke-Korsakoff syndrome (WKS)?

What are psychiatric complications of Wernicke-Korsakoff syndrome (WKS)?

What is the mortality of Wernicke-Korsakoff syndrome (WKS)?

How should patients be educated about Wernicke-Korsakoff syndrome (WKS)?

Presentation

What are the signs and symptoms of Wernicke-Korsakoff syndrome (WKS)?

What history findings suggest Wernicke-Korsakoff syndrome?

Which ocular abnormalities are characteristic of Wernicke-Korsakoff syndrome (WKS) on physical exam?

How is ataxia characterized in Wernicke-Korsakoff syndrome (WKS)?

Which mental status changes are characteristic of Wernicke-Korsakoff syndrome (WKS)?

When are stupor or coma typically observed in patients with Wernicke-Korsakoff syndrome (WKS)?

What is the amnestic state of Wernicke-Korsakoff syndrome (WKS)?

How is the Korsakoff amnestic state characterized?

What are cardiovascular manifestations of Wernicke-Korsakoff syndrome (WKS)?

DDX

How is Wernicke-Korsakoff syndrome (WKS) diagnosed?

What is the sensitivity and specificity of the Caine diagnostic criteria for Wernicke-Korsakoff syndrome (WKS)?

What are the British Royal College of Physicians guidelines for Wernicke-Korsakoff syndrome (WKS)?

What are the differential diagnoses of Korsakoff psychosis?

What are the differential diagnoses for Wernicke-Korsakoff Syndrome?

Workup

What should be included in the evaluation of Wernicke-Korsakoff syndrome (WKS)?

What is the role of lab tests in the evaluation of Wernicke-Korsakoff syndrome (WKS)?

What is the role of serum thiamine measurement in the evaluation of Wernicke-Korsakoff syndrome (WKS)?

What is the role of lumbar puncture and CSF analysis in the evaluation of Wernicke-Korsakoff syndrome (WKS)?

What is the role of imaging studies in the evaluation of Wernicke-Korsakoff syndrome (WKS)?

Treatment

What is the initial approach to treatment for Wernicke-Korsakoff syndrome (WKS)?

Which medications are used in the treatment of Wernicke-Korsakoff syndrome (WKS)?

What is the role of parental thiamine in the treatment of Wernicke-Korsakoff syndrome (WKS)?

What are adverse reactions to thiamine for the treatment of Wernicke-Korsakoff syndrome (WKS)?

What is the role of IV glucose in the treatment of Wernicke-Korsakoff syndrome (WKS)?

When is inpatient treatment indicated in the treatment of Wernicke-Korsakoff syndrome (WKS)?

What is the role of nutritional supplementation in the treatment of Wernicke-Korsakoff syndrome (WKS)?

What is included in inpatient care for Wernicke-Korsakoff syndrome (WKS)?

What diet and activity modifications are needed during the treatment of Wernicke-Korsakoff syndrome (WKS)?

What is included in long-term monitoring of patients with Wernicke-Korsakoff syndrome (WKS)?

How is Wernicke-Korsakoff syndrome (WKS) prevented?

When is neuropsychological testing and rehabilitation indicated in the management of Wernicke-Korsakoff syndrome (WKS)?

Medications

What are the medication recommendations for the treatment of Wernicke-Korsakoff syndrome (WKS)?

Which medications in the drug class Nutrients are used in the treatment of Wernicke-Korsakoff Syndrome?