Brief psychotic disorder is currently classified with schizophrenia spectrum and other psychotic disorders. It is differentiated from other related disorders by its sudden onset, its relatively short duration (< 1 month), and the full return of functioning.
Sudden onset is defined as change from non-psychotic state to a clearly psychotic state within 2 weeks, usually without prodrome.
Brief psychotic disorder is characterized by the abrupt onset of 1 or more of the following symptoms:
Delusions
Hallucinations
Bizarre behavior and posture
Disorganized speech
Associated symptoms may include the following:
Affective symptoms
Disorientation
Impaired attention
Catatonic behavior
The following are also commonly observed in brief psychotic disorder:
Emotional volatility
Outlandish dress or behavior
Screaming or muteness
Impaired memory for recent events
A psychiatric history may be helpful.
Symptoms of brief psychotic disorder must be distinguished from culturally sanctioned response patterns that may resemble such symptoms. Cultural and religious background must always be taken into account when a judgment is to be made about whether a given patient’s beliefs are delusional.
Routine physical examination is necessary to exclude medical causes of psychosis. A careful Mental Status Examination is vital.
See Presentation for more detail.
Specific laboratory studies for brief psychotic disorder do not exist. The history, the physical examination, and laboratory tests can help differentiate this condition from psychotic disorder secondary to general medical condition, delirium, and various other disorders.
No imaging studies are required for diagnosis; though CT, MRI, and EEG may be considered for assessing possible medical causes of psychosis.
See Workup for more detail.
Management considerations include the following:
Treatment is brief and focused on being as nonrestrictive as possible
It is clinically imperative to prevent patients from harming themselves or others; thus, brief hospitalization may be necessary, potentially including brief seclusion or restraint for aggressive or combative patients
If symptoms are only minimally impairing the patient’s function and a specific stressor is identified, removing the stressor should suffice for treatment
If symptoms are disabling, an antipsychotic agent should be given, but for no longer than 1 month. Some of the commonly used antipsychotics include the following:
Haloperidol
Fluphenazine
Olanzapine
Quetiapine
Ziprasidone
Risperidone
Paliperidone
Once the acute attack has ended, further inpatient care is unnecessary. Individual, family, and group psychotherapy may be considered to help cope with stressors, resolve conflict, and improve self-esteem and self-confidence.
See Treatment and Medication for more detail.
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), classifies brief psychotic disorder as belonging to the category of schizophrenia spectrum and other psychotic disorders.[1] These disorders are characterized by delusions, hallucinations, disorganized thinking, motor behavior abnormalities (including catatonia), and negative symptoms.
Brief psychotic disorder is distinguished from related disorders by the combination of sudden onset, relatively short duration (< 1 month) and full return of functioning. The diagnosis has been better appreciated and more completely studied in Scandinavia and other Western European countries than it has been in the United States.
The specific DSM-5 criteria for brief psychotic disorder are as follows[1] :
The patient must have 1 or more of the following symptoms: delusions, hallucinations, disorganized speech (eg, frequent derailment or incoherence), and grossly disoriented or catatonic behavior; 1 or more of the first 3 symptoms must always be present; a symptom should not be included if it is a culturally sanctioned response
The duration of an episode of the disturbance is at least 1 day but less than 1 month, with eventual full return to premorbid level of functioning
The disturbance cannot be better explained by major depressive or bipolar disorder with psychotic features or by another psychotic disorder (eg, schizophrenia or catatonia), nor can it be attributed to the physiologic effects of a substance or medication or another medical condition
In addition, the following must be specified:
Presence of marked stressor(s) (brief reactive psychosis)
Absence of marked stressor(s)
Postpartum onset (if onset is during pregnancy or ≤4 weeks post partum)[2, 3]
Presence of catatonia
Use additional code 293.89 (F06.1) when catatonia is associated with brief psychotic disorder to indicate the presence of the comorbid catatonia.
The severity of brief psychotic disorder can be specified on the basis of quantitative assessment of the primary symptoms (see above), though a diagnosis can be made without specifying severity in this manner. Each symptom is rated with respect to current severity on a 5-point scale that ranges from 0 (not present) to 4 (present and severe).
The causes of brief psychotic episodes are largely unknown. Patients with personality disorder may have biologic or psychological vulnerability toward the development of psychotic symptoms. One or more severe stress factors, such as traumatic events, family conflict, employment problems, accidents, severe illness, death of a loved one, and uncertain immigration status, can precipitate brief reactive psychosis.
Psychodynamic theories suggest that the psychotic symptoms occur because of inadequate coping mechanisms, as a defense against prohibited fantasy, or as an escape from a specific psychological situation or an overwhelming stressful circumstance. It must be understood that the individual perceives the stress as totally overwhelming. Neither biologic nor psychological theories have been validated by carefully controlled clinical studies.
Some studies support a genetic vulnerability to brief psychotic disorder. Some data suggest an increased incidence of mood disorders in families of patients with brief psychotic disorder.
Brief psychotic disorder is not common. In a follow-up study of 221 first-admission patients with affective and nonaffective psychoses, only 20 (9%) of the 221 experienced brief psychoses, and only 7 (3%) experienced acute brief psychoses.[4]
According to an international epidemiologic study, the incidence of nonaffective acute remitting psychoses in contrast to that of schizophrenia, was 10-fold higher in developing countries than in industrialized countries.[5] Some clinicians believe that the disorder may occur most frequently in patients from lower socioeconomic classes, patients with preexisting personality disorders, and immigrants.
In nonindustrialized countries, such terms as yak, latah, koro, amok, and whitiligo have been used to describe psychotic states precipitated by stressful events. These and several similar cultural terms are now considered to be culture-bound syndromes.
Although this disorder may appear in adolescence or early adulthood it can occur accross the life span. The disorder is more common in patients late in the third to early in the fourth decade of life. Cases have also been recognized later in life. An international epidemiologic study found the incidence of the disorder to 2-fold higher in women than in men.[5] Study reports from the United States indicate an even preponderance in women.
Generally, brief psychotic disorder has a good prognosis and runs its course in less than 1 month. A good prognosis is usually associated with sudden onset, short duration of symptoms, and good premorbid adjustment; the prognosis is especially favorable for patients with no premorbid psychiatric history. According to European studies, 50-80% of all patients have no further major psychiatric problems.
As with any other psychotic episode, the risk of harm to self or others increases with an acute episode of brief psychotic disorder.[6] Some data indicate that a brief psychotic episode with an acute onset may be an early manifestation of severe mental disorder (eg, an affective disorder).[7] Patients may be at risk for committing suicide during psychotic episodes, especially when brief psychotic disorder is associated with affective symptoms.
Both the patient and the family must be educated about the illness and the potential adverse effects of the medications. Helpful Web sites include the following:
MedlinePlus, Brief reactive psychosis
WebMD, Schizophrenia and Brief Psychotic Disorder
MedicineNet.com, Brief Psychotic Disorder
Brief psychotic disorder is characterized by the abrupt onset of 1 or more of the following symptoms:
Delusions - Rapidly changing delusional topics
Hallucinations
Bizarre behavior and posture
Disorganized speech
Patients may present with a variety of associated symptoms, including the following:
Affective symptoms - Rapidly changing mood
Disorientation - A careful Mental Status Examination can distinguish this from delirium, dementia, or other organic brain syndromes
Impaired attention
Catatonic behavior (in some cases)
The following are also commonly observed in brief psychotic disorder:
Emotional volatility
Outlandish dress or behavior
Screaming or muteness
Impaired memory for recent events
A psychiatric history may be helpful. Some clinicians believe that persons with personality disorders (eg, narcissistic, paranoid, borderline, schizotypal) are more prone to develop brief psychotic disorder in stressful situations.[8]
DSM-5 stresses that symptoms of brief psychotic disorder must be distinguished from culturally sanctioned response patterns that may resemble such symptoms.[1] For instance, hearing voices may be a component of some religious ceremonies; this generally would not be considered abnormal by most members of the religious community, and the voices typically would not persist into daily life. Cultural and religious background must always be taken into account when a judgment is to be made about whether a given patient’s beliefs are delusional.
Routine physical examination is necessary to exclude medical causes of psychosis. A careful Mental Status Examination is vital. Patients usually present with severe psychotic agitation that may be associated with the following:
Strange or bizarre behavior
Uncooperativeness
Physical or verbal aggression
Disorganized speech
Screaming or muteness
Labile or depressed mood
Suicidal or homicidal thoughts or behaviors
Restlessness
Hallucinations
Delusions
Disorientation
Impaired attention, concentration, or memory
Poor insight or judgment
Psychological stressors in individuals with personality disorders may precipitate brief periods of psychotic symptoms. In such cases, if symptoms persist longer than 1 day, an additional diagnosis of brief psychotic disorder may be considered.
In addition to the conditions listed in the differential diagnosis, other problems to be considered include the following:
Substance-induced psychotic disorder
Mood disorders like major depression and bipolar disorder with psychotic features
Unspecified schizophrenia spectrum and other psychotic disorder like schizophrenia, schizophreniform disoder, and delusional disorder
Psychosis associated with personality disorders
Other medical conditions, for example, delirium, seizure disorder, cushings syndrome, brain tumors, etc.
Malingering and factitious disoders
The history, the physical examination, and laboratory tests can help differentiate brief psychotic disorder from psychotic disorder secondary to general medical condition, delirium, and various other disorders. (See Presentation and Workup.)
The occurrence of a psychotic episode during a full affective episode excludes the diagnosis of brief psychotic disorder. If psychotic symptoms persist for longer than 1 month, schizophreniform disorder, schizoaffective disorder, schizophrenia, delusional disorder, mood disorder with psychotic features, or unspecified psychotic disorders are the most important possibilities to be considered. Rapidly changing delusions and rapidly changing mood also help differentiate brief psychotic disorder from schizophrenia, schizoaffective disorder, and delusional disorder.
In the case of malingering, there is usually some evidence indicating that the illness was feigned for an understandable goal. In factitious disorder, the history may reveal that the symptoms were intentionally produced. The presence of a florid psychosis makes the diagnosis of dissociative disorder unlikely.
Psychological stressors in individuals with personality disorders may precipitate brief periods of psychotic symptoms. In such cases, if symptoms persist for longer than 1 day, an additional diagnosis of brief psychotic disorder may be considered.
Schizophreniform Disorder
Specific laboratory studies for brief psychotic disorder do not exist. Comprehensive neuropsychiatric assessment, physical examination, and laboratory tests can help differentiate brief psychotic disorder from psychotic disorder secondary to general medical condition, delirium, and various other disorders. Routine and specific laboratory work may be needed to exclude other causes of psychoses.
Substance-induced psychotic disorder, substance-induced delirium, and substance intoxication can be distinguished from brief psychotic disorder by considering onset, course, urine drug screening, and blood alcohol levels.
No imaging studies are required to diagnose brief psychotic disorder. Further testing with modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and electroencephalography (EEG) may be considered, but such studies are useful only for diagnosing possible medical causes of the psychosis.
It is important to evaluate weight, metabolic state, cardiac, sexual and neurologic functions along with hematologic health as well as periodic monitoring for changes in these areas during the treatment is recomended.[9]
Because of the short duration of brief psychotic disorder, treatment is brief and focused on being as nonrestrictive as possible. However, it remains clinically imperative to prevent patients from harming themselves or others. Accordingly, patients experiencing an acute psychotic attack may have to be hospitalized briefly so that they can be evaluated and their safety ensured. If a patient becomes aggressive and combative, brief seclusion or restraint may be necessary.
If symptoms are only minimally impairing the patient’s function and a specific stressor is identified, removing the stressor should suffice for treatment of the brief psychotic episode.
If, however, symptoms are disabling, an antipsychotic agent should be given, but for no longer than 1 month. Commonly used typical (first-generation) antipsychotics include the following:
If adverse effects are intolerable, it may be helpful to use one of the atypical (second-generation) antipsychotics, for example:
At present, the available evidence is not sufficient to support the use of atypical antipsychotics to treat brief psychotic disorder. A case series suggests that rapid tranquilization with olanzapine can achieve symptom relief in acute psychosis.[10] A study involving intramuscular (IM) ziprasidone showed this agent to be more effective and better tolerated than IM haloperidol for treating acute psychosis.[11] In the authors’ experience, IM ziprasidone is the most effective treatment for acute severe psychotic agitation.
Once the acute attack has ended, further inpatient care is unnecessary. Individual, family, and group psychotherapy may be considered to help cope with stressors, resolve conflict, and improve self-esteem and self-confidence.
The goals of pharmacotherapy are to reduce morbidity and to prevent complications. Both typical and atypical antipsychotic agents have been used in the treatment of brief psychotic disorder.
Antipsychotics are high-potency agents that provide rapid, predictable, and effective sedation in the management of patients who are acutely psychotic. They are less sedating and more easily titrated than lower-potency agents but more likely to cause extrapyramidal syndrome (EPS). They are often combined in the same syringe with a benzodiazepine to improve sedation and anxiety and reduce dystonia or akathisia. For prophylaxis of EPS, temporary use of a serotonin-dopamine antagonist may be needed.
Antipsychotics may be administered intramuscularly (IM) or intravenously (IV). In a nonemergency setting, haloperidol may be given orally. Haloperidol also has a monthly depot form (haloperidol decanoate), but this is not useful for brief psychotic disorder, because of the short duration of the psychotic episode.
Haloperidol controls psychosis and provides rapid tranquilization. It can be administered with a benzodiazepine to protect against a lowered seizure threshold. IV haloperidol can be used effectively to treat acute psychotic agitation in a low dosage of 1-2 mg every 8 hours for 2-3 days, and the drug can be continued orally for the next several days until symptoms completely subside. In cases where it is difficulty to differentiate brief psychotic disorder and delirium, it should be kept in mind that IV haloperidol is also effective for delirium.
Thiothixene blocks postsynaptic blockade of central nervous system (CNS) dopamine receptors, inhibiting dopamine-mediated effects. It provides rapid tranquilization in both oral and IM forms.
Unlike haloperidol, risperidone has serotonergic blocking effects that alleviate negative symptoms of psychosis (eg, anhedonia, avolition, amotivation, and flat affect). It is well tolerated and has fewer extrapyramidal adverse effects than typical antipsychotics do. Dosages higher than 6 mg/day increase the risk of extrapyramidal effects.
Olanzapine may inhibit serotonin, muscarinic, and dopamine effects. Its efficacy is similar to that of risperidone; it has fewer dose-dependent adverse effects but is more likely to be associated with weight gain.
Quetiapine may act by antagonizing dopamine and serotonin effects. Its efficacy is similar to those of risperidone and olanzapine; it has fewer dose-dependent adverse effects and poses less of a concern with regard to weight gain.
Paliperidone is the major active metabolite of risperidone and the first oral agent that can be given once daily. It is indicated for treatment of acute schizophrenia. The mechanism of action is not completely understood but is thought to involve mediation of central receptor antagonism of dopamine type 2 (D2) and serotonin type 2 (5-HT2A). It also elicits antagonist activity at alpha1- and alpha2-adrenergic receptors and histamine-1 receptors. It has no affinity for cholinergic, muscarinic, or beta-adrenergic receptors.
Overview
How is brief psychotic disorder treated?
What is brief psychotic disorder?
What are the signs and symptoms of brief psychotic disorder?
How is brief psychotic disorder diagnosed?
How is brief psychotic disorder classified?
What are the DSM-5 diagnostic criteria for brief psychotic disorder?
What causes brief psychotic disorder?
What is the US prevalence of brief psychotic disorder?
What is the global prevalence of brief psychotic disorder?
Which patient groups have the highest prevalence of brief psychotic disorder?
What is the prognosis for brief psychotic disorder?
What is included in the patient education about brief psychotic disorder?
Presentation
Which clinical history findings are characteristic of brief psychotic disorder?
What is included in the evaluation for brief psychotic disorder?
DDX
Which conditions are included in the differential diagnoses of brief psychotic disorder?
How is brief psychotic disorder differentiated from other psychotic disorders?
What are the differential diagnoses for Brief Psychotic Disorder?
Workup
How is brief psychotic disorder diagnosed?
Treatment
How is brief psychotic disorder treated?
Medications
What is role of medications in the treatment of brief psychotic disorder?