Primary Ciliary Dyskinesia (Kartagener Syndrome) Medication

Updated: Jun 12, 2020
  • Author: Elena B Willis, MD; Chief Editor: John J Oppenheimer, MD  more...
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Medication

Medication Summary

Early intervention should be instituted with antibiotics directed at specific organisms identified by nasal secretions and/or expectorated sputum samples. Sensitivities of these samples should be obtained because resistant microorganisms can develop. Mucolytics may be helpful in specific individuals.

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Antibiotics

Class Summary

Antibiotics are used to treat acute or chronic infection or for prophylaxis against infection. Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Trimethoprim and sulfamethoxazole (Bactrim DS, Septra)

This combination inhibits bacterial growth by inhibiting the synthesis of dihydrofolic acid. The antibacterial activity of TMP-SMZ includes common urinary tract pathogens, except Pseudomonas aeruginosa. The dose depends on whether treatment is prophylactic or for ongoing infection.

Amoxicillin (Biomox, Trimox, Amoxil)

Amoxicillin interferes with the synthesis of cell wall mucopeptides during active multiplication, resulting in bactericidal activity against susceptible bacteria.

Amoxicillin and clavulanate (Augmentin)

This drug combination treats bacteria resistant to beta-lactam antibiotics. In children older than 3 months, base dosing protocol on amoxicillin content. Owing to the different amoxicillin/clavulanic acid ratios in the 250-mg tablet (250/125) versus the 250-mg chewable tablet (250/62.5), do not use the 250-mg tablet until the child weighs more than 40 kg.

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Expectorants

Class Summary

Expectorants may thin mucous secretions.

Guaifenesin (Humibid LA)

Guaifenesin increases respiratory tract fluid secretions and helps loosen phlegm and bronchial secretions. Large doses are necessary. It should be used in combination with adequate hydration.

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