Lymphangioleiomyomatosis Differential Diagnoses

Updated: Jul 27, 2015
  • Author: Joel Moss, MD, PhD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Diagnostic Considerations

Conditions with airways obstruction are as follows:

Associations between lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC) are as follows:

  • TSC is a predisposing condition
  • Several shared clinical features (eg, cystic lung disease, angiomyolipoma [AML])
  • Shared genetic features: TSC2 gene mutations can be found in AMLs and lung lesions from patients with sporadic LAM. [12, 13]

Other conditions with pulmonary cysts, honeycombing, or interstitial pattern are as follows:

Lymphatic disorders are as follows:

  • Diffuse pulmonary lymphangiomatosis
  • Pulmonary lymphangiectasis

Conditions of abnormal smooth muscle proliferation in the lung are as follows:

  • Leiomyosarcoma
  • Smooth-muscle proliferation in the lung
  • Benign metastasizing leiomyoma