Lymphangioleiomyomatosis Differential Diagnoses

Updated: Dec 22, 2019
  • Author: Joel Moss, MD, PhD; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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DDx

Diagnostic Considerations

Conditions with airways obstruction include the following:

Associations between lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC) include the following:

  • TSC is a predisposing condition

  • Several shared clinical features (eg, cystic lung disease, angiomyolipoma [AML])

  • Shared genetic features: TSC2 gene mutations can be found in AMLs and lung lesions from patients with sporadic LAM. [23, 24]

Other conditions with pulmonary cysts, honeycombing, or interstitial pattern include the following:

Lymphatic disorders include the following:

  • Diffuse pulmonary lymphangiomatosis

  • Pulmonary lymphangiectasis

Conditions of abnormal smooth muscle proliferation in the lung include the following:

  • Leiomyosarcoma

  • Smooth-muscle proliferation in the lung

  • Benign metastasizing leiomyoma