Hereditary Spastic Paraplegia Questions & Answers

Updated: Jan 14, 2019
  • Author: Nam-Jong Paik, MD, PhD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Questions & Answers

Overview

What is hereditary spastic paraplegia (HSP)?

What are the possible complications of hereditary spastic paraplegia (HSP)?

What is the pathophysiology of hereditary spastic paraplegia (HSP)?

What are the genetic causes of hereditary spastic paraplegia (HSP)?

What is the prevalence of hereditary spastic paraplegia (HSP)?

What is the prognosis of hereditary spastic paraplegia (HSP)?

What is gastrocnemius-soleus contracture in hereditary spastic paraplegia (HSP)?

What causes cold feet in hereditary spastic paraplegia (HSP)?

What causes fatigue in hereditary spastic paraplegia (HSP)?

What causes back or knee pain in hereditary spastic paraplegia (HSP)?

How are stress and depression managed in hereditary spastic paraplegia (HSP)?

Presentation

Which clinical history findings are characteristic of hereditary spastic paraplegia (HSP)?

What are the signs and symptoms of complicated hereditary spastic paraplegia (HSP)?

What are the signs and symptoms of hereditary spastic paraplegia (HSP)?

How is spasticity characterized in hereditary spastic paraplegia (HSP)?

What are the signs and symptoms of abnormal gait in hereditary spastic paraplegia (HSP)?

What causes loss of balance in hereditary spastic paraplegia (HSP)?

Which clinical history findings are characteristic of pure hereditary spastic paraplegia (HSP)?

Which physical findings are characteristic of hereditary spastic paraplegia (HSP)?

DDX

Which conditions are included in the differential diagnoses of hereditary spastic paraplegia (HSP)?

What are the differential diagnoses for Hereditary Spastic Paraplegia?

Workup

How is hereditary spastic paraplegia (HSP) diagnosed?

What is the role of electrophysiologic studies in the workup of hereditary spastic paraplegia (HSP)?

Which histologic findings are characteristic of hereditary spastic paraplegia (HSP)?

Treatment

How is hereditary spastic paraplegia (HSP) treated?

Which specialist consultations are beneficial to patients with hereditary spastic paraplegia (HSP)?

What is the role of physical therapy in the treatment of hereditary spastic paraplegia (HSP)?

What types of exercise are included in physical therapy for hereditary spastic paraplegia (HSP)?

Medications

What is the role of medications in the treatment of hereditary spastic paraplegia (HSP)?

Which medications in the drug class Anxiolytics, Benzodiazepines are used in the treatment of Hereditary Spastic Paraplegia?

Which medications in the drug class Skeletal muscle relaxants are used in the treatment of Hereditary Spastic Paraplegia?