Postpolio Syndrome Differential Diagnoses

Updated: Jun 05, 2023
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Stephen Kishner, MD, MHA  more...
  • Print

Diagnostic Considerations

These include the following:

  • Anemia

  • Chronic infection

  • Collagen disorders

  • Deconditioning

  • Depression

  • Hypothyroidism

  • Infectious myopathy

  • Myasthenia gravis

  • Weakness due to aging

  • Weight gain

Investigators initially believed that poliovirus could cause amyotrophic lateral sclerosis (ALS), but there is no evidence of this risk. Studies that show an association between both pathologies are infrequent and are greatly outnumbered by negative reports. The role, if any, of nonparalytic polio and polio vaccines in ALS is not clear. With such a high proportion of the population having antibodies to polio, it may not be feasible to differentiate ALS with respect to the presence or absence of polio antibodies. Still, further long-term studies of the classical and Western Pacific forms of ALS with respect to past polio outbreaks are desirable.

Differential Diagnoses