Chronic Pain Syndrome Differential Diagnoses

Updated: Jan 24, 2017
  • Author: Manish K Singh, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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DDx

Diagnostic Considerations

Musculoskeletal and neuropsychological disorders

Musculoskeletal and neuropsychological diseases to consider in the differential diagnosis of chronic pain syndrome (CPS) include the following:

  • Hernias (eg, obturator, sciatic, inguinal, femoral, perineal, spigelian, umbilical)
  • Neoplasia of the spinal cord or sacral nerves
  • Mononeuropathy and nerve entrapment
  • Abdominal epilepsy
  • Abdominal migraines
  • Pelvic floor pain syndrome
  • Rectus abdominis pain
  • Faulty posture and chronic pelvic pain
  • Bipolar disorders and depression
  • Chronic visceral pain syndrome
  • Chronic fatigue syndrome
  • Substance abuse

Reproductive system disorders

Conditions related to the reproductive system to consider in the differential diagnosis of CPS include the following:

  • Adenomyosis
  • Adhesions
  • Adnexal cysts
  • Cervical stenosis
  • Dyspareunia
  • Endocervical and endometrial polyps
  • Endometriosis and endosalpingiosis
  • Uterine leiomyomas
  • Ovarian retention syndrome
  • Ovarian remnant syndrome
  • Pelvic varicosities and pelvic congestion syndrome
  • Vulvodynia
  • Pelvic floor relaxation disorders
  • Accessory and supernumerary ovaries

Urinary system disorders

Urinary conditions to consider in the differential diagnosis of CPS include the following:

  • Chronic and recurrent urinary tract infections
  • Urolithiasis
  • Pelvic floor dysfunction
  • Urethral diverticulum
  • Chronic urethral syndrome

Gastrointestinal system disorders

GI conditions to consider in the differential diagnosis of CPS include the following:

  • Chronic intermittent bowel obstruction
  • Colitis
  • Chronic constipation
  • Diverticular disease
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Peritoneal cysts

Other differentials

Other conditions to consider in the differential diagnosis of CPS include the following:

  • Lateral epicondylitis
  • Lumbar degenerative disk disease
  • Lumbar facet arthropathy
  • Lumbar spondylolysis and spondylolisthesis
  • Mechanical low back pain
  • Medial epicondylitis
  • Meralgia paresthetica
  • Mononeuritis multiplex
  • Morton neuroma
  • Myofascial pain
  • Neoplastic brachial plexopathy
  • Neoplastic lumbosacral plexopathy
  • Osteoarthritis
  • Osteoporosis and spinal cord injury
  • Piriformis syndrome
  • Plantar fasciitis
  • Radiation-induced brachial plexopathy
  • Radiation-induced lumbosacral plexopathy
  • Rotator cuff disease
  • Spasticity
  • Thoracic outlet syndrome
  • Traumatic brachial plexopathy
  • Trochanteric bursitis

Differential Diagnoses