Mononeuritis Multiplex Clinical Presentation

Updated: Feb 28, 2019
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Dean H Hommer, MD  more...
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A detailed and complete medical history is vitally important in determining the possible underlying cause of mononeuritis multiplex. Pain often begins in the low back or hip and spreads to the thigh and knee on one side. The pain usually is characterized as deep and aching, with superimposed lancinating jabs that are most severe at night. Individuals with diabetes typically present with acute onset of severe, unilateral thigh pain that is followed rapidly by weakness and atrophy of the anterior thigh muscles and loss of the knee reflex. Other possible symptoms that may be reported by the patient include the following:

  • Numbness

  • Tingling

  • Abnormal sensation

  • Burning pain - Dysesthesia

  • Difficulty moving a body part - Paralysis

  • Lack of controlled movement of a body part


Physical Examination

Loss of sensation and movement may be associated with dysfunction of specific nerves. Examination reveals preservation of reflexes and good strength except in regions that have been more profoundly affected. Some common findings of mononeuritis multiplex are as follows (not listed in order of frequency):

  • Sciatic nerve dysfunction

  • Femoral nerve dysfunction

  • Common peroneal nerve dysfunction

  • Axillary nerve dysfunction

  • Radial nerve dysfunction

  • Median nerve dysfunction

  • Ulnar nerve dysfunction

  • Peroneal nerve palsy

  • Autonomic dysfunction - Dysfunction in the part of the nervous system that controls involuntary bodily functions, such as the glands, blood vessels, and heart