Brown-Sequard Syndrome Medication

Updated: Sep 07, 2018
  • Author: Carol Vandenakker-Albanese, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Medication

Medication Summary

The use of medications for Brown-Séquard syndrome is dependent on the etiology and acuity of onset. Acute treatment of traumatic SCI involves immediate dosing of methyl prednisolone. Acute immobility that is unrelated to a bleed requires anticoagulation therapy, if not contraindicated. Gastrointestinal protection is strongly recommended.

Other medications are used to manage symptoms and complications as needed, including antibiotics, antispasmodics, pain medications, and laxatives.

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Corticosteroids

Class Summary

Multiple studies have demonstrated improved outcomes for patients with traumatic SCIs who were given high-dose steroids early in the clinical course. (Although the previously mentioned study by Pollard and Apple did not find these results in incomplete cervical SCIs. [16] ) These drugs have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the body's immune response to diverse stimuli.

Methylprednisolone (A-Methapred, Medrol, Solu-Medrol, Depo-Medrol)

Methylprednisolone decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.

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