Physical Medicine and Rehabilitation for De Quervain Tenosynovitis Medication

Updated: Nov 16, 2022
  • Author: Patrick M Foye, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Medication

Medication Summary

Medications for de Quervain tenosynovitis serve primarily to decrease pain and inflammation. The most commonly used agents are oral nonsteroidal anti-inflammatory drugs (NSAIDs) and focally injected corticosteroid medication; these are employed in conjunction with the rest of the rehabilitation plan.

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Nonsteroidal Anti-inflammatory Drugs

Class Summary

Oral NSAIDs may decrease pain and inflammation in de Quervain tenosynovitis. Various oral NSAIDs may be used, although, none holds a clear distinction as the drug of choice. The choice of NSAID is largely a matter of convenience (eg, how frequently doses must be taken to achieve adequate analgesic and anti-inflammatory effects) and cost. Many NSAIDs are available either with or without a prescription. [48]

In contrast with the widespread systemic distribution of an oral anti-inflammatory drug, a topical patch can achieve focal placement of a potent anti-inflammatory agent at the site of maximal tenderness or inflammation, with minimal systemic distribution.

Ibuprofen (Motrin, Advil, Nuprin, Rufen)

DOC for patients with mild to moderate pain. Ibuprofen inhibits inflammatory reactions and pain, possibly by decreasing prostaglandin synthesis.

Diclofenac topical

Inhibits inflammatory reactions and pain, possibly by decreasing prostaglandin synthesis.

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Corticosteroids

Class Summary

In contrast with the widespread systemic distribution of an oral anti-inflammatory drug, a local corticosteroid injection can achieve focal placement of a potent anti-inflammatory agent at the site of maximal tenderness or inflammation. A variety of corticosteroid preparations are available. Mix the corticosteroid with a local anesthetic agent prior to injection.

Methylprednisolone (Depo-Medrol)

Decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and by reversing increased capillary permeability.

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