Eosinophilia-Myalgia Syndrome Treatment & Management

Updated: Dec 01, 2017
  • Author: William E Monaco, MD; Chief Editor: Herbert S Diamond, MD  more...
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Treatment

Medical Care

The first and most important step is to discontinue the L-tryptophan or other possible offending agent(s). No medication has been shown to alter the course of the disease, but high-dose steroids (eg, equivalent of prednisone 60 mg/day) may be helpful in acutely ill patients.  However, the response to corticosteroids is not as dramatic as in patients with other causes of eosinophilia like eosinophilic fasciitis.  Other care should be directed symptomatically. [28]

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Consultations

Depending on the clinical features, consultation with a neurologist, rheumatologist, pulmonologist, or dermatologist may be needed. Consultation with a surgeon may be necessary for muscle biopsy.

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Diet

Patients should avoid all herbal supplements and other over-the-counter medication unless further information about the pathophysiology of EMS is elucidated. [28]

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Activity

Activity may exacerbate the myalgias or muscle cramps. During the acute illness, patient may require bed rest if their symptoms are intense. Over the long term, strenuous activity should be avoided only if it causes symptoms to recur.

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