Felty Syndrome Questions & Answers

1. Patel R, Akhondi H. Felty Syndrome. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Felty AR. Chronic arthritis in the adult associated with splenomegaly and leukopenia. Bull Johns Hopkins Hosp. 1924. 35:16.

3. Burks EJ, Loughran TP Jr. Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. Blood Rev. 2006 Sep. 20(5):245-66. [QxMD MEDLINE Link].

4. Lazarou I, Petitpierre N, Auger I, Reber G, Roux-Lombard P, Boehlen F, et al. Felty's syndrome and hypofibrinogenemia: an unusual target for anti-cyclic citrullinated peptide antibodies?. Mod Rheumatol. 2015 Sep. 25 (5):790-3. [QxMD MEDLINE Link].

5. Hellmich B, Csernok E, Schatz H, et al. Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. Arthritis Rheum. 2002 Sep. 46(9):2384-91. [QxMD MEDLINE Link].

6. Campion G, Maddison PJ, Goulding N, James I, Ahern MJ, Watt I, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore). 1990 Mar. 69(2):69-80. [QxMD MEDLINE Link].

7. Gridley G, Klippel JH, Hoover RN, et al. Incidence of cancer among men with the Felty syndrome. Ann Intern Med. 1994 Jan 1. 120(1):35-9. [QxMD MEDLINE Link].

8. Jain T, Mittal C, Sengupta R, Rubin B. Non-articular Felty's syndrome: An uncommon diagnosis. Neth J Med. 2015 Nov. 73 (9):435-6. [QxMD MEDLINE Link]. [Full Text].

9. Savola P, Brück O, Olson T, Kelkka T, Kauppi MJ, Kovanen PE, et al. Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Haematologica. 2017 Dec 7. [QxMD MEDLINE Link]. [Full Text].

10. Brücker R, Schlumpf U. [Felty syndrome: a therapy-resistant variant of chronic rheumatoid arthritis? 2 case reports and literature review]. Praxis (Bern 1994). 1996 Apr 16. 85(16):534-40. [QxMD MEDLINE Link].

11. Ghavami A, Genevay S, Fulpius T, et al. Etanercept in treatment of Felty's syndrome. Ann Rheum Dis. 2005 Jul. 64(7):1090-1. [QxMD MEDLINE Link].

12. Sordet C, Gottenberg JE, Hellmich B, et al. Lack of efficacy of rituximab in Felty's syndrome. Ann Rheum Dis. 2005 Feb. 64(2):332-3. [QxMD MEDLINE Link].

13. Chandra PA, Margulis Y, Schiff C. Rituximab is useful in the treatment of Felty's syndrome. Am J Ther. 2008 Jul-Aug. 15(4):321-2. [QxMD MEDLINE Link].

14. Weinreb N, Rabinowitz A, Dellaripa PF. Beneficial response to rituximab in refractory Felty Syndrome. J Clin Rheumatol. 2006 Feb. 12(1):48. [QxMD MEDLINE Link].

15. Tomi AL, Lioté F, Ea HK. One case of Felty's syndrome efficiently treated with rituximab. Joint Bone Spine. 2012 Mar 6. [QxMD MEDLINE Link].

16. Narváez J, Domingo-Domenech E, Gómez-Vaquero C, López-Vives L, Estrada P, Aparicio M, et al. Biological agents in the management of Felty's syndrome: a systematic review. Semin Arthritis Rheum. 2012 Apr. 41(5):658-68. [QxMD MEDLINE Link].

17. Sarp U, Ataman S. A benefiicial long-term and consistent response to rituximab in the treatment of refractory neutropenia and arthritis in a patient with Felty syndrome. J Clin Rheumatol. October, 2014. 207:398. [QxMD MEDLINE Link].

18. Li R, Wan Q, Chen P, Mao S, Wang Q, Li X, et al. Tocilizumab treatment in Felty's syndrome. Rheumatol Int. 2020 Jul. 40 (7):1143-1149. [QxMD MEDLINE Link].

19. Kimura Y, Yoshida S. Successful abatacept treatment for Felty's syndrome in a patient with rheumatoid arthritis. Mod Rheumatol Case Rep. 2020 Jul. 4 (2):168-170. [QxMD MEDLINE Link].

20. Talip F, Walker N, Khan W, et al. Treatment of Felty's syndrome with leflunomide. J Rheumatol. 2001 Apr. 28(4):868-70. [QxMD MEDLINE Link].

21. Ishikawa K, Tsukada Y, Tamura S, et al. Salazosulfapyridine-induced remission of Felty's syndrome along with significant reduction in neutrophil-bound immunoglobulin G. J Rheumatol. 2003 Feb. 30(2):404-6. [QxMD MEDLINE Link].

Richard M Keating, MD, FACR, FACP Associate Program Director, Rheumatology Fellowship, Scripps Clinic

Richard M Keating, MD, FACR, FACP is a member of the following medical societies: American College of Physicians, American College of Rheumatology

Disclosure: Nothing to disclose.

Kavitta B Allem, MD Clinical Instructor, Rheumatologist, Scripps Clinic Rheumatology

Disclosure: Nothing to disclose.

Herbert S Diamond, MD Visiting Professor of Medicine, Division of Rheumatology, State University of New York Downstate Medical Center; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, Phi Beta Kappa

Disclosure: Nothing to disclose.

Dana A Reddy, MD Rheumatologist, Sharp Community Medical Group

Disclosure: Nothing to disclose.

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