Familial Mediterranean Fever Medication

Updated: Sep 30, 2016
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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Medication Summary

The goals of therapy are to reduce morbidity and to prevent complications.


Anti-inflammatory agents

Class Summary

Colchicine is the drug of choice for familial Mediterranean fever (FMF).

Colchicine (Colcrys)

Decreases leukocyte motility and phagocytosis in inflammatory responses.


Interleukin Inhibitors

Class Summary

In patients with FMF, uninhibited pyrin activity results in uncontrolled production of IL-1 which causes inflammation and may be accompanied by joint pain, swelling, muscle pain, and skin rash.

Canakinumab (Ilaris)

Human monoclonal anti-human IL-1beta antibody of the IgG1/kappa isotype. It binds to human IL­1beta and neutralizes its activity by blocking its interaction with IL-1 receptors. It is indicated for the treatment of FMF in adult and pediatric patients.