Familial Mediterranean Fever Questions & Answers

Updated: May 14, 2018
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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Questions & Answers

Overview

What is familial Mediterranean fever (FMF)?

What is the pathophysiology of familial Mediterranean fever (FMF)?

What is the prevalence of familial Mediterranean fever (FMF)?

What is the mortality and morbidity of familial Mediterranean fever (FMF)?

Which patient groups have higher incidence of familial Mediterranean fever (FMF)?

Presentation

Which clinical history findings are characteristic of familial Mediterranean fever (FMF)?

What are peritoneal symptoms of familial Mediterranean fever (FMF)?

What are pleural and pericardial symptoms of familial Mediterranean fever (FMF)?

What are synovial symptoms of familial Mediterranean fever (FMF)?

What are the signs and symptoms of familial Mediterranean fever (FMF)?

What are the signs and symptoms of amyloidosis in familial Mediterranean fever (FMF)?

Which physical findings are characteristic of familial Mediterranean fever (FMF)?

What causes familial Mediterranean fever (FMF)?

DDX

Which conditions should be included in the differential diagnoses of familial Mediterranean fever (FMF)?

What are the differential diagnoses for Familial Mediterranean Fever?

Workup

What is the role of lab studies in the workup of familial Mediterranean fever (FMF)?

What is the role of genetic testing in the workup of familial Mediterranean fever (FMF)?

What are recommendations for genetic diagnosis of familial Mediterranean fever (FMF)?

Which findings on imaging studies suggest familial Mediterranean fever (FMF)?

Which histologic findings are characteristic of familial Mediterranean fever (FMF)?

What is the role of biopsy in the diagnosis of familial Mediterranean fever (FMF)?

Treatment

What is the role of colchicine in the treatment of familial Mediterranean fever (FMF)?

What is the role of biologic therapy in the management of familial Mediterranean fever (FMF)?

What is the role of rilonacept and canakinumab in the treatment of familial Mediterranean fever (FMF)?

How are specific comorbidities managed in familial Mediterranean fever (FMF)?

What is the role of surgery in the treatment of familial Mediterranean fever (FMF)?

When is consultation with a rheumatologist indicated for patients with familial Mediterranean fever (FMF)?

Guidelines

What are the European League Against Rheumatism (EULAR) treatment guidelines for familial Mediterranean fever (FMF)?

Medications

What is the role of medications in the treatment of familial Mediterranean fever (FMF)?

Which medications in the drug class Interleukin Inhibitors are used in the treatment of Familial Mediterranean Fever?

Which medications in the drug class Anti-inflammatory agents are used in the treatment of Familial Mediterranean Fever?

Follow-up

What is included in long-term monitoring of familial Mediterranean fever (FMF)?

What are complications in familial Mediterranean fever (FMF)?

What is the prognosis of familial Mediterranean fever (FMF)?

What is the importance of patient education in familial Mediterranean fever (FMF)?