Polyarteritis Nodosa Questions & Answers

Updated: Dec 03, 2018
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Questions & Answers

Overview

What is polyarteritis nodosa (PAN)?

Which areas of the body are commonly affected by polyarteritis nodosa (PAN)?

How has the understanding of polyarteritis nodosa (PAN) evolved since the systemic vasculitic disorders were first described?

What are the ACR diagnostic criteria for polyarteritis nodosa (PAN)?

How is polyarteritis nodosa (PAN) distinguished from microscopic polyangiitis (MPA)?

What are the stages of polyarteritis nodosa (PAN)?

How can providers improve treatment compliance in patients with polyarteritis nodosa (PAN)?

What is the pathophysiology of polyarteritis nodosa (PAN)?

What is the relationship between polyarteritis nodosa (PAN) and hepatitis B virus (HBV)?

What are the genetic features of polyarteritis nodosa (PAN)?

Which diseases are associated with polyarteritis nodosa (PAN)?

How common is polyarteritis nodosa (PAN) in the US?

What is the international incidence of polyarteritis nodosa (PAN)?

What are the sex-and age-related demographics of polyarteritis nodosa (PAN)?

What is the prognosis of idiopathic polyarteritis nodosa (PAN)?

What is the prognosis of HBV-related polyarteritis nodosa (PAN)?

What is the prognosis of HCV-related polyarteritis nodosa (PAN)?

How common are complications of polyarteritis nodosa (PAN)?

What are the complications of polyarteritis nodosa (PAN)?

What is the mortality of polyarteritis nodosa (PAN)?

What are the factors that predict an increased risk of mortality in polyarteritis nodosa (PAN)?

Presentation

What is the typical patient history in polyarteritis nodosa (PAN)?

What are the constitutional and musculoskeletal symptoms of polyarteritis nodosa (PAN)?

What are the CNS symptoms of polyarteritis nodosa (PAN)?

What are the peripheral nervous system symptoms of polyarteritis nodosa (PAN)?

What are the cutaneous symptoms of polyarteritis nodosa (PAN)?

What are the GI symptoms of polyarteritis nodosa (PAN)?

What are the renal symptoms of polyarteritis nodosa (PAN)?

What are the uncommon symptoms of polyarteritis nodosa (PAN)?

What are the cutaneous symptoms of polyarteritis nodosa (PAN)?

What is the role of a physical exam in the diagnosis of polyarteritis nodosa (PAN)?

Which signs of polyarteritis nodosa (PAN) are noted in the physical exam?

What are the neurologic symptoms of polyarteritis nodosa (PAN)?

What are the GI symptoms of polyarteritis nodosa (PAN)?

What are the renal symptoms of polyarteritis nodosa (PAN)?

What are the cardiac symptoms of polyarteritis nodosa (PAN)?

What are the ophthalmologic symptoms of polyarteritis nodosa (PAN)?

What are additional symptoms of polyarteritis nodosa (PAN)?

What are the unusual presentations of polyarteritis nodosa (PAN)?

DDX

What are the diagnostic considerations in polyarteritis nodosa (PAN)?

What are the differential diagnoses for Polyarteritis Nodosa?

Workup

What are the approach considerations in the workup of polyarteritis nodosa (PAN)?

Which lab study findings are associated with polyarteritis nodosa (PAN)?

What is the role of angiography in the diagnosis of polyarteritis nodosa (PAN)?

Which imaging studies are indicated in the workup of polyarteritis nodosa (PAN) besides angiography?

What is the role of biopsy in the workup of polyarteritis nodosa (PAN)?

What are the histologic findings in polyarteritis nodosa (PAN)?

Which instrument is used to stage the level of disease activity in polyarteritis nodosa (PAN) in children?

Treatment

What are the approach considerations in the treatment of polyarteritis nodosa (PAN)?

How is idiopathic polyarteritis nodosa (PAN) treated?

What is the role of glucocorticoids in the treatment of polyarteritis nodosa (PAN)?

What is the role of cyclophosphamide in the treatment of polyarteritis nodosa (PAN)?

What are the complications of steroids and cyclophosphamide in the treatment of polyarteritis nodosa (PAN)?

How is HBV-related polyarteritis nodosa (PAN) treated?

How are steroids administered to patients in the treatment of HBV-related polyarteritis nodosa (PAN)?

How are antiviral agents administered to patients in the treatment of HBV-related polyarteritis nodosa (PAN)?

How is plasma exchange (plasmapheresis) administered to patients in the treatment of HBV-related polyarteritis nodosa (PAN)?

What is the treatment of choice for HCV-related polyarteritis nodosa (PAN)?

What is the treatment of choice for cutaneous polyarteritis nodosa (PAN)?

Which specialist consultations are indicated in the treatment of polyarteritis nodosa (PAN)?

What long-term monitoring is indicated in the treatment of polyarteritis nodosa (PAN)?

Medications

Which drugs are used in the treatment of polyarteritis nodosa (PAN)?

Which medications in the drug class Antineoplastic agents are used in the treatment of Polyarteritis Nodosa?

Which medications in the drug class Corticosteroids are used in the treatment of Polyarteritis Nodosa?