Raynaud Phenomenon Differential Diagnoses

Updated: Sep 06, 2017
  • Author: Heather Hansen-Dispenza, MD; Chief Editor: Herbert S Diamond, MD  more...
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DDx

Diagnostic Considerations

Anatomic syndromes that may be confused with Raynaud phenomenon include the following:

Miscellaneous circulatory syndromes that may be confused with Raynaud phenomenon include the following:

Vasospastic syndromes that may be confused with Raynaud phenomenon include the following:

  • Livedo reticularis
  • Acrocyanosis
  • Chilblains

Other problems to be considered in the differential diagnosis of Raynaud phenomenon include the following:

  • Cryoglobulinemia, mixed or type 3, associated with hepatitis B and C
  • Cryoglobulinemia, monoclonal or type I
  • Fabry disease
  • Leukemia
  • Lymphoma
  • Mycoplasma infection with cold agglutinins
  • Myeloma
  • Scleroderma, diffuse and localized (CREST syndrome)
  • Vibration injury [22]
  • Vinyl chloride exposure
  • Waldenström macroglobulinemia

Drugs to be considered in the differential diagnosis of Raynaud phenomenon include the following:

  • Alfa-interferon
  • Antineoplastics (eg, vinca alkaloids, bleomycin, cisplatin)
  • Beta-adrenergic blocking drugs
  • Bromocriptine
  • Cocaine
  • Cyclosporine
  • Ergot alkaloids
  • Oral contraceptives

Differential Diagnoses