Relapsing Polychondritis Questions & Answers

Updated: Dec 06, 2018
  • Author: Nicholas Compton, MD; Chief Editor: Herbert S Diamond, MD  more...
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Questions & Answers

Overview

What is relapsing polychondritis (RP)?

When was relapsing polychondritis (RP) first identified?

What is the pathogenesis of relapsing polychondritis (RP)?

What is the role of humoral response in the pathophysiology of relapsing polychondritis (RP)?

What is the role of cellular response in the pathophysiology of relapsing polychondritis (RP)?

How can animal models be used to explain the autoimmune origins of relapsing polychondritis (RP)?

Which autoimmune disorders are associated with relapsing polychondritis (RP)?

What is the role of gut microbiome alterations in the pathophysiology of relapsing polychondritis (RP)?

What is the prevalence of relapsing polychondritis (RP) in the US?

What are the mortality rates of relapsing polychondritis (RP)?

What are the possible complications of relapsing polychondritis (RP)?

Which patient groups have the highest prevalence of relapsing polychondritis (RP)?

Presentation

Which clinical history findings are characteristic of relapsing polychondritis (RP)?

What are the clinical phenotypes of relapsing polychondritis (RP)?

What is the clinical presentation of nasal chondritis in relapsing polychondritis (RP)?

When is biopsy indicated for the workup of relapsing polychondritis (RP)?

What are the McAdam et al diagnostic criteria for relapsing polychondritis (RP)?

What are the Damiani and Levine diagnostic criteria for relapsing polychondritis (RP)?

What are the Michet et al diagnostic criteria for relapsing polychondritis (RP)?

What the signs and symptoms of relapsing polychondritis (RP)?

Which physical findings are characteristic of auricular chondritis in relapsing polychondritis (RP)?

Which physical findings are characteristic of arthritis in relapsing polychondritis (RP)?

Which physical findings are characteristic of ocular inflammation in relapsing polychondritis (RP)?

Which ocular findings suggest relapsing polychondritis (RP)?

Which physical findings are characteristic of respiratory tract chondritis in relapsing polychondritis (RP)?

Which physical findings are characteristic of audiovestibular damage in relapsing polychondritis (RP)?

Which cardiovascular findings are characteristic of relapsing polychondritis (RP)?

Which skin lesion findings are characteristic of relapsing polychondritis (RP)?

Which cutaneous findings are characteristic of relapsing polychondritis (RP)?

Which mouth and genital findings are characteristic of relapsing polychondritis (RP)?

Which CNS findings are characteristic of relapsing polychondritis (RP)?

Which renal findings are characteristic of relapsing polychondritis (RP)?

What causes relapsing polychondritis (RP)?

DDX

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP)?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with auricular chondritis?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with nasal chondritis or saddle-nose deformity?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with inflammatory arthritis?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with ocular inflammation?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with tracheal obstruction?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with respiratory tree chondritis?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with CNS alterations?

Which conditions are included in the differential diagnoses of relapsing polychondritis (RP) with aortitis?

What are the differential diagnoses for Relapsing Polychondritis?

Workup

What is the role of lab testing in the workup of relapsing polychondritis (RP)?

Which lab studies are indicated in the workup of vasculitis in relapsing polychondritis (RP)?

What is the role of a purified protein derivative test in the workup of relapsing polychondritis (RP)?

What is the role of cultures in the workup of relapsing polychondritis (RP)?

What is the role of chest radiography in the workup of relapsing polychondritis (RP)?

What is the role of a spiral CT scan in the workup of relapsing polychondritis (RP)?

What is the role of FDG-PET/CT scanning in the workup of relapsing polychondritis (RP)?

What is the role of MRI in the workup of relapsing polychondritis (RP)?

What is the role of pharyngotracheography m in the workup of relapsing polychondritis (RP)?

What is the role of scintigraphy in the workup of relapsing polychondritis (RP)?

What is the role of pulmonary function testing (PFT) in the workup of relapsing polychondritis (RP)?

What is the role of ECG and echocardiography in the workup of relapsing polychondritis (RP)?

How is ventilation support provided in relapsing polychondritis (RP)?

What is the role of biopsy in the workup of relapsing polychondritis (RP)?

Which histologic findings are characteristic of relapsing polychondritis (RP)?

Treatment

How is relapsing polychondritis (RP) treated?

What is the role of surgery in the treatment of relapsing polychondritis (RP)?

Which specialist consultations are beneficial to patients with relapsing polychondritis (RP)?

Medications

Which medications are used in the treatment of relapsing polychondritis (RP)?

Which medications in the drug class Interleukin-1 receptor antagonists are used in the treatment of Relapsing Polychondritis?

Which medications in the drug class Anti-CD20 antigen on B lymphocytes are used in the treatment of Relapsing Polychondritis?

Which medications in the drug class Monoclonal antibodies - Antitumor necrosis factor-alpha inhibitors are used in the treatment of Relapsing Polychondritis?

Which medications in the drug class Anti-inflammatory agents are used in the treatment of Relapsing Polychondritis?

Which medications in the drug class Disease-modifying antirheumatic agents are used in the treatment of Relapsing Polychondritis?

Which medications in the drug class Corticosteroids are used in the treatment of Relapsing Polychondritis?

Follow-up

What is the prognosis of relapsing polychondritis (RP)?