Scleroderma Differential Diagnoses

Updated: Mar 01, 2023
  • Author: Abhishek Nandan, MD; Chief Editor: Herbert S Diamond, MD  more...
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Diagnostic Considerations

The following disorders may present clinical similarities with systemic sclerosis (“scleroderma mimics”) and need to be included in the differential diagnosis: [96, 97, 98, 99]

Gadolinium-based contrast agents, bleomycin, pentazocine, and several other drugs and chemicals have been shown to cause disorders resembling systemic sclerosis. These must be considered in the differential diagnosis.