Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Questions & Answers

Updated: Dec 24, 2018
  • Author: Spencer T Lowe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Questions & Answers

Overview

What is eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome)?

What are the diagnostic criteria for EGPA (Churg-Strauss syndrome)?

What is hypereosinophilic asthma with systemic manifestations and what is its relationship to EGPA (Churg-Strauss syndrome)?

What is the pathophysiology of EGPA (Churg-Strauss syndrome)?

What is the incidence of EGPA (Churg-Strauss syndrome)?

What is the mortality and morbidity of EGPA (Churg-Strauss syndrome)?

What is the epidemiology of EGPA (Churg-Strauss syndrome)?

Presentation

What are the phases of EGPA (Churg-Strauss syndrome)?

How is the vasculitic phase of EGPA (Churg-Strauss syndrome) characterized?

What are the signs and symptoms of EGPA (Churg-Strauss syndrome)?

What causes EGPA (Churg-Strauss syndrome)?

What are the physical findings in EGPA (Churg-Strauss syndrome)?

What are the dermatologic findings in EGPA (Churg-Strauss syndrome)?

What are the upper respiratory system findings in EGPA (Churg-Strauss syndrome)?

What are the lower respiratory system findings in EGPA (Churg-Strauss syndrome)?

What are the cardiovascular findings in EGPA (Churg-Strauss syndrome)?

What are the renal findings in EGPA (Churg-Strauss syndrome)?

What are the GI findings in EGPA (Churg-Strauss syndrome)?

What are the neurologic findings in EGPA (Churg-Strauss syndrome)?

How are ANCA-positive and ANCA-negative EGPA (Churg-Strauss syndrome) differentiated?

DDX

What are other problems to be considered in the differential diagnosis of EGPA (Churg-Strauss syndrome)?

What are the differential diagnoses for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)?

Workup

What are the guidelines on the workup of EGPA (Churg-Strauss syndrome)?

What lab study findings are associated with EGPA (Churg-Strauss syndrome)?

Which imaging studies are indicated in the workup of EGPA (Churg-Strauss syndrome)?

What are the chest radiography findings in EGPA (Churg-Strauss syndrome)?

What are the CT findings in EGPA (Churg-Strauss syndrome)?

Which studies are indicated for specific organ-system involvement in the workup of EGPA (Churg-Strauss syndrome)?

What are the histologic findings in EGPA (Churg-Strauss syndrome)?

What is the role of biopsy in the workup of EGPA (Churg-Strauss syndrome)?

Treatment

Which drugs are used in the treatment of EGPA (Churg-Strauss syndrome)?

Which specialist consultations are indicated in the treatment of EGPA (Churg-Strauss syndrome)?

Medications

What is the cornerstone of therapy for EGPA (Churg-Strauss syndrome)?

Which medications in the drug class Monoclonal Antibodies, Anti-asthmatics are used in the treatment of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)?

Which medications in the drug class Cytotoxic agents are used in the treatment of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)?

Which medications in the drug class Corticosteroids are used in the treatment of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)?

Follow-up

What are the monitoring procedures for patients with EGPA (Churg-Strauss syndrome)?

Which medications are used in the inpatient treatment of EGPA (Churg-Strauss syndrome)?

What is the prognosis of EGPA (Churg-Strauss syndrome)?