Paget Disease Questions & Answers

Updated: Dec 21, 2018
  • Author: Mujahed M Alikhan, MD; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Questions & Answers

Overview

What is Paget disease?

What is the pathophysiology of Paget disease?

What causes Paget disease?

What is the role of genetics in the etiology of Paget disease?

Which environmental factors increase the risk of Paget disease?

What is the role of inflammation in the etiology of Paget disease?

What is the prevalence of Paget disease in the US?

What is the global prevalence of Paget disease?

Which patient groups have the highest prevalence of Paget disease?

What is the prognosis of Paget disease?

What is included in patient education about Paget disease?

Presentation

Which clinical history findings are characteristic of Paget disease?

Which physical findings are characteristic of Paget disease?

What are the possible complications of Paget disease?

What are the possible skeletal complications of Paget disease?

Which malignancies are associated with Paget disease?

What are the possible neuromuscular complications of Paget disease?

Which degenerative joint diseases are associated with Paget disease?

What are the possible cardiovascular complications of Paget disease?

DDX

How is osteomalacia differentiated from Paget disease?

How is Paget disease differentiated from skeletal metastasis?

Workup

How is Paget disease diagnosed?

What is the role of bone-specific alkaline phosphatase (BSAP) measurement in the workup of Paget disease?

What is the role of urinary markers in the workup of Paget disease?

What is the role of radiography in the workup of Paget disease?

What is the role of nuclear imaging in the workup of Paget disease?

What is the role of MRI and CT scanning in the workup of Paget disease?

Which histologic findings are characteristic of Paget disease?

Treatment

How is Paget disease treated?

What is the role of medications in the treatment of Paget disease?

What is the role of alendronate in the treatment of Paget disease?

What is the role of pamidronate in the treatment of Paget disease?

What is the role of risedronate in the treatment of Paget disease?

What is the role of tiludronate in the treatment of Paget disease?

What is the role of zoledronic acid in the treatment of Paget disease?

How are malignancies treated in patients with Paget disease?

What is the role of surgery in the treatment of Paget disease?

How is spinal stenosis treated in patients with Paget disease?

Which dietary modifications are used in the treatment of Paget disease?

Which activity modifications are used in the treatment of Paget disease?

When is transfer indicated for the treatment of Paget disease?

How is Paget disease (PD) prevented?

Which specialist consultations are beneficial to patients with Paget disease?

What is included in the long-term monitoring of Paget disease?

Guidelines

What are the Endocrine Society guidelines on diagnosis and treatment of Paget disease?

Medications

What is the first-line medication used in the treatment of Paget disease?