Paget Disease Questions & Answers

1. Bouchette P, Boktor SW. Paget Disease. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].

2. Lalam RK, Cassar-Pullicino VN, Winn N. Paget Disease of Bone. Semin Musculoskelet Radiol. 2016 Jul. 20 (3):287-299. [QxMD MEDLINE Link].

3. Paget J. On a Form of Chronic Inflammation of Bones (Osteitis Deformans). Med Chir Trans. 1877. 60:37-64.9. [QxMD MEDLINE Link].

4. Senthil V, Balaji S. Monostotic Paget Disease of the Lumbar Vertebrae: A Pathological Mimicker. Neurospine. 2018 Jun. 15 (2):182-186. [QxMD MEDLINE Link]. [Full Text].

5. Alexandersen P, Peris P, Guañabens N, Byrjalsen I, Alvarez L, Solberg H, et al. Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone. J Bone Miner Res. 2005 Apr. 20(4):588-95. [QxMD MEDLINE Link].

6. Polyzos SA, Cundy T, Mantzoros CS. Juvenile Paget disease. Metabolism. 2017 Nov 22. [QxMD MEDLINE Link].

7. Hughes AE, Shearman AM, Weber JL, Barr RJ, Wallace RG, Osterberg PH, et al. Genetic linkage of familial expansile osteolysis to chromosome 18q. Hum Mol Genet. 1994 Feb. 3(2):359-61. [QxMD MEDLINE Link].

8. Neale SD, Schulze E, Smith R, Athanasou NA. The influence of serum cytokines and growth factors on osteoclast formation in Paget's disease. QJM. 2002 Apr. 95(4):233-40. [QxMD MEDLINE Link].

9. Hoyland JA, Freemont AJ, Sharpe PT. Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res. 1994 Jan. 9(1):75-80. [QxMD MEDLINE Link].

10. Schweitzer DH, Oostendorp-van de Ruit M, Van der Pluijm G, Löwik CW, Papapoulos SE. Interleukin-6 and the acute phase response during treatment of patients with Paget's disease with the nitrogen-containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate. J Bone Miner Res. 1995 Jun. 10(6):956-62. [QxMD MEDLINE Link].

11. Menaa C, Barsony J, Reddy SV, Cornish J, Cundy T, Roodman GD. 1,25-Dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease. J Bone Miner Res. 2000 Feb. 15(2):228-36. [QxMD MEDLINE Link].

12. Hoyland J, Sharpe PT. Upregulation of c-fos protooncogene expression in pagetic osteoclasts. J Bone Miner Res. 1994 Aug. 9(8):1191-4. [QxMD MEDLINE Link].

13. Usategui-Martín R, García-Aparicio J, Corral-Gudino L, Calero-Paniagua I, Del Pino-Montes J, González Sarmiento R. Polymorphisms in autophagy genes are associated with paget disease of bone. PLoS One. 2015. 10 (6):e0128984. [QxMD MEDLINE Link].

14. Divisato G, Formicola D, Esposito T, Merlotti D, Pazzaglia L, Del Fattore A, et al. ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. Am J Hum Genet. 2016 Feb 4. 98 (2):275-86. [QxMD MEDLINE Link]. [Full Text].

15. Rebel A, Basle M, Pouplard A, Malkani K, Filmon R, Lepatezour A. Towards a viral etiology for Paget's disease of bone. Metab Bone Dis Relat Res. 1981. 3(4-5):235-8. [QxMD MEDLINE Link].

16. Altman RD, Bloch DA, Hochberg MC, Murphy WA. Prevalence of pelvic Paget's disease of bone in the United States. J Bone Miner Res. 2000 Mar. 15(3):461-5. [QxMD MEDLINE Link].

17. Poór G, Donáth J, Fornet B, Cooper C. Epidemiology of Paget's disease in Europe: the prevalence is decreasing. J Bone Miner Res. 2006 Oct. 21(10):1545-9. [QxMD MEDLINE Link].

18. Cooper C, Dennison E, Schafheutle K, Kellingray S, Guyer P, Barker D. Epidemiology of Paget's disease of bone. Bone. 1999 May. 24(5 Suppl):3S-5S. [QxMD MEDLINE Link].

19. Guañabens N, Garrido J, Gobbo M, Piga AM, del Pino J, Torrijos A, et al. Prevalence of Paget's disease of bone in Spain. Bone. 2008 Dec. 43(6):1006-9. [QxMD MEDLINE Link].

20. Barker DJ, Chamberlain AT, Guyer PB, Gardner MJ. Paget's disease of bone: the Lancashire focus. Br Med J. 1980 Apr 26. 280(6222):1105-7. [QxMD MEDLINE Link]. [Full Text].

21. Cook MJ, Pye SR, Lunt M, Dixon WG, Ashcroft DM, O'Neill TW. Incidence of Paget's disease of bone in the UK: evidence of a continuing decline. Rheumatology (Oxford). 2021 Dec 1. 60 (12):5668-5676. [QxMD MEDLINE Link].

22. Doyle T, Gunn J, Anderson G, Gill M, Cundy T. Paget's disease in New Zealand: evidence for declining prevalence. Bone. 2002 Nov. 31(5):616-9. [QxMD MEDLINE Link].

23. Bouchette P, Boktor SW. Paget Disease. 2017 Jun. [QxMD MEDLINE Link]. [Full Text].

24. Miladi S, Rouached L, Maatallah K, Rahmouni S, Fazaa A, Sellami M, et al. Complications of Paget Bone Disease: A Study of 69 Patients. Curr Rheumatol Rev. 2021. 17 (4):390-396. [QxMD MEDLINE Link].

25. Dove J. Complete fractures of the femur in Paget's disease of bone. J Bone Joint Surg Br. 1980 Feb. 62-B(1):12-7. [QxMD MEDLINE Link].

26. Mangham DC, Davie MW, Grimer RJ. Sarcoma arising in Paget's disease of bone: declining incidence and increasing age at presentation. Bone. 2009 Mar. 44(3):431-6. [QxMD MEDLINE Link].

27. Goldman AB, Bullough P, Kammerman S, Ambos M. Osteitis deformans of the hip joint. AJR Am J Roentgenol. 1977 Apr. 128(4):601-6. [QxMD MEDLINE Link].

28. Lluberas-Acosta G, Hansell JR, Schumacher HR Jr. Paget's disease of bone in patients with gout. Arch Intern Med. 1986 Dec. 146(12):2389-92. [QxMD MEDLINE Link].

29. Alvarez L, Guañabens N, Peris P, Monegal A, Bedini JL, Deulofeu R, et al. Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. J Bone Miner Res. 1995 Mar. 10(3):458-65. [QxMD MEDLINE Link].

30. Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008 Sep. 83(9):1032-45. [QxMD MEDLINE Link]. [Full Text].

31. Smith SE, Murphey MD, Motamedi K, Mulligan ME, Resnik CS, Gannon FH. From the archives of the AFIP. Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation. Radiographics. 2002 Sep-Oct. 22(5):1191-216. [QxMD MEDLINE Link].

32. Seitz S, Priemel M, Zustin J, Beil FT, Semler J, Minne H, et al. Paget's disease of bone: histologic analysis of 754 patients. J Bone Miner Res. 2009 Jan. 24(1):62-9. [QxMD MEDLINE Link].

33. Lyles KW, Siris ES, Singer FR, Meunier PJ. A clinical approach to diagnosis and management of Paget's disease of bone. J Bone Miner Res. 2001 Aug. 16(8):1379-87. [QxMD MEDLINE Link].

34. Corral-Gudino L, Tan AJ, Del Pino-Montes J, Ralston SH. Bisphosphonates for Paget's disease of bone in adults. Cochrane Database Syst Rev. 2017 Dec 1. 12:CD004956. [QxMD MEDLINE Link].

35. Silverman SL. Paget disease of bone: therapeutic options. J Clin Rheumatol. 2008 Oct. 14(5):299-305. [QxMD MEDLINE Link].

36. Abelson A. A review of Paget's disease of bone with a focus on the efficacy and safety of zoledronic acid 5 mg. Curr Med Res Opin. 2008 Mar. 24(3):695-705. [QxMD MEDLINE Link].

37. Woitge HW, Oberwittler H, Heichel S, Grauer A, Ziegler R, Seibel MJ. Short- and long-term effects of ibandronate treatment on bone turnover in Paget disease of bone. Clin Chem. 2000 May. 46(5):684-90. [QxMD MEDLINE Link].

38. Reid IR, Wattie D, Gamble GD, Kalluru R, Cundy T. Long-Term Effects of Intravenous Ibandronate in Paget's Disease of Bone. Calcif Tissue Int. 2017 Mar. 100 (3):250-254. [QxMD MEDLINE Link].

39. González DC, Mautalen CA. Short-term therapy with oral olpadronate in active Paget's disease of bone. J Bone Miner Res. 1999 Dec. 14(12):2042-7. [QxMD MEDLINE Link].

40. Miller PD, Brown JP, Siris ES, Hoseyni MS, Axelrod DW, Bekker PJ. A randomized, double-blind comparison of risedronate and etidronate in the treatment of Paget's disease of bone. Paget's Risedronate/Etidronate Study Group. Am J Med. 1999 May. 106(5):513-20. [QxMD MEDLINE Link].

41. Roux C, Gennari C, Farrerons J, Devogelaer JP, Mulder H, Kruse HP, et al. Comparative prospective, double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget's disease of bone. Arthritis Rheum. 1995 Jun. 38(6):851-8. [QxMD MEDLINE Link].

42. Siris E, Weinstein RS, Altman R, Conte JM, Favus M, Lombardi A, et al. Comparative study of alendronate versus etidronate for the treatment of Paget's disease of bone. J Clin Endocrinol Metab. 1996 Mar. 81(3):961-7. [QxMD MEDLINE Link].

43. Al-Rashid M, Ramkumar DB, Raskin K, Schwab J, Hornicek FJ, Lozano-Calderón SA. Paget Disease of Bone. Orthop Clin North Am. 2015 Oct. 46 (4):577-85. [QxMD MEDLINE Link].

44. Walsh JP, Ward LC, Stewart GO, Will RK, Criddle RA, Prince RL. A randomized clinical trial comparing oral alendronate and intravenous pamidronate for the treatment of Paget's disease of bone. Bone. 2004 Apr. 34(4):747-54. [QxMD MEDLINE Link].

45. Reid IR, Miller P, Lyles K, Fraser W, Brown JP, Saidi Y, et al. Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease. N Engl J Med. 2005 Sep 1. 353(9):898-908. [QxMD MEDLINE Link].

46. Langston AL, Campbell MK, Fraser WD, MacLennan GS, Selby PL, Ralston SH. Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone. J Bone Miner Res. 2010 Jan. 25(1):20-31. [QxMD MEDLINE Link].

47. Tan A, Hudson J, Walker A, Fraser W, MacLennan G, Ralston S. Intensive bisphosphonate therapy increases the risk of fracture and requirement for orthopaedic surgery in Paget’s disease: the PRISM-EZ study. ECTS-IBMS Abstracts. 2015. [Full Text].

48. Cundy T, Maslowski K, Grey A, Reid IR. Durability of response to zoledronate treatment and competing mortality in Paget's disease of bone. J Bone Miner Res. 2016 Nov 3. [QxMD MEDLINE Link].

49. Merlotti D, Gennari L, Martini G, Valleggi F, De Paola V, Avanzati A, et al. Comparison of different intravenous bisphosphonate regimens for Paget's disease of bone. J Bone Miner Res. 2007 Oct. 22(10):1510-7. [QxMD MEDLINE Link].

50. Hosking D, Lyles K, Brown JP, Fraser WD, Miller P, Curiel MD. Long-term control of bone turnover in Paget's disease with zoledronic acid and risedronate. J Bone Miner Res. 2007 Jan. 22(1):142-8. [QxMD MEDLINE Link].

51. Reid IR, Lyles K, Su G, Brown JP, Walsh JP, del Pino-Montes J. A single infusion of zoledronic acid produces sustained remissions in Paget disease: data to 6.5 years. J Bone Miner Res. 2011 Sep. 26(9):2261-70. [QxMD MEDLINE Link].

52. Devogelaer JP, Geusens P, Daci E, Gielen E, Denhaerynck K, Macdonald K, et al. Remission over 3 years in patients with Paget disease of bone treated with a single intravenous infusion of 5 mg zoledronic acid. Calcif Tissue Int. 2014 Mar. 94(3):311-8. [QxMD MEDLINE Link].

53. Cronin O, Forsyth L, Goodman K, et al. Zoledronate in the prevention of Paget's (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget's disease of bone. BMJ Open. 2019 Sep 4. 9 (9):e030689. [QxMD MEDLINE Link]. [Full Text].

54. Parvizi J, Klein GR, Sim FH. Surgical management of Paget's disease of bone. J Bone Miner Res. 2006 Dec. 21 Suppl 2:P75-82. [QxMD MEDLINE Link].

55. Jorge-Mora A, Amhaz-Escanlar S, Lois-Iglesias A, Leborans-Eiris S, Pino-Minguez J. Surgical treatment in spine Paget's disease: a systematic review. Eur J Orthop Surg Traumatol. 2015 Jul 1. [QxMD MEDLINE Link].

56. [Guideline] Ralston SH, Corral-Gudino L, Cooper C, Francis RM, Fraser WD, Gennari L, et al. Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline. J Bone Miner Res. 2019 Apr. 34 (4):579-604. [QxMD MEDLINE Link]. [Full Text].

57. [Guideline] Singer FR, Bone HG 3rd, Hosking DJ, Lyles KW, Murad MH, Reid IR, et al. Paget's Disease of Bone: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2014 Dec. 99(12):4408-22. [QxMD MEDLINE Link].

58. Rasmusson L, Abtahi J. Bisphosphonate associated osteonecrosis of the jaw: an update on pathophysiology, risk factors, and treatment. Int J Dent. 2014. 2014:471035. [QxMD MEDLINE Link]. [Full Text].

Mujahed M Alikhan, MD Rheumatologist

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